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Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation

  • Authors:
    • Jing Wang
    • Gaoliang Yan
    • Yong Qiao
    • Dong Wang
    • Genshan Ma
    • Chengchun Tang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 361-366
    |
    Published online on: December 11, 2014
       https://doi.org/10.3892/etm.2014.2128
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Abstract

The aim of this study was to investigate the correlation between glycosylated hemoglobin (HbA1c) levels and the severity and long-term prognosis of coronary heart disease (CHD) with stent implantation. A total of 2,825 consecutive patients with stent implantation were stratified into three groups based on the levels of HbA1c: Low HbA1c group (group A, HbA1c ≤5.9% or 41 mmol/mol; n=1,035), moderate HbA1c group (group B, 5.9%< HbA1c <6.8% or 41< HbAlc <51 mmol/mol; n=1,025) and high HbA1c group (group C, HbA1c ≥6.8% or 51 mmol/mol; n=765). The impact of HbA1c on the Gensini score and the long-term prognosis of CHD with stent implantation were observed. After an average of 1 year of follow-up of the 2,825 patients in a hospital cohort, participants with low or high HbA1c had a higher risk of major adverse cardiac events (MACE) and target lesion revascularization (TLR) compared with participants with moderate HbA1c after adjusting for multiple potential confounders (hazard ratios for low HbAlc, 1.505 and 1.478, respectively, and for high HbAlc, 1.626 and 1.522, respectively). Analysis of HbA1c as a continuous variable showed that each 1% increase of HbA1c was significantly associated with decreased risks of MACE and TLR of 53.5 and 54.2%, respectively, in those with a low HbA1c level and with increased risks of MACE and TLR of 9.5 and 9.2%, respectively, in those with a moderate or high HbA1c level, suggesting a U-shaped association between HbA1c and the risk of MACE and TLR. In conclusion, HbA1c levels, either as a continuous variable or a categorical variable, have a U-shaped correlation with MACE and TLR in CHD patients with stent implantation, even after adjustment for multiple confounders.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Yan G, Qiao Y, Wang D, Ma G and Tang C: Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation. Exp Ther Med 9: 361-366, 2015.
APA
Wang, J., Yan, G., Qiao, Y., Wang, D., Ma, G., & Tang, C. (2015). Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation. Experimental and Therapeutic Medicine, 9, 361-366. https://doi.org/10.3892/etm.2014.2128
MLA
Wang, J., Yan, G., Qiao, Y., Wang, D., Ma, G., Tang, C."Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation". Experimental and Therapeutic Medicine 9.2 (2015): 361-366.
Chicago
Wang, J., Yan, G., Qiao, Y., Wang, D., Ma, G., Tang, C."Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation". Experimental and Therapeutic Medicine 9, no. 2 (2015): 361-366. https://doi.org/10.3892/etm.2014.2128
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Yan G, Qiao Y, Wang D, Ma G and Tang C: Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation. Exp Ther Med 9: 361-366, 2015.
APA
Wang, J., Yan, G., Qiao, Y., Wang, D., Ma, G., & Tang, C. (2015). Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation. Experimental and Therapeutic Medicine, 9, 361-366. https://doi.org/10.3892/etm.2014.2128
MLA
Wang, J., Yan, G., Qiao, Y., Wang, D., Ma, G., Tang, C."Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation". Experimental and Therapeutic Medicine 9.2 (2015): 361-366.
Chicago
Wang, J., Yan, G., Qiao, Y., Wang, D., Ma, G., Tang, C."Different levels of glycosylated hemoglobin influence severity and long-term prognosis of coronary heart disease patients with stent implantation". Experimental and Therapeutic Medicine 9, no. 2 (2015): 361-366. https://doi.org/10.3892/etm.2014.2128
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