Treatment of chest wall tuberculosis with transdermal ultrasound-mediated drug delivery

Han,Yi; Zhao,Qiuyue; Yu,Daping; Liu,Zhidong

doi:10.3892/etm.2015.2219

April-2015 Volume 9 Issue 4

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April-2015 Volume 9 Issue 4

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Article

Treatment of chest wall tuberculosis with transdermal ultrasound-mediated drug delivery

Authors:
- Yi Han
- Qiuyue Zhao
- Daping Yu
- Zhidong Liu
View Affiliations / Copyright

Affiliations: Second Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing 101149, P.R. China
Pages: 1433-1437
|
Published online on: January 27, 2015

https://doi.org/10.3892/etm.2015.2219
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Abstract

Chest wall tuberculosis (TB) is an endemic disease with a large number of variants. The condition affects numerous parts of the body and can penetrate the skin to form chronic open ulcers. Current treatment methods include oral anti‑TB drugs and surgery. However, conventional drug treatments are not effective due to the difficulty in achieving an effective local concentration, and certain patients are unable to tolerate surgery. The recurrence rate for chest wall TB is high following surgery, and may result in the prolonged healing of wounds in certain patients, as well as chronic sinusitis and fistula formation. To identify a safe, simple, less invasive and more clinically effective treatment method, the present study investigated transdermal ultrasound‑mediated anti‑TB drug delivery. A total of 186 patients were selected and randomly divided into transdermal ultrasound, surgery and oral anti‑TB drug only groups. Rifampicin was the drug delivered by transdermal ultrasound. The cure and efficiency rates were shown to be 87.10 and 93.55%, respectively, in the ultrasound treatment group. No statistically significant difference was observed in the cure rates between the transdermal ultrasound and surgery groups; however, a statistically significant difference was identified in the cure rates between the transdermal ultrasound and oral anti‑TB drug only groups. Therefore, transdermal ultrasound technology was shown to deliver anti‑TB drugs quickly and directly, which resulted in a high local concentration of the drug, overcoming the problem of obtaining an effective local drug concentration. The observations demonstrated that transdermal ultrasound‑mediated drug delivery is an effective method by which to control TB, particularly when compared with traditional oral anti‑TB therapy and surgery.

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1	Gupta R, Espinal MA and Raviglione MC: Tuberculosis as a major global health problem in the 21st century: a WHO perspective. Semin Respir Crit Care Med. 25:245–253. 2004. View Article : Google Scholar
2	Golden MP and Vikram HR: Extrapulmonary Tuberculosis: an overview. Am Fam Physician. 72:1761–1768. 2005.PubMed/NCBI
3	Gaude GS and Reyas A: Tuberculosis of the chest wall without pulmonary involvement. Lung India. 25:135–137. 2008. View Article : Google Scholar : PubMed/NCBI
4	Grosset J: Mycobacterium tuberculosis in the extracellular compartment: an underestimated adversary. Antimicrob Agents Chemother. 47:833–836. 2003. View Article : Google Scholar : PubMed/NCBI
5	Mitragotri S, Edwards DA, Blankschtein D and Langer R: A mechanistic study of ultrasonically-enhanced transdermal drug delivery. J Pharm Sci. 84:697–706. 1995. View Article : Google Scholar : PubMed/NCBI
6	Packer JL, Krall B and Torabinejad M: The effect of sonophoresis on topical anesthesia: a pilot project. Anesth Prog. 60:37–41. 2013. View Article : Google Scholar : PubMed/NCBI
7	Kuzucu A, Soysal O and Günen H: The role of surgery in chest wall tuberculosis. Interact Cardiovasc Thorac Surg. 3:99–103. 2004. View Article : Google Scholar
8	Kurth R and Haas WH: Epidemiology, diagnostic possibilities, and treatment of tuberculosis. Ann Rheum Dis. 61(Suppl 2): ii59–ii61. 2002. View Article : Google Scholar : PubMed/NCBI
9	Sia IG and Wieland ML: Current concepts in the management of tuberculosis. Mayo Clin Proc. 86:348–361. 2011. View Article : Google Scholar : PubMed/NCBI
10	Sharma SK and Mohan A: Extrapulmonary tuberculosis. Indian J Med Res. 120:316–353. 2004.PubMed/NCBI
11	Smith I: Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence. ClinMicrobiol Rev. 16:463–496. 2003.
12	Gözübüyük A, Ozpolat B, Gürkök S, et al: Surgical management of chest wall TB. J Cutan Med Surg. 13:33–39. 2009.
13	Keum DY, Kim JB and Park CK: Surgical treatment of a tuberculous abscess of the chest wall. Korean J Thorac Cardiovasc Surg. 45:177–182. 2012. View Article : Google Scholar : PubMed/NCBI
14	Deng B, Tan QY, Wang RW, et al: Surgical strategy for tubercular abscess in the chest wall: experience of 120 cases. Eur J Cardiothorac Surg. 41:1349–1352. 2012. View Article : Google Scholar : PubMed/NCBI
15	Tanaka S, Aoki M, Nakanishi T, et al: Retrospective case series analysing the clinical data and treatment options of patients with a tubercular abscess of the chest wall. Interact Cardiovasc Thorac Surg. 14:249–252. 2012. View Article : Google Scholar :
16	Zhang N, Xu QZ, Fu XN and Sun W: Use of a pedicled omental flap in the treatment of chest wall TB. Ann Thorac Surg. 93:1010–1012. 2012. View Article : Google Scholar : PubMed/NCBI
17	Lim SY, Pyon JK, Mun GH, Bang SI and Oh KS: Reconstructive surgical treatment of tuberculosis abscess in the chest wall. Ann Plast Surg. 64:302–306. 2010. View Article : Google Scholar : PubMed/NCBI
18	Lavon I, Grossman N and Kost J: The nature of ultrasound-SLS synergism during enhanced transdermal transport. J Control Release. 107:484–494. 2005. View Article : Google Scholar : PubMed/NCBI
19	Simonetti LD, Gelfuso GM, Barbosa JC and Lopez RF: Assessment of the percutaneous penetration of cisplatin: the effect of monoolein and the drug skin penetration. Eur J Pharm Biopharm. 73:90–94. 2009. View Article : Google Scholar : PubMed/NCBI
20	Dubey V, Mishra D and Jain NK: Melatonin loaded ethanolic liposomes: physicochemical characterization and enhanced transdermal delivery. Eur J Pharm Biopharm. 67:398–405. 2007. View Article : Google Scholar : PubMed/NCBI
21	Funk RH, Monesees T and Ozkucur N: Electromagnetic effects - From cell biology to medicine. Prog Histochem Cytochem. 43:177–264. 2009. View Article : Google Scholar : PubMed/NCBI
22	Schoellhammer CM, Polat BE, Mendenhall J, et al: Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound. J Control Release. 163:154–160. 2012. View Article : Google Scholar : PubMed/NCBI
23	Polat BE, Figueroa PL, Blankschtein D and Langer R: Transport pathways and enhancement mechanisms within localized and non-localized transport regions in skin treated with low-frequency sonophoresis and sodium lauryl sulfate. J Pharm Sci. 100:512–529. 2011. View Article : Google Scholar :

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Treatment of chest wall tuberculosis with transdermal ultrasound-mediated drug delivery

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