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Article

Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection

  • Authors:
    • Yi Chen
    • Jiankai Fang
    • Xuzheng Chen
    • Chen Pan
    • Xiaolong Liu
    • Jingfeng Liu
  • View Affiliations / Copyright

    Affiliations: The Liver Center of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fuijan 350025, P.R. China, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fuijan 350108, P.R. China
  • Pages: 573-578
    |
    Published online on: December 3, 2014
       https://doi.org/10.3892/etm.2014.2104
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Abstract

The extent to which T‑cell‑mediated immunity is impaired in patients with hepatitis B virus (HBV) infection remains controversial. In addition, the role of T regulatory (Treg) and T helper 17 (Th17) cells and their associated cytokines in immunity is not clear. In the present study, peripheral blood samples were collected from 44 patients with chronic hepatitis B virus, 14 asymptomatic hepatitis B carriers, 19 patients with liver cirrhosis and 20 healthy individuals. Flow cytometry was used to detect the percentages of T cell subsets in the samples, including CD3+, CD4+ and CD8+ T cells, Treg cells and Th17 cells. A cytometric bead array was conducted to detect the levels of interleukin (IL)‑17, ‑6, ‑10 and ‑21, and transforming growth factor (TGF)‑β. The data revealed that Treg cell levels decreased, while Th17 cell levels increased in the peripheral blood of HBV patients. As the extent of inflammation and fibrosis in the hepatic tissue increased, the frequency of Treg and Th17 cells in the peripheral blood did not significantly differ. In addition, the levels of Th17 cells were found to positively correlate with TGF‑β and IL‑21 levels. Therefore, analyzing the balance between Treg/Th17 cells and their associated cytokines may be a useful indicator in the diagnosis of HBV.
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1 

Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association. The guideline of prevention and treatment for chronic hepatitis B (2010 version). Zhonghua Gan Zang Bing Za Zhi. 19:13–24. 2011.(In Chinese).

2 

Levrero M, Pollicino T, Petersen J, et al: Control of cccDNA function in hepatitis B virus infection. J Hepatol. 51:581–592. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Boni C, Fisicaro P, Valdatta C, et al: Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J Virol. 81:4215–4225. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Peng G, Li S, Wu W, et al: Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection. Immunology. 123:1357–1365. 2008. View Article : Google Scholar

5 

Yang G, Liu A, Xie Q, et al: Association of CD4+CD25+Foxp3+ regulatory T cells with chronic activity and viral clearance in patients with hepatitis B. Int Immunol. 19:133–140. 2007. View Article : Google Scholar

6 

Xu D, Fu J, Jin L, et al: Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol. 177:739–747. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Kondo Y, Kobayashi K, Ueno Y, et al: Mechanism of T cell hyporesponsiveness to HBcAg is associated with regulatory T cells in chronic hepatitis B. World J Gastroenterol. 12:4310–4317. 2006.PubMed/NCBI

8 

Xu D, Fu J, Jin L, Zhang H, et al: Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol. 177:739–747. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Stoop JN, van der Molen RG, Baan CC, et al: Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology. 41:771–778. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Curiel TJ: Tregs and rethinking cancer immunotherapy. J Clin Invest. 117:1167–1174. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Ruter J, Barnett BG, Kryczek I, et al: Altering regulatory T cell function in cancer immunotherapy: a novel means to boost the efficacy of cancer vaccines. Frontier Biosci (Landmark Ed). 14:1761–1770. 2009. View Article : Google Scholar

12 

Juang CM, Hung CF, Yeh JY, et al: Regulatory T cells: potential target in anticancer immunotherapy. Taiwan J Obstet Gynecol. 46:215–221. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Greten TF, Manns MP and Korangy F: Immunotherapy of hepatocellular carcinoma. J Hepatol. 45:868–878. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Romagnani S: T cell subpopulations. Chem Immunol Allergy. 100:155–164. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Hall BM, Verma ND, Tran GT and Hodginkson SJ: Distinct regulatory CD4+T cell subsets; differences between naïve and antigen specific T regulatory cells. Curr Opin Immunol. 23:641–647. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Bettelli E, Carrier Y, Gao W, et al: Reciprocal developmental pathways for generation of pathogenic effector Thl7 and regulatory T cells. Nature. 441:235–238. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Zhang Y, Ma D, Zhang Y, et al: The imbalance of Th17/Treg in patients with uterine cervical cancer. Clin Clim Acta. 412:894–900. 2011. View Article : Google Scholar

18 

Zhang B, Rong G, Wei H, et al: The prevalence of Th17 cells in patients with gastric cancer. Biochem Biophys Res Commun. 374:533–537. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Miyahara Y, Odunsi K, Chen W, et al: Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Proc Natl Acad Sci USA. 105:15505–15510. 2008. View Article : Google Scholar

20 

Le Gouvello S, Bastuji-Garin S, Aloulou N, et al: High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas. Gut. 57:772–779. 2008. View Article : Google Scholar

21 

Alatrakchi N and Koziel M: Regulatory T cells and viral liver disease. J Viral Hepat. 16:223–229. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Chen Z, Ding J, Pang N, et al: The Th17/Treg balance and the expression of related cytokines in Uygur cervical cancer patients. Diagn Pathol. 8:612013. View Article : Google Scholar : PubMed/NCBI

23 

Yu XL, Guo R, Ming D, et al: Ratios of regulatory T cells/T-helper 17 cells and tranforming growth factor-β1/interleukin-17 to be associated with the development of hepatitis B virus-associated liver cirrhosis. J Gastronenterol Hepatol. 29:1065–1072. 2014. View Article : Google Scholar

24 

Zhang GL, Xie DY, Lin BL, et al: Imbalance of interleukin-17-producing CD4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus-related acute-on-chronic liver failure. J Gastronenterol Hepatol. 28:513–521. 2013. View Article : Google Scholar

25 

Li Y, Tang L and Hou J: Role of interleukin-21 in HBV infection: friend or foe? Cell Mol Immunol. Nov 3–2014.(Epub ahead of print).

26 

Arababadi MK, Bidaki MZ and Kennedy D: IL-17A in hepatitis B infection: friend or foe? Arch Virol. 159:1883–1888. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Kimura A and Kishimoto T: IL-6: regulator of Treg/Th17 balance. J Immunol. 40:1830–1835. 2010.

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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Fang J, Chen X, Pan C, Liu X and Liu J: Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection. Exp Ther Med 9: 573-578, 2015.
APA
Chen, Y., Fang, J., Chen, X., Pan, C., Liu, X., & Liu, J. (2015). Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection. Experimental and Therapeutic Medicine, 9, 573-578. https://doi.org/10.3892/etm.2014.2104
MLA
Chen, Y., Fang, J., Chen, X., Pan, C., Liu, X., Liu, J."Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection". Experimental and Therapeutic Medicine 9.2 (2015): 573-578.
Chicago
Chen, Y., Fang, J., Chen, X., Pan, C., Liu, X., Liu, J."Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection". Experimental and Therapeutic Medicine 9, no. 2 (2015): 573-578. https://doi.org/10.3892/etm.2014.2104
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Fang J, Chen X, Pan C, Liu X and Liu J: Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection. Exp Ther Med 9: 573-578, 2015.
APA
Chen, Y., Fang, J., Chen, X., Pan, C., Liu, X., & Liu, J. (2015). Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection. Experimental and Therapeutic Medicine, 9, 573-578. https://doi.org/10.3892/etm.2014.2104
MLA
Chen, Y., Fang, J., Chen, X., Pan, C., Liu, X., Liu, J."Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection". Experimental and Therapeutic Medicine 9.2 (2015): 573-578.
Chicago
Chen, Y., Fang, J., Chen, X., Pan, C., Liu, X., Liu, J."Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection". Experimental and Therapeutic Medicine 9, no. 2 (2015): 573-578. https://doi.org/10.3892/etm.2014.2104
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