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Article

Preconditioning with cobalt chloride modifies pain perception in mice

  • Authors:
    • Teodora Alexa
    • Andrei Luca
    • Andrei Dondas
    • Catalina Roxana Bohotin
  • View Affiliations / Copyright

    Affiliations: Center for the Study and Therapy of Pain, ‘Grigore T. Popa’ University of Medicine and Pharmacy, Iași, Moldavia 70115, Romania
  • Pages: 1465-1469
    |
    Published online on: January 29, 2015
       https://doi.org/10.3892/etm.2015.2235
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Abstract

Cobalt chloride (CoCl2) modifies mitochondrial permeability and has a hypoxic‑mimetic effect; thus, the compound induces tolerance to ischemia and increases resistance to a number of injury types. The aim of the present study was to investigate the effects of CoCl2 hypoxic preconditioning for three weeks on thermonociception, somatic and visceral inflammatory pain, locomotor activity and coordination in mice. A significant pronociceptive effect was observed in the hot plate and tail flick tests after one and two weeks of CoCl2 administration, respectively (P<0.001). Thermal hyperalgesia (Plantar test) was present in the first week, but recovered by the end of the experiment. Contrary to the hyperalgesic effect on thermonociception, CoCl2 hypoxic preconditioning decreased the time spent grooming the affected area in the second phase of the formalin test on the orofacial and paw models. The first phase of formalin‑induced pain and the writhing test were not affected by CoCl2 preconditioning. Thus, the present study demonstrated that CoCl2 preconditioning has a dual effect on pain, and these effects should be taken into account along with the better‑known neuro‑, cardio‑ and renoprotective effects of CoCl2.
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1 

Sullivan J, Parker M and Carson SB: Tissue cobalt content in ‘beer drinkers’ myocardiopathy’. J Lab Clin Med. 71:893–911. 1968.PubMed/NCBI

2 

Battaglia V, Compagnone A, Bandino A, et al: Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeability transition and intrinsic apoptosis in hepatocyte primary cultures. Int J Biochem Cell Biol. 41:586–594. 2009. View Article : Google Scholar

3 

Barceloux DG: Cobalt. J Toxicol Clin Toxicol. 37:201–206. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Gerber U and Gähwiler BH: Cobalt blocks postsynaptic responses induced by neurotransmitters in the hippocampus in vitro. Neurosci Lett. 134:53–56. 1991. View Article : Google Scholar : PubMed/NCBI

5 

Akbar M, Brewer JM and Grant MH: Effect of chromium and cobalt ions on primary human lymphocytes in vitro. J Immunotoxicol. 8:140–149. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Czarnota M, Whitman D and Berman R: Activity and passive-avoidance learning in cobalt-injected rats. Int J Neurosci. 93:29–33. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Chen SL, Yang CT, Yang ZL, et al: Hydrogen sulphide protects H9c2 cells against chemical hypoxia-induced injury. Clin Exp Pharmacol Physiol. 37:316–321. 2010. View Article : Google Scholar

8 

Lee M, Lapham A, Brimmell M, et al: Inhibition of proteasomal degradation of Mcl-1 by cobalt chloride suppresses cobalt chloride-induced apoptosis in HCT116 colorectal cancer cells. Apoptosis. 13:972–982. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Saxena S, Shukla D and Bansal A: Augmentation of aerobic respiration and mitochondrial biogenesis in skeletal muscle by hypoxia preconditioning with cobalt chloride. Toxicol Appl Pharmacol. 264:324–334. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Kalpana S, Dhananjay S, Anju B, et al: Cobalt chloride attenuates hypobaric hypoxia induced vascular leakage in rat brain: molecular mechanisms of action of cobalt chloride. Toxicol Appl Pharmacol. 231:354–363. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Singh M, Shukla D, Thomas P, et al: Hypoxic preconditioning facilitates acclimatization to hypobaric hypoxia in rat heart. J Pharm Pharmacol. 62:1729–1739. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Matsumoto M, Makino Y, Tanaka T, et al: Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats. J Am Soc Nephrol. 14:1825–1832. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Shrivastava K, Shukla D, Bansal A, et al: Neuroprotective effect of cobalt chloride on hypobaric hypoxia-induced oxidative stress. Neurochem Int. 52:368–375. 2008. View Article : Google Scholar

14 

Salvemini D, Little JW, Doyle T and Neumann WL: Roles of reactive oxygen and nitrogen species in pain. Free Radic Biol Med. 51:951–966. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes. OJ L. 276:33–79. 2010.

16 

1991 Guidelines for the Use of Animals in Research. Animal Behav. 41:183–186. 1991. View Article : Google Scholar

17 

Woolfe G and MacDonald AD: The evaluation of the analgesic action of pethidine hydrochloride (Demerol). J Pharmacol Exp Ther. 80:300–307. 1944.

18 

D’Amour FE and Smith DL: A method for determining loss of pain sensation. J Pharmacol Exp Ther. 72:74–79. 1941.

19 

Hargreaves K, Dubner R, Brown F, et al: A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 32:77–88. 1988. View Article : Google Scholar : PubMed/NCBI

20 

Tegeder I, Del Turco D, Schmidtko A, et al: Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. Proc Natl Acad Sci USA. 101:3253–3257. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Koster R, Anderson M and Beer EJ: Acetic acid for analgesic screening. Federation Proceeds. 18:412–416. 1959.

22 

Hunskaar S, Fasmer OB and Hole K: Formalin test in mice, a useful technique for evaluating mild analgesics. J Neurosci Methods. 14:69–76. 1985. View Article : Google Scholar : PubMed/NCBI

23 

Luccarini P, Childeric A, Gaydier AM, et al: The orofacial formalin test in the mouse: a behavioral model for studying physiology and modulation of trigeminal nociception. J Pain. 7:908–914. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Shukla D, Saxena S, Purushothaman J, et al: Hypoxic preconditioning with cobalt ameliorates hypobaric hypoxia induced pulmonary edema in rat. Eur J Pharmacol. 656:101–109. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Gebhart GF and Ossipov MH: Characterization of inhibition of the spinal nociceptive tail-flick reflex in the rat from the medullary lateral reticular nucleus. J Neurosci. 6:701–713. 1986.PubMed/NCBI

26 

Kubo K, Nishikawa K, Ishizeki J, et al: Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase 65. J Pharmacol Exp Ther. 331:162–169. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Haghighi SS, Oro JJ, Gibbs SR and McFadden M: Effect of graded hypoxia on cortical and spinal somatosensory evoked potentials. Surg Neurol. 37:350–355. 1992. View Article : Google Scholar : PubMed/NCBI

28 

Bian D, Ossipov MH, Zhong C, et al: Tactile allodynia, but not thermal hyperalgesia, of the hindlimbs is blocked by spinal transection in rats with nerve injury. Neurosci Lett. 241:79–82. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Vogel C, Mössner R, Gerlach M, et al: Absence of thermal hyperalgesia in serotonin transporter-deficient mice. J Neurosci. 23:708–715. 2003.PubMed/NCBI

30 

Huang C, Hu ZP, Long H, et al: Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain. Brain Res Bull. 63:99–103. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Curto-Reyes V, Juárez L, García-Pérez E, et al: Local loperamide inhibits thermal hyperalgesia but not mechanical allodynia induced by intratibial inoculation of melanoma cells in mice. Cell Mol Neurobiol. 28:981–990. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Apostoli P, Catalani S, Zaghini A, et al: High doses of cobalt induce optic and auditory neuropathy. Exp Toxicol Pathol. 65:719–727. 2013. View Article : Google Scholar

33 

Catalani S, Rizzetti MC, Padovani A and Apostoli P: Neurotoxicity of cobalt. Hum Exp Toxicol. 31:421–437. 2012. View Article : Google Scholar

34 

Wang P, Zhang H, Chu F, et al: Synthesis and protective effect of new ligustrazine-benzoic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells. Molecules. 18:13027–13042. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Björklund O, Shang M, Tonazzini I, et al: Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage. Eur J Pharmacol. 596:6–13. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Burnstock G: Purinergic signalling: pathophysiology and therapeutic potential. Keio J Med. 62:63–73. 2013. View Article : Google Scholar : PubMed/NCBI

37 

De Felice M, Sanoja R, Wang R, et al: Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. Pain. 152:2701–2709. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Fields HL, Malick A and Burstein R: Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla. J Neurophysiol. 74:1742–1759. 1995.PubMed/NCBI

39 

Maione S, Piscitelli F, Gatta L, et al: Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action. Br J Pharmacol. 162:584–596. 2011. View Article : Google Scholar :

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Copy and paste a formatted citation
Spandidos Publications style
Alexa T, Luca A, Dondas A and Bohotin CR: Preconditioning with cobalt chloride modifies pain perception in mice. Exp Ther Med 9: 1465-1469, 2015.
APA
Alexa, T., Luca, A., Dondas, A., & Bohotin, C.R. (2015). Preconditioning with cobalt chloride modifies pain perception in mice. Experimental and Therapeutic Medicine, 9, 1465-1469. https://doi.org/10.3892/etm.2015.2235
MLA
Alexa, T., Luca, A., Dondas, A., Bohotin, C. R."Preconditioning with cobalt chloride modifies pain perception in mice". Experimental and Therapeutic Medicine 9.4 (2015): 1465-1469.
Chicago
Alexa, T., Luca, A., Dondas, A., Bohotin, C. R."Preconditioning with cobalt chloride modifies pain perception in mice". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1465-1469. https://doi.org/10.3892/etm.2015.2235
Copy and paste a formatted citation
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Spandidos Publications style
Alexa T, Luca A, Dondas A and Bohotin CR: Preconditioning with cobalt chloride modifies pain perception in mice. Exp Ther Med 9: 1465-1469, 2015.
APA
Alexa, T., Luca, A., Dondas, A., & Bohotin, C.R. (2015). Preconditioning with cobalt chloride modifies pain perception in mice. Experimental and Therapeutic Medicine, 9, 1465-1469. https://doi.org/10.3892/etm.2015.2235
MLA
Alexa, T., Luca, A., Dondas, A., Bohotin, C. R."Preconditioning with cobalt chloride modifies pain perception in mice". Experimental and Therapeutic Medicine 9.4 (2015): 1465-1469.
Chicago
Alexa, T., Luca, A., Dondas, A., Bohotin, C. R."Preconditioning with cobalt chloride modifies pain perception in mice". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1465-1469. https://doi.org/10.3892/etm.2015.2235
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