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Article

Effect of Zhuyun recipe on endometrial pinopode expression in mice with embryonic implantation dysfunction and ovulation stimulation

  • Authors:
    • Nan Yu
    • Wenjie Yan
    • Yaqin Wang
    • Tailang Yin
    • Yue Guo
    • Jing Yang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
  • Pages: 488-492
    |
    Published online on: December 16, 2014
       https://doi.org/10.3892/etm.2014.2138
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Abstract

Zhuyun recipe (ZYR) is a traditional Chinese medicine that has been widely used as an infertility treatment for a number of years. Although the therapeutic effects are desirable and satisfactory, the therapeutic mechanism of ZYR remains poorly understood. In the present study, pinopodes were investigated as an important morphological marker of endometrial receptivity, in order to further investigate the therapeutic mechanism of ZYR. The expression of pinopodes during the implantation window was observed using scanning electron microscopy in mice with induced ovarian stimulation (OS) and embryo implantation dysfunction (EID). A marked decrease in the number of fully developed pinopodes was observed on the endometrial surface in the OS and EID model mice, which was in accordance with the decreased pregnancy rate and number of embryonic implantation sites when compared with the control. Following treatment with ZYR, the spatial and temporal expression of pinopodes in the OS and EID mice was found to be similar to the control mice. In conclusion, ZYR was demonstrated to improve endometrial receptivity in OS and EID mice through significant improvements in the spatial and temporal expression of pinopodes.
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1 

Boomsma CM, Kavelaars A, Eijkemans MJ, et al: Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF. Hum Reprod. 24:1427–1435. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Santos MA, Kuijk EW and Macklon NS: The impact of ovarian stimulation for IVF on the developing embryo. Reproduction. 139:23–34. 2010. View Article : Google Scholar

3 

Cavagna M and Mantese JC: Biomarkers of endometrial receptivity - a review. Placenta 24 (Suppl B): S39–S47, 2003 Psychoyos A: Hormonal control of ovoimplantation. Vitam Horm. 31:201–256. 1973.

4 

Psychoyos A: Hormonal control of uterine receptivity for nidation. J Reprod Fertil Suppl. 17–28. 1976.PubMed/NCBI

5 

Acosta AA, Elberger L, Borghi M, et al: Endometrial dating and determination of the window of implantation in healthy fertile women. Fertil Steril. 73:788–798. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Nikas G: Endometrial receptivity: changes in cell-surface morphology. Semin Reprod Med. 18:229–235. 2000. View Article : Google Scholar

7 

Yu N, Yang J and Yin T: Extracts from a traditional Chinese herbal remedy (Zhuyun recipe) improve endometrial receptivity in mice with embryonic implantation dysfunction and ovulation stimulation. J Ethnopharmacol. 137:389–395. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Jiang M, Liu YF, Lv YY and Huang L: The effect mechanism of Traditional Chinese medicine to improve the receptivity of endometrium. Zhong Yi Za Zhi. 54:1064–1066. 2013.(In Chinese).

9 

Liu YJ, Huang GY, Lu F, et al: Establishment of mice model with embryo implantation dysfunction. Zhong Guo Yao Li Xue Tong Bao. 19:1315–1318. 2003.(In Chinese).

10 

Nikas G: Pinopodes as markers of endometrial receptivity in clinical practice. Hum Reprod. 14(Suppl 2): S99–S106. 1999. View Article : Google Scholar

11 

Salehnia M: Different pattern of pinopodes expression in stimulated mouse endometrium. Exp Anim. 54:349–352. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Huang DM, Huang GY and Lu FE: Effect of Bushenyiqihexue recipe on the expression of endometrial pinopodes in blastocyst implantation dysfunctional mice. Zhonghua Fu Chan Ke Za Zhi. 39:230–233. 2004.(In Chinese). PubMed/NCBI

13 

Pantos K, Nikas G, Makrakis E, et al: Clinical value of endometrial pinopodes detection in artificial donation cycles. Reprod Biomed Online. 9:86–90. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Nikas G, Drakakis P, Loutradis D, et al: Uterine pinopodes as markers of the ‘nidation window’ in cycling women receiving exogenous oestradiol and progesterone. Hum Reprod. 10:1208–1213. 1995.PubMed/NCBI

15 

Nikas G, Develioglu OH, Toner JP and Jones HW Jr: Endometrial pinopodes indicate a shift in the window of receptivity in IVF cycles. Hum Reprod. 14:787–792. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Lopata A, Bentin-Ley U and Enders A: ‘Pinopodes’ and implantation. Rev Endocr Metab Disord. 3:77–86. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Huang DM, Nardo LG, Huang GY, et al: Effect of a single dose of mifepristone on expression of pinopodes in endometrial surface of mice. Acta Pharmacol Sin. 26:212–219. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Busso CE, Melo MA, Fernandez M, et al: Implantation in IVF. Int Surg. 91(5 Suppl): S63–S76. 2006.

19 

Diedrich K, Fauser BC, Devroey P and Griesinger G; Evian Annual Reproduction (EVAR) Workshop Group. The role of the endometrium and embryo in human implantation. Hum Reprod Update. 13:365–377. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Stavreus-Evers A, Nikas G, Sahlin L, et al: Formation of pinopodes in human endometrium is associated with the concentrations of progesterone and progesterone receptors. Fertil Steril. 76:782–791. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Martel D, Monier MN, Roche D and Psychoyos A: Hormonal dependence of pinopode formation at the uterine luminal surface. Hum Reprod. 6:597–603. 1991.PubMed/NCBI

22 

Kodaman PH and Taylor HS: Hormonal regulation of implantation. Obstet Gynecol Clin North Am. 31:745–766. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Li F, Li E, Lu Z, et al: Effects of icarrin on secretive function of cultured granulosa and adrenal cortical cells of rats. Zhongguo Zhong Yao Za Zhi. 22:499–500. 1997.(In Chinese).

24 

Qin D, Zuo B and Zuo Y: Effects of flavonoids of Semen Cuscutae on reproductive function of animals. Zhong Yao Xin Yao Yu Lin Chuang Yao Li. 11:349–351. 2000.(In Chinese).

25 

Chen XY, Cheng MJ and Ye ZQ: Study on invigorating Yang effect of time-selecting administration of Morinda officinalis How. Lin Chuang He Li Yong Yao. 2:31–32. 2009.(In Chinese).

26 

Hunag WG, Zeng QZ, Pan ZX and Tang JK: Study on the main pharmacodynamics and acute toxicity of eucommia leaves electuary. Gui Zhou Yi Yao. 24:325–326. 2000.(In Chinese).

27 

Cakmak H and Taylor HS: Implantation failure: molecular mechanisms and clinical treatment. Hum Reprod Update. 17:242–253. 2011. View Article : Google Scholar :

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Copy and paste a formatted citation
Spandidos Publications style
Yu N, Yan W, Wang Y, Yin T, Guo Y and Yang J: Effect of Zhuyun recipe on endometrial pinopode expression in mice with embryonic implantation dysfunction and ovulation stimulation. Exp Ther Med 9: 488-492, 2015.
APA
Yu, N., Yan, W., Wang, Y., Yin, T., Guo, Y., & Yang, J. (2015). Effect of Zhuyun recipe on endometrial pinopode expression in mice with embryonic implantation dysfunction and ovulation stimulation. Experimental and Therapeutic Medicine, 9, 488-492. https://doi.org/10.3892/etm.2014.2138
MLA
Yu, N., Yan, W., Wang, Y., Yin, T., Guo, Y., Yang, J."Effect of Zhuyun recipe on endometrial pinopode expression in mice with embryonic implantation dysfunction and ovulation stimulation". Experimental and Therapeutic Medicine 9.2 (2015): 488-492.
Chicago
Yu, N., Yan, W., Wang, Y., Yin, T., Guo, Y., Yang, J."Effect of Zhuyun recipe on endometrial pinopode expression in mice with embryonic implantation dysfunction and ovulation stimulation". Experimental and Therapeutic Medicine 9, no. 2 (2015): 488-492. https://doi.org/10.3892/etm.2014.2138
Copy and paste a formatted citation
x
Spandidos Publications style
Yu N, Yan W, Wang Y, Yin T, Guo Y and Yang J: Effect of Zhuyun recipe on endometrial pinopode expression in mice with embryonic implantation dysfunction and ovulation stimulation. Exp Ther Med 9: 488-492, 2015.
APA
Yu, N., Yan, W., Wang, Y., Yin, T., Guo, Y., & Yang, J. (2015). Effect of Zhuyun recipe on endometrial pinopode expression in mice with embryonic implantation dysfunction and ovulation stimulation. Experimental and Therapeutic Medicine, 9, 488-492. https://doi.org/10.3892/etm.2014.2138
MLA
Yu, N., Yan, W., Wang, Y., Yin, T., Guo, Y., Yang, J."Effect of Zhuyun recipe on endometrial pinopode expression in mice with embryonic implantation dysfunction and ovulation stimulation". Experimental and Therapeutic Medicine 9.2 (2015): 488-492.
Chicago
Yu, N., Yan, W., Wang, Y., Yin, T., Guo, Y., Yang, J."Effect of Zhuyun recipe on endometrial pinopode expression in mice with embryonic implantation dysfunction and ovulation stimulation". Experimental and Therapeutic Medicine 9, no. 2 (2015): 488-492. https://doi.org/10.3892/etm.2014.2138
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