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Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer

  • Authors:
    • Xianhua Xu
    • Ji Eun Kim
    • Ping-Li Sun
    • Seol Bong Yoo
    • Hyojin Kim
    • Yan Jin
    • Jin-Haeng Chung
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Jilin Cancer Hospital, Changchun, Jilin 130012, P.R. China, Department of Pathology, Seoul National University Boramae Hospital, Seoul 156‑707, Republic of Korea, Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 463‑707, Republic of Korea, Department of Pathology, Presbyterian Medical Center, Jeonju 560-750, Republic of Korea
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 311-318
    |
    Published online on: November 28, 2014
       https://doi.org/10.3892/etm.2014.2095
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Abstract

The protein β-catenin exhibits a dual function in cells, by acting as a major structural component of cell-cell adherens junctions and as a central signaling molecule in the Wnt signaling pathway. However, how the regulation of β-catenin expression during tumor metastasis in non-small cell lung cancer (NSCLC) varies according to histological type remains unclear. To investigate the regulatory mechanism of β-catenin on tumor metastasis, the present study compared the expression of Wnt1, β-catenin and E-cadherin in 41 primary NSCLC tumors and their corresponding metastatic lesions by immunohistochemistry. Altered expression of β-catenin was more frequent in the metastatic tumors (34/41, 82.9%) than in the corresponding primary tumors (24/41, 58.5%; P<0.05). There were 12 cases [nine of adenocarcinoma (ADC) and three of squamous cell carcinoma (SqCC)] that revealed discordant β-catenin expression between the primary tumors and the corresponding metastatic lesions. Of these, 11 cases (11/12, 91.7%; nine ADCs and two SqCCs) demonstrated acquired β-catenin alterations in the metastatic lesions. Subgroup analysis of these nine ADCs revealed that six cases (6/9, 66.7%) were accompanied by E-cadherin loss but no Wnt1 overexpression. Subgroup analysis of the three SqCCs revealed discordant β-catenin expression. Two cases (2/3, 66.7%) demonstrated acquired β-catenin expression during metastatic progression with Wnt1 overexpression but no change in E-cadherin expression. One case of SqCC revealed normal β-catenin expression in the metastasis although the expression was aberrant in the primary tumor. The results of the present study revealed that the changes in β-catenin expression occurred during tumor metastasis by different mechanisms, depending on histological type. The alterations in β-catenin expression may be regulated by a cadherin-catenin system in ADCs with reduced membranous expression of E-cadherin, but mediated by Wnt1 overexpression in SqCCs with cytoplasmic or nuclear transition types.
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Copy and paste a formatted citation
Spandidos Publications style
Xu X, Kim JE, Sun P, Yoo SB, Kim H, Jin Y and Chung J: Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer. Exp Ther Med 9: 311-318, 2015.
APA
Xu, X., Kim, J.E., Sun, P., Yoo, S.B., Kim, H., Jin, Y., & Chung, J. (2015). Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer. Experimental and Therapeutic Medicine, 9, 311-318. https://doi.org/10.3892/etm.2014.2095
MLA
Xu, X., Kim, J. E., Sun, P., Yoo, S. B., Kim, H., Jin, Y., Chung, J."Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer". Experimental and Therapeutic Medicine 9.2 (2015): 311-318.
Chicago
Xu, X., Kim, J. E., Sun, P., Yoo, S. B., Kim, H., Jin, Y., Chung, J."Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer". Experimental and Therapeutic Medicine 9, no. 2 (2015): 311-318. https://doi.org/10.3892/etm.2014.2095
Copy and paste a formatted citation
x
Spandidos Publications style
Xu X, Kim JE, Sun P, Yoo SB, Kim H, Jin Y and Chung J: Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer. Exp Ther Med 9: 311-318, 2015.
APA
Xu, X., Kim, J.E., Sun, P., Yoo, S.B., Kim, H., Jin, Y., & Chung, J. (2015). Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer. Experimental and Therapeutic Medicine, 9, 311-318. https://doi.org/10.3892/etm.2014.2095
MLA
Xu, X., Kim, J. E., Sun, P., Yoo, S. B., Kim, H., Jin, Y., Chung, J."Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer". Experimental and Therapeutic Medicine 9.2 (2015): 311-318.
Chicago
Xu, X., Kim, J. E., Sun, P., Yoo, S. B., Kim, H., Jin, Y., Chung, J."Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer". Experimental and Therapeutic Medicine 9, no. 2 (2015): 311-318. https://doi.org/10.3892/etm.2014.2095
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