Efficacy of intravesical Bacillus Calmette-Guérin therapy against tumor immune escape in an orthotopic model of bladder cancer

Huang,Peng; Ma,Chao; Xu,Peng; Guo,Kai; Xu,Abai; Liu,Chunxiao

doi:10.3892/etm.2014.2060

January-2015 Volume 9 Issue 1

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January-2015 Volume 9 Issue 1

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Article

Efficacy of intravesical Bacillus Calmette-Guérin therapy against tumor immune escape in an orthotopic model of bladder cancer

Authors:
- Peng Huang
- Chao Ma
- Peng Xu
- Kai Guo
- Abai Xu
- Chunxiao Liu
View Affiliations / Copyright

Affiliations: Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, P.R. China
Pages: 162-166
|
Published online on: November 11, 2014

https://doi.org/10.3892/etm.2014.2060
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Abstract

The aim of this study was to evaluate the antitumor immune response of the Bacillus Calmette‑Guérin (BCG) in an orthotopic bladder cancer model. The murine bladder cancer cell line MBT‑2 was transurethrally implanted in the bladder of syngeneic female C3H/He mice. The animals were randomly divided into three treatment groups: Phosphate‑buffered saline (PBS), low‑dose BCG and high‑dose BCG. The analyses of luciferin‑stained tumor images 28 days after each treatment showed significant tumor growth inhibition in the high‑dose group in comparison with that in the low‑dose‑ or PBS‑treated groups. In addition, the percentage of myeloid‑derived suppressor cells in the high‑dose group was significantly suppressed in comparison with that in the PBS and low‑dose agent treatment groups. These findings are notable in terms of the clinical evaluations of this therapy for patients with bladder cancer. The outcomes of this study also provide important implications regarding antitumor immune responses in human cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Efficacy of intravesical Bacillus Calmette-Guérin therapy against tumor immune escape in an orthotopic model of bladder cancer

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