search button

Effect of valsartan on atrial fibrillation recurrence following pulmonary vein isolation in patients

  • Authors:
    • Yingkai Cui
    • Changsheng Ma
    • Deyong Long
    • Liping Wang
    • Xuebin Cao
    • Ghang Zhang

  • View Affiliations

  • Published online on: December 16, 2014     https://doi.org/10.3892/etm.2014.2143
  • Pages: 631-635
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Pulmonary venous isolation has emerged as an effective therapy for atrial fibrillation (AF); however, AF recurrence is common. The aim of the present study was to investigate the effect of angiotensin receptor blockers (ARBs) on the recurrence rate of AF following ablation therapy. In total, 120 patients, who were scheduled for ablation, were randomly selected. The patients were randomly divided into three groups, which received treatment with a placebo (n=40), 80 mg valsartan daily (n=40) or with 160 mg valsartan daily (n=40). The demographic characteristics, comorbidities, AF type and information regarding treatment with ARBs were recorded and analyzed. Following a mean follow‑up period of 13.8±8.6 months, 66.7% of patients were found to be free of AF. Kaplan‑Meier analysis of the time until the first recurrence during the follow‑up period revealed that patients treated with 160 mg/day valsartan presented a higher probability of remaining free of AF (88%, vs. 47% for the control and 65% for the 80 mg/day valsartan groups). In addition, multivariate analysis demonstrated that treatment with ARB was associated with lower AF recurrence rates (hazard ratio, 0.46; 95% confidence interval, 0.20‑0.93] P=0.01). In conclusion, treatment with 160 mg/day valsartan markedly reduced the risk of recurrence of AF in a dose‑dependent manner in AF patients following ablation.
View Figures
View References

Related Articles

Journal Cover

February-2015
Volume 9 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.7
  • Ranked Medicine Research and Experimental
    (total number of cites)
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Cui Y, Ma C, Long D, Wang L, Cao X and Zhang G: Effect of valsartan on atrial fibrillation recurrence following pulmonary vein isolation in patients. Exp Ther Med 9: 631-635, 2015
APA
Cui, Y., Ma, C., Long, D., Wang, L., Cao, X., & Zhang, G. (2015). Effect of valsartan on atrial fibrillation recurrence following pulmonary vein isolation in patients. Experimental and Therapeutic Medicine, 9, 631-635. https://doi.org/10.3892/etm.2014.2143
MLA
Cui, Y., Ma, C., Long, D., Wang, L., Cao, X., Zhang, G."Effect of valsartan on atrial fibrillation recurrence following pulmonary vein isolation in patients". Experimental and Therapeutic Medicine 9.2 (2015): 631-635.
Chicago
Cui, Y., Ma, C., Long, D., Wang, L., Cao, X., Zhang, G."Effect of valsartan on atrial fibrillation recurrence following pulmonary vein isolation in patients". Experimental and Therapeutic Medicine 9, no. 2 (2015): 631-635. https://doi.org/10.3892/etm.2014.2143