Correlation between nuclear factor κB activity and pulmonary artery pressure in a rat high pulmonary blood flow model

  • Authors:
    • Jie Yang
    • Xiao-Xiao Yu
    • Abduhaer Abulaiti
    • Jian-Chun Fei
  • View Affiliations

  • Published online on: December 8, 2014     https://doi.org/10.3892/etm.2014.2121
  • Pages: 543-546
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Abstract

The aim of the present study was to investigate the correlation between nuclear factor-κB (NF‑κB) activity and pulmonary artery pressure in the pulmonary artery endothelial cells of high pulmonary blood flow rat models. A total of 50 four‑week‑old male Wistar rats were randomly divided into four groups: Surgery shunt group (Tn, n=15); surgery + pyrollidine dithiocarbamate (PDTC) administration group (Ti, n=15); sham control group (Co, n=10) and negative control group (Cn, n=10). The 30 rats of the Ti and Tn groups underwent carotid artery‑external jugular vein anastomosis; the 15 rats in the Ti group were injected with PDTC intraperitoneally 1 h prior to surgery for a two‑week continuous infusion. After 12 weeks of feeding ad libitum, right ventricular systolic pressure and NF‑κB activity in the pulmonary artery endothelial cells of the rats were measured. The NF‑κB activity of the Tn group was significantly higher than that of the Cn group (P<0.01) and the NF‑κB activity of the Ti group was lower than that of the Cn group (P<0.01); however, no significant difference was observed between the Co and Cn groups. The increased activity of NF‑κB was an important factor in the pulmonary vasoconstriction and structural remodeling of rats with high pulmonary blood flow.
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February-2015
Volume 9 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yang J, Yu X, Abulaiti A and Fei J: Correlation between nuclear factor κB activity and pulmonary artery pressure in a rat high pulmonary blood flow model. Exp Ther Med 9: 543-546, 2015
APA
Yang, J., Yu, X., Abulaiti, A., & Fei, J. (2015). Correlation between nuclear factor κB activity and pulmonary artery pressure in a rat high pulmonary blood flow model. Experimental and Therapeutic Medicine, 9, 543-546. https://doi.org/10.3892/etm.2014.2121
MLA
Yang, J., Yu, X., Abulaiti, A., Fei, J."Correlation between nuclear factor κB activity and pulmonary artery pressure in a rat high pulmonary blood flow model". Experimental and Therapeutic Medicine 9.2 (2015): 543-546.
Chicago
Yang, J., Yu, X., Abulaiti, A., Fei, J."Correlation between nuclear factor κB activity and pulmonary artery pressure in a rat high pulmonary blood flow model". Experimental and Therapeutic Medicine 9, no. 2 (2015): 543-546. https://doi.org/10.3892/etm.2014.2121