Therapeutic potential of hepatocyte growth factor against cerebral ischemia (Review)

Nakamura T, Nawa K, Ichihara A, Kaise N and Nishino T: Purification and subunit structure of hepatocyte growth factor from rat platelets. FEBS Lett. 224:311–316. 1987. View Article : Google Scholar : PubMed/NCBI

Nakamura T, Nawa K and Ichihara A: Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun. 122:1450–1459. 1984. View Article : Google Scholar : PubMed/NCBI

Nakamura T, Nishizawa T, Hagiya M, et al: Molecular cloning and expression of human hepatocyte growth factor. Nature. 342:440–443. 1989. View Article : Google Scholar : PubMed/NCBI

Ohmichi H, Matsumoto K and Nakamura T: In vivo mitogenic action of HGF on lung epithelial cells: pulmotrophic role in lung regeneration. Am J Physiol. 270:L1031–L1039. 1996.PubMed/NCBI

Hamanoue M, Takemoto N, Matsumoto K, Nakamura T, Nakajima K and Kohsaka S: Neurotrophic effect of hepatocyte growth factor on central nervous system neurons in vitro. J Neurosci Res. 43:554–564. 1996. View Article : Google Scholar : PubMed/NCBI

Achim C, Katyal S, Wiley C, et al: Expression of HGF and cMet in the developing and adult brain. Brain Res Dev Brain Res. 102:299–303. 1997. View Article : Google Scholar : PubMed/NCBI

Sun W, Funakoshi H and Nakamura T: Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS. J Neurosci. 22:6537–6548. 2002.PubMed/NCBI

Zarnegar R and Michalopoulos G: The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis. J Cell Biol. 129:1177–1180. 1995. View Article : Google Scholar : PubMed/NCBI

Matsumoto K and Nakamura T: Emerging multipotent aspects of hepatocyte growth factor. J Biochem. 119:591–600. 1996. View Article : Google Scholar : PubMed/NCBI

Miyazawa T, Matsumoto K, Ohmichi H, Katoh H, Yamashima T and Nakamura T: Protection of hippocampal neurons from ischemia-induced delayed neuronal death by hepatocyte growth factor: a novel neurotrophic factor. J Cereb Blood Flow Metab. 18:345–348. 1998. View Article : Google Scholar : PubMed/NCBI

Tsuzuki N, Miyazawa T, Matsumoto K, Nakamura T and Shima K: Hepatocyte growth factor reduces the infarct volume after transient focal cerebral ischemia in rats. Neurol Res. 23:417–424. 2001. View Article : Google Scholar : PubMed/NCBI

Shimamura M, Sato N, Oshima K, et al: Novel therapeutic strategy to treat brain ischemia: overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model. Circulation. 109:424–431. 2004. View Article : Google Scholar : PubMed/NCBI

Nakamura T, Nawa K and Ichihara A: Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun. 122:1450–1459. 1984. View Article : Google Scholar : PubMed/NCBI

Abounader R and Laterra J: Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis. Neuro Oncol. 7:436–451. 2005. View Article : Google Scholar : PubMed/NCBI

Matsumoto K and Nakamura T: Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions. Crit Rev Oncog. 3:27–54. 1992.PubMed/NCBI

Ma PC, Maulik G, Christensen J and Salgia R: c-Met: structure, functions and potential for therapeutic inhibition. Cancer Metastasis Rev. 22:309–325. 2003. View Article : Google Scholar : PubMed/NCBI

Organ SL and Tsao MS: An overview of the c-MET signaling pathway. Ther Adv Med Oncol. 3(Suppl 1): S7–S19. 2011. View Article : Google Scholar : PubMed/NCBI

Lawrence RE and Salgia R: MET molecular mechanisms and therapies in lung cancer. Cell Adh Migr. 4:146–152. 2010. View Article : Google Scholar : PubMed/NCBI

Trusolino L, Bertotti A and Comoglio PM: MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol. 11:834–848. 2010. View Article : Google Scholar : PubMed/NCBI

Okano J, Shiota G, Matsumoto K, et al: Hepatocyte growth factor exerts a proliferative effect on oval cells through the PI3K/AKT signaling pathway. Biochem Biophys Res Commun. 309:298–304. 2003. View Article : Google Scholar : PubMed/NCBI

Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Woude GFV and Testa JR: Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci USA. 98:247–252. 2001. View Article : Google Scholar : PubMed/NCBI

Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med. 285:1182–1186. 1971. View Article : Google Scholar : PubMed/NCBI

Folkman J and Shing Y: Angiogenesis. J Biol Chem. 267:10931–10934. 1992.PubMed/NCBI

Henry TD: Therapeutic angiogenesis. BMJ. 318:1536–1539. 1999. View Article : Google Scholar : PubMed/NCBI

Krupinski J, Kaluza J, Kumar P, Kumar S and Wang JM: Role of angiogenesis in patients with cerebral ischemic stroke. Stroke. 25:1794–1798. 1994. View Article : Google Scholar : PubMed/NCBI

Shimotake J, Derugin N, Wendland M, Vexler ZS and Ferriero DM: Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke. Stroke. 41:343–349. 2010. View Article : Google Scholar : PubMed/NCBI

Yang JP, Liu HJ and Liu XF: VEGF promotes angiogenesis and functional recovery in stroke rats. J Invest Surg. 23:149–155. 2010. View Article : Google Scholar : PubMed/NCBI

Ferrara N: Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int. 56:794–814. 1999. View Article : Google Scholar : PubMed/NCBI

Yano A, Shingo T, Takeuchi A, et al: Encapsulated vascular endothelial growth factor-secreting cell grafts have neuroprotective and angiogenic effects on focal cerebral ischemia. J Neurosurg. 103:104–114. 2005. View Article : Google Scholar : PubMed/NCBI

Bellomo M, Adamo EB, Deodato B, et al: Enhancement of expression of vascular endothelial growth factor after adeno-associated virus gene transfer is associated with improvement of brain ischemia injury in the gerbil. Pharmacol Res. 48:309–317. 2003. View Article : Google Scholar : PubMed/NCBI

Harrigan MR, Ennis SR, Masada T and Keep RF: Intraventricular infusion of vascular endothelial growth factor promotes cerebral angiogenesis with minimal brain edema. Neurosurgery. 50:589–598. 2002.PubMed/NCBI

Shen F, Su H, Fan Y, et al: Adeno-associated viral vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice. Stroke. 37:2601–2606. 2006. View Article : Google Scholar : PubMed/NCBI

Rosen EM, Laterra J, Joseph A, et al: Scatter factor expression and regulation in human glial tumors. Int J Cancer. 67:248–255. 1996. View Article : Google Scholar : PubMed/NCBI

Shang J, Deguchi K, Ohta Y, et al: Strong neurogenesis, angiogenesis, synaptogenesis, and antifibrosis of hepatocyte growth factor in rats brain after transient middle cerebral artery occlusion. J Neurosci Res. 89:86–95. 2011. View Article : Google Scholar

Date I, Takagi N, Takagi K, et al: Hepatocyte growth factor attenuates cerebral ischemia-induced learning dysfunction. Biochem Biophys Res Commun. 319:1152–1158. 2004. View Article : Google Scholar : PubMed/NCBI

Date I, Takagi N, Takagi K, et al: Hepatocyte growth factor attenuates cerebral ischemia-induced increase in permeability of the blood-brain barrier and decreases in expression of tight junctional proteins in cerebral vessels. Neurosci Lett. 407:141–145. 2006. View Article : Google Scholar : PubMed/NCBI

Morishita R, Aoki M, Hashiya N, et al: Therapeutic angiogenesis using hepatocyte growth factor (HGF). Curr Gene Ther. 4:199–206. 2004. View Article : Google Scholar : PubMed/NCBI

Aoki M, Morishita R, Taniyama Y, et al: Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: up-regulation of essential transcription factor for angiogenesis, ets. Gene Ther. 7:417–427. 2000. View Article : Google Scholar : PubMed/NCBI

Nakagami H, Morishita R, Yamamoto K, et al: Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells. Hypertension. 37:581–586. 2001. View Article : Google Scholar : PubMed/NCBI

Dong G, Chen Z, Li ZY, Yeh NT, Bancroft CC and Van Waes C: Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. Cancer Res. 61:5911–5918. 2001.PubMed/NCBI

Ma P, Tretiakova M, Nallasura V, Jagadeeswaran R, Husain A and Salgia R: Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion. Br J Cancer. 97:368–377. 2007. View Article : Google Scholar : PubMed/NCBI

Yamamoto K, Morishita R, Hayashi S, et al: Contribution of Bcl-2, but not Bcl-xL and Bax, to antiapoptotic actions of hepatocyte growth factor in hypoxia-conditioned human endothelial cells. Hypertension. 37:1341–1348. 2001. View Article : Google Scholar : PubMed/NCBI

Wang X, Zhou Y, Kim HP, et al: Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells. J Biol Chem. 279:5237–5243. 2004. View Article : Google Scholar

Davis GE and Senger DR: Endothelial extracellular matrix biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ Res. 97:1093–1107. 2005. View Article : Google Scholar : PubMed/NCBI

Chang C and Werb Z: The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol. 11:S37–S43. 2001. View Article : Google Scholar : PubMed/NCBI

Wang H and Keiser JA: Hepatocyte growth factor enhances MMP activity in human endothelial cells. Biochem Biophys Res Commun. 272:900–905. 2000. View Article : Google Scholar : PubMed/NCBI

Bussolino F, Di Renzo M, Ziche M, et al: Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol. 119:629–641. 1992. View Article : Google Scholar : PubMed/NCBI

Xin X, Yang S, Ingle G, et al: Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. Am J Pathol. 158:1111–1120. 2001. View Article : Google Scholar : PubMed/NCBI

Tomita N, Morishita R, Taniyama Y, et al: Angiogenic property of hepatocyte growth factor is dependent on upregulation of essential transcription factor for angiogenesis, ets-1. Circulation. 107:1411–1417. 2003. View Article : Google Scholar : PubMed/NCBI

Zhang YW, Su Y, Volpert OV and Woude GF: Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation. Proc Natl Acad Sci USA. 100:12718–12723. 2003. View Article : Google Scholar : PubMed/NCBI

Scarpino S, Di Napoli A, Taraboletti G, Cancrini A and Ruco LP: Hepatocyte growth factor (HGF) downregulates thrombospondin 1 (TSP-1) expression in thyroid papillary carcinoma cells. J Pathol. 205:50–56. 2005. View Article : Google Scholar

Birukova AA, Alekseeva E, Mikaelyan A and Birukov KG: HGF attenuates thrombin-induced endothelial permeability by Tiam1-mediated activation of the Rac pathway and by Tiam1/Rac-dependent inhibition of the Rho pathway. FASEB J. 21:2776–2786. 2007. View Article : Google Scholar : PubMed/NCBI

Kaga T, Kawano H, Sakaguchi M, Nakazawa T, Taniyama Y and Morishita R: Hepatocyte growth factor stimulated angiogenesis without inflammation: Differential actions between hepatocyte growth factor, vascular endothelial growth factor and basic fibroblast growth factor. Vascul Pharmacol. 57:3–9. 2012. View Article : Google Scholar : PubMed/NCBI

Yao X, Miao W, Li M, et al: Protective effect of albumin on VEGF and brain edema in acute ischemia in rats. Neurosci Lett. 472:179–183. 2010. View Article : Google Scholar : PubMed/NCBI

Wang Y, Kilic E, Kilic, et al: VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena. Brain. 128:52–63. 2005. View Article : Google Scholar

Zhang ZG, Zhang L, Jiang Q, et al: VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest. 106:829–872. 2000. View Article : Google Scholar : PubMed/NCBI

Szydlowska K and Tymianski M: Calcium, ischemia and excitotoxicity. Cell Calcium. 47:122–129. 2010. View Article : Google Scholar : PubMed/NCBI

Hayashi K, Morishita R, Nakagami H, et al: Gene therapy for preventing neuronal death using hepatocyte growth factor: in vivo gene transfer of HGF to subarachnoid space prevents delayed neuronal death in gerbil hippocampal CA1 neurons. Gene Ther. 8:1167–1173. 2001. View Article : Google Scholar : PubMed/NCBI

Niimura M, Takagi N, Takagi K, et al: Prevention of apoptosis-inducing factor translocation is a possible mechanism for protective effects of hepatocyte growth factor against neuronal cell death in the hippocampus after transient forebrain ischemia. J Cereb Blood Flow Metab. 26:1354–1365. 2006. View Article : Google Scholar : PubMed/NCBI

Qiu J, Cafferty WB, McMahon SB and Thompson SW: Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation. J Neurosci. 25:1645–1653. 2005. View Article : Google Scholar : PubMed/NCBI

Dziennis S and Alkayed NJ: Role of signal transducer and activator of transcription 3 in neuronal survival and regeneration. Rev Neurosci. 19:341–362. 2008. View Article : Google Scholar

He F, Wu LX, Shu KX, et al: HGF protects cultured cortical neurons against hypoxia/reoxygenation induced cell injury via ERK1/2 and PI-3K/Akt pathways. Colloids Surf B Biointerfaces. 61:290–297. 2008. View Article : Google Scholar

van Velthoven CT, Kavelaars A, van Bel F and Heijnen CJ: Regeneration of the ischemic brain by engineered stem cells: fuelling endogenous repair processes. Brain Res Rev. 61:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

Dharmasaroja P: Bone marrow-derived mesenchymal stem cells for the treatment of ischemic stroke. J Clin Neurosci. 16:12–20. 2009. View Article : Google Scholar

Lee HJ, Kim KS, Kim EJ, et al: Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model. Stem Cell. 25:1204–1212. 2007. View Article : Google Scholar

Tang Y, Yasuhara T, Hara K, et al: Transplantation of bone marrow-derived stem cells: a promising therapy for stroke. Cell Transplant. 16:159–169. 2007.PubMed/NCBI

Kokuzawa J, Yoshimura S, Kitajima H, et al: Hepatocyte growth factor promotes proliferation and neuronal differentiation of neural stem cells from mouse embryos. Mol Cell Neurosci. 24:190–197. 2003. View Article : Google Scholar : PubMed/NCBI

Forte G, Minieri M, Cossa P, et al: Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells. 24:23–33. 2006. View Article : Google Scholar

Nicoleau C, Benzakour O, Agasse F, et al: Endogenous hepatocyte growth factor is a niche signal for subventricular zone neural stem cell amplification and self-renewal. Stem Cells. 27:408–419. 2009. View Article : Google Scholar

Zheng B, Wang C, He L, et al: Neural differentiation of mesenchymal stem cells influences chemotactic responses to HGF. J Cell Physiol. 228:149–162. 2013. View Article : Google Scholar

Vogel S, Peters C, Etminan N, et al: Migration of mesenchymal stem cells towards glioblastoma cells depends on hepatocyte-growth factor and is enhanced by aminolaevulinic acid-mediated photodynamic treatment. Biochem Biophys Res Commun. 431:428–432. 2013. View Article : Google Scholar : PubMed/NCBI

Kendall SE, Najbauer J, Johnston HF, et al: Neural stem cell targeting of glioma is dependent on phosphoinositide 3-kinase signaling. Stem Cells. 26:1575–1586. 2008. View Article : Google Scholar : PubMed/NCBI

Zhang H, Muramatsu T, Murase A, Yuasa S, Uchimura K and Kadomatsu K: N-Acetylglucosamine 6-O-sulfotransferase-1 is required for brain keratan sulfate biosynthesis and glial scar formation after brain injury. Glycobiology. 16:702–710. 2006. View Article : Google Scholar : PubMed/NCBI

Sofroniew MV: Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 32:638–647. 2009. View Article : Google Scholar : PubMed/NCBI

Silver J and Miller J: Regeneration beyond the glial scar. Nat Rev Neurosci. 5:146–156. 2004. View Article : Google Scholar : PubMed/NCBI

Fitch MT and Silver J: CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure. Exp Neurol. 209:294–301. 2008. View Article : Google Scholar

Wanner IB, Deik A, Torres M, et al: A new in vitro model of the glial scar inhibits axon growth. GLIA. 56:1691–1709. 2008. View Article : Google Scholar : PubMed/NCBI

Voskuhl RR, Peterson RS, Song B, et al: Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. J Neurosci. 29:11511–11522. 2009. View Article : Google Scholar : PubMed/NCBI

Rolls A, Shechter R and Schwartz M: The bright side of the glial scar in CNS repair. Nat Rev Neurosci. 10:235–241. 2009. View Article : Google Scholar : PubMed/NCBI

Ha X, Li Y, Lao M, Yuan B and Wu C: Effect of human hepatocyte growth factor on promoting wound healing and preventing scar formation by adenovirus-mediated gene transfer. Chin Med J (Engl). 116:1029–1033. 2003.

Liu C, Wu Z, Shu C, et al: Experimental investigation of HGF inhibiting glial scar in vitro. Cell Mol Neurobiol. 31:259–268. 2011. View Article : Google Scholar

McKeon RJ, Jurynec MJ and Buck CR: The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar. J Neurosci. 19:10778–10788. 1999.PubMed/NCBI

Yin J, Sakamoto K, Zhang H, et al: Transforming growth factor-beta1 upregulates keratan sulfate and chondroitin sulfate biosynthesis in microglias after brain injury. Brain Res. 1263:10–22. 2009. View Article : Google Scholar : PubMed/NCBI

Schachtrup C, Ryu JK, Helmrick MJ, et al: Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-β after vascular damage. J Neurosci. 30:5843–5854. 2010. View Article : Google Scholar : PubMed/NCBI

Jeong SR, Kwon MJ, Lee HG, et al: Hepatocyte growth factor reduces astrocytic scar formation and promotes axonal growth beyond glial scars after spinal cord injury. Exp Neurol. 233:312–322. 2011. View Article : Google Scholar : PubMed/NCBI

Seth A and Watson DK: ETS transcription factors and their emerging roles in human cancer. Eur J Cancer. 41:2462–2478. 2005. View Article : Google Scholar : PubMed/NCBI

Powell RJ, Simons M, Mendelsohn FO, et al: Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia. Circulation. 118:58–65. 2008. View Article : Google Scholar : PubMed/NCBI

Shimamura M, Sato N, Yoshimura S, Kaneda Y and Morishita R: HVJ-based non-viral gene transfer method: successful gene therapy using HGF and VEGF genes in experimental ischemia. Front Biosci. 11:753–759. 2006. View Article : Google Scholar

Bosch A, McCray PB Jr, Walters KS, et al: Effects of keratinocyte and hepatocyte growth factor in vivo: implications for retrovirus-mediated gene transfer to liver. Hum Gene Ther. 9:1747–1754. 1998. View Article : Google Scholar : PubMed/NCBI

Nolta JA and Kohn DB: Comparison of the effects of growth factors on retroviral vector-mediated gene transfer and the proliferative status of human hematopoietic progenitor cells. Hum Gene Ther. 1:257–268. 1990. View Article : Google Scholar : PubMed/NCBI

Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH and Blaese RM: In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science. 256:1550–1552. 1992. View Article : Google Scholar : PubMed/NCBI

Thomas CE, Ehrhardt A and Kay MA: Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet. 4:346–358. 2003. View Article : Google Scholar : PubMed/NCBI

Zhao MZ, Nonoguchi N, Ikeda N, et al: Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector. J Cereb Blood Flow Metab. 26:1176–1188. 2006.PubMed/NCBI

Li JF, Yin HL, Shuboy A, et al: Differentiation of hUC-MSC into dopaminergic-like cells after transduction with hepatocyte growth factor. Mol Cell Biochem. 381:183–190. 2013. View Article : Google Scholar : PubMed/NCBI

Kurozumi K, Nakamura K, Tamiya T, et al: BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model. Mol Ther. 9:189–197. 2004. View Article : Google Scholar : PubMed/NCBI

Neuss S, Becher E, Wöltje M, et al: Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing. Stem Cells. 22:405–414. 2004. View Article : Google Scholar : PubMed/NCBI

Ishikawa H, Jo JI and Tabata Y: Liver anti-fibrosis therapy with mesenchymal stem cells secreting hepatocyte growth factor. J Biomater Sci Polym Ed. 23:2259–2272. 2012.

Gao CF and Woude GFV: HGF/SF-Met signaling in tumor progression. Cell Res. 15:49–51. 2005. View Article : Google Scholar : PubMed/NCBI

Zhang YW, Wang LM, Jove R and Vande WG: Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis. Oncogene. 21:217–226. 2002. View Article : Google Scholar : PubMed/NCBI

Qian F, Engst S, Yamaguchi K, et al: Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res. 69:8009–8016. 2009. View Article : Google Scholar : PubMed/NCBI

Peruzzi B and Bottaro DP: Targeting the c-Met signaling pathway in cancer. Clin Cancer Res. 12:3657–3660. 2006. View Article : Google Scholar : PubMed/NCBI