Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent

Zhong,Shao-Min; Sun,Nan; Liu,Hui-Xian; Niu,Yue-Qing; Wu,Yan

doi:10.3892/etm.2014.2118

February-2015 Volume 9 Issue 2

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February-2015 Volume 9 Issue 2

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Article Open Access

Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent

Authors:
- Shao-Min Zhong
- Nan Sun
- Hui-Xian Liu
- Yue-Qing Niu
- Yan Wu
View Affiliations / Copyright

Affiliations: Department of Dermatology, Peking University First Hospital, Beijing 100034, P.R. China

Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 341-344
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Published online on: December 8, 2014

https://doi.org/10.3892/etm.2014.2118
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Abstract

The aim of the present study was to evaluate the efficacy and safety of lignin peroxidase (LIP) as a skin‑lightening agent in patients with melasma. A self-controlled clinical study was performed in 31 women who had melasma on both sides of the face. This study involved 8 weeks of a full-face product treatment. The skin color was measured at days 0, 7, 28 and 56 using a chromameter on the forehead and cheeks. Standardized digital photographic images of each side of the face of all subjects were captured by a complexion analysis system. Clinical scores of the pigmentation were determined by two dermatologists. After using the LIP whitening lotion for 7 days, the luminance (L*) values of the melasma and the normal skin were significantly increased from baseline. The L* values continued to increase at days 28 and 56. The melasma area severity index (MASI) score was statistically decreased after 28 days of treatment. No treatment-related adverse events were observed. LIP whitening lotion was able to eliminate the skin pigmentation after 7 days of treatment, and provides a completely innovative approach to rapid skin lightening. The LIP whitening lotion exhibited good compatibility and was well tolerated.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Reduction of facial pigmentation of melasma by topical lignin peroxidase: A novel fast-acting skin-lightening agent

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