Expression of human DNA mismatch‑repair protein, hMSH2, in patients with oral lichen planus

  • Authors:
    • Hao‑Bo Li
    • Ying‑Huai Zhang
    • Hui‑Zhen Chen
    • Yong Chen
  • View Affiliations

  • Published online on: November 6, 2014     https://doi.org/10.3892/etm.2014.2053
  • Pages: 203-206
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Abstract

hMSH2 is one of the human DNA mismatch repair genes that plays an important role in reducing mutations and maintaining genomic stability. The aim of the present study was to detect the expression and significance of hMSH2 protein in patients with oral lichen planus (OLP). The expression levels of hMSH2 in the OLP group (n=51) and control group with normal oral mucosa (NM; n=40) were detected using an immunohistochemical method and subsequently assessed. The positive rate of hMSH2 expression in the OLP group was 52.94%, while the rate was 80% in the control group, exhibiting a statistically significant difference (χ2=7.1993; P<0.05). However, the expression of hMSH2 in the OLP tissues was not shown to significantly correlate with the patient gender, age and type of OLP (P>0.05). In conclusion, the protein expression levels of hMSH2 in the OLP tissues were significantly reduced as compared with that in the NM tissues, indicating that hMSH2 plays a role in the development of OLP. Therefore, hMSH2 may be used as a biomarker for evaluating the cancer risk of patients with OLP.
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January-2015
Volume 9 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li HB, Zhang YH, Chen HZ and Chen Y: Expression of human DNA mismatch‑repair protein, hMSH2, in patients with oral lichen planus. Exp Ther Med 9: 203-206, 2015
APA
Li, H., Zhang, Y., Chen, H., & Chen, Y. (2015). Expression of human DNA mismatch‑repair protein, hMSH2, in patients with oral lichen planus. Experimental and Therapeutic Medicine, 9, 203-206. https://doi.org/10.3892/etm.2014.2053
MLA
Li, H., Zhang, Y., Chen, H., Chen, Y."Expression of human DNA mismatch‑repair protein, hMSH2, in patients with oral lichen planus". Experimental and Therapeutic Medicine 9.1 (2015): 203-206.
Chicago
Li, H., Zhang, Y., Chen, H., Chen, Y."Expression of human DNA mismatch‑repair protein, hMSH2, in patients with oral lichen planus". Experimental and Therapeutic Medicine 9, no. 1 (2015): 203-206. https://doi.org/10.3892/etm.2014.2053