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Article

Curcumin improves the paclitaxel‑induced apoptosis of HPV‑positive human cervical cancer cells via the NF‑κB‑p53‑caspase‑3 pathway

Retraction in: /10.3892/etm.2025.12902
  • Authors:
    • Yu-Ping Dang
    • Xiao-Ying Yuan
    • Rong Tian
    • Dong-Guang Li
    • Wei Liu
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Air Force General Hospital of People's Liberation Army, Beijing 100142, P.R. China
  • Pages: 1470-1476
    |
    Published online on: January 29, 2015
       https://doi.org/10.3892/etm.2015.2240
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Abstract

Paclitaxel, isolated from Taxus brevifolia, is considered to be an efficacious agent against a wide spectrum of human cancers, including human cervical cancer. However, dose‑limiting toxicity and high cost limit its clinical application. Curcumin, a nontoxic food additive, has been reported to improve paclitaxel chemotherapy in mouse models of cervical cancer. However, the underlying mechanisms remain unclear. In this study, two human cervical cancer cell lines, CaSki [human papilloma virus (HPV)16‑positive] and HeLa (HPV18‑positive), were selected in which to investigate the effect of curcumin on the anticancer action of paclitaxel and further clarify the mechanisms. Flow cytometry and MTT analysis demonstrated that curcumin significantly promoted paclitaxel‑induced apoptosis and cytotoxicity in the two cervical cell lines compared with that observed with paclitaxel alone (P<0.05). Reverse transcription‑polymerase chain reaction indicated that the decline of HPV E6 and E7 gene expression induced by paclitaxel was also assisted by curcumin. The expression levels of p53 protein and cleaved caspase‑3 were increased significantly in the curcumin plus paclitaxel‑treated HeLa and CaSki cells compared with those in the cells treated with paclitaxel alone (P<0.01). Significant reductions in the levels of phosphorylation of IκBα and the p65‑NF‑κB subunit in CaSki cells treated with curcumin and paclitaxel were observed compared with those in cells treated with paclitaxel alone (P<0.05). This suggests that the combined effect of curcumin and paclitaxel was associated with the NF‑κB‑p53‑caspase‑3 pathway. In conclusion, curcumin has the ability to improve the paclitaxel‑induced apoptosis of HPV‑positive human cervical cancer cell lines via the NF‑κB‑p53‑caspase‑3 pathway. Curcumin in combination with paclitaxel may provide a superior therapeutic effect on human cervical cancer.
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1 

Bian ML, Cheng JY, Ma L, Cong X, Liu J, Chen Y and Chen X: Evaluation of the detection of 14 high-risk human papillomaviruses with HPV 16 and HPV 18 genotyping for cervical cancer screening. Exp Ther Med. 6:1332–1336. 2013.PubMed/NCBI

2 

Chao A, Lin CT and Lai CH: Updates in systemic treatment for metastatic cervical cancer. Curr Treat Option Oncol. 15:1–13. 2014. View Article : Google Scholar

3 

Lu X, Wu L, Liu Z, Xie L and Wang S: Peripheral blood mononuclear cells inhibit proliferation and promote apoptosis of HeLa cells following stimulation with Bacillus Calmette-Guerin. Exp Ther Med. 5:561–566. 2013.PubMed/NCBI

4 

Distefano M, Fagotti A, Ferrandina G, Fanfani F, Smaniotto D, D’Agostino G, Morganti A and Scambia G: Preoperative chemoradiotherapy in locally advanced cervical cancer: long-term outcome and complications. Gynecol Oncol. 99(3 Suppl 1): S166–S170. 2005. View Article : Google Scholar

5 

Kjellström J, Oredsson SM and Wennerberg J: Increased toxicity of a trinuclear Pt-compound in a human squamous carcinoma cell line by polyamine depletion. Cancer Cell Int. 12:202012. View Article : Google Scholar : PubMed/NCBI

6 

Kanamori Y, Kigawa J, Minagawa Y, Irie T, Itamochi H, Cheng X, Okada M and Terakawa N: Clinical responses and platinum concentrations in tumors after intra-arterial and intravenous administration of cisplatin in the same patients with cervical cancer. Gynecol Obstet Invest. 44:57–60. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Sun XY, Zheng YP, Lin DH, Zhang H, Zhao F and Yuan CS: Potential anti-cancer activities of furanodiene, a sesquiterpene from Curcuma wenyujin. Am J Chin Med. 37:589–596. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Grundmann O, Fillinger JL, Victory KR, Burd R and Limesand KH: Restoration of radiation therapy-induced salivary gland dysfunction in mice by post therapy IGF-1 administration. BMC cancer. 10:4172010. View Article : Google Scholar : PubMed/NCBI

9 

Termrungruanglert W, Kudelka AP, Piamsomboon S, Edwards CL, Verschraegen CF, Loyer E and Kavanagh JJ: Remission of recurrent cervical cancer with paclitaxel and carboplatin: a case report and review of literature. Eur J Gynaecol Oncol. 17:493–496. 1996.PubMed/NCBI

10 

Zanetta G, Fei F and Mangioni C: Chemotherapy with paclitaxel, ifosfamide, and cisplatin for the treatment of squamous cell cervical cancer: the experience of Monza. Semin Oncol. 27:23–27. 2000.PubMed/NCBI

11 

Braicu EI, Fotopoulou C, Chekerov R, Richter R, Blohmer J, Kummel S, Stamatian F, Yalcinkaya I, Mentze M, Lichtenegger W and Sehouli J: Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy. Cytokine. 61:755–758. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Sreekanth CN, Bava SV, Sreekumar E and Anto RJ: Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer. Oncogene. 30:3139–3152. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Lee KH, Yim EK, Kim SJ, Namkoong SE, Um SJ and Park JS: Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 98:45–53. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Park DC, Yeo SG, Shin EY, Mok SC and Kim DH: Clusterin confers paclitaxel resistance in cervical cancer. Gynecol Oncol. 103:996–1000. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Kuo DY, Blank SV, Christos PJ, Kim M, Caputo TA, Pothuri B, Hershman D, Goldman N, Ivy PS, Runowicz CD, Muggia F, Goldberg GL and Einstein MH: Paclitaxel plus oxaliplatin for recurrent or metastatic cervical cancer: a New York Cancer Consortium Study. Gynecol Oncol. 116:442–446. 2010. View Article : Google Scholar :

16 

Saito I, Kitagawa R, Fukuda H, Shibata T, Katsumata N, Konishi I, Yoshikawa H and Kamura T: A phase III trial of paclitaxel plus carboplatin versus paclitaxel plus cisplatin in stage IVB, persistent or recurrent cervical cancer: Gynecologic cancer study group/Japan clinical oncology group study (JCOG0505). Jpn J Clin Oncol. 40:90–93. 2010. View Article : Google Scholar

17 

Kosmas C, Mylonakis N, Tsakonas G, Vorgias G, Karvounis N, Tsavaris N, Daladimos T, Kalinoglou N, Malamos N, Akrivos T and Karabelis A: Evaluation of the paclitaxel-ifosfamide-cisplatin (TIP) combination in relapsed and/or metastatic cervical cancer. Br J Cancer. 101:1059–1065. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Moore KN, Herzog TJ, Lewin S, Giuntoli RL, Armstrong DK, Rocconi RP, Spannuth WA and Gold MA: A comparison of cisplatin/paclitaxel and carboplatin/paclitaxel in stage IVB, recurrent or persistent cervical cancer. Gynecol Oncol. 105:299–303. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Karaman M, Firinci F, Cilaker S, Uysal P, Tugyan K, Yilmaz O, Uzuner N and Karaman O: Anti-inflammatory effects of curcumin in a murine model of chronic asthma. Allergol Immunopathol (Madr). 40:210–214. 2012. View Article : Google Scholar

20 

Jacob JN, Badyal DK, Bala S and Toloue M: Evaluation of the in vivo anti-inflammatory and analgesic and in vitro anti-cancer activities of curcumin and its derivatives. Nat Prod Commun. 8:359–362. 2013.PubMed/NCBI

21 

Sreenivasan S and Krishnakumar S: Synthestic effect of curcumin in combination with Anticancer agents in human retinoblastoma cancer cells lines. Curr Eye Res. 11:1–13. 2014. View Article : Google Scholar

22 

Basnet P and Skalko-Basnet N: Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules. 16:4567–4598. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Bava SV, Sreekanth CN, Thulasidasan AK, Anto NP, Cheriyan VT, Puliyappadamba VT, Menon SG, Ravichandran SD and Anto RJ: Akt is upstream and MAPKs are downstream of NF-kappaB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism. Int J Biochem Cell Biol. 43:331–341. 2011. View Article : Google Scholar

24 

Hossain M, Banik NL and Ray SK: Synergistic anti-cancer mechanisms of curcumin and paclitaxel for growth inhibition of human brain tumor stem cells and LN18 and U138MG cells. Neurochem Int. 61:1102–1113. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Bava SV, Puliappadamba VT, Deepti A, Nair A, Karunagaran D and Anto RJ: Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization. J Biol Chem. 280:6301–6308. 2005. View Article : Google Scholar

26 

Boztas AO, Karakuzu O, Galante G, Ugur Z, Kocabas F, Altuntas CZ and Yazaydin AO: Synergistic interaction of paclitaxel and curcumin with cyclodextrin polymer complexation in human cancer cells. Mol Pharm. 10:2676–2683. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Brem GJ, Mylonas I and Brüning A: Eeyarestatin causes cervical cancer cell sensitization to bortezomib treatment by augmenting ER stress and CHOP expression. Gynecol Oncol. 128:383–390. 2013. View Article : Google Scholar

28 

Skiles ML, Sahai S and Blanchette JO: Tracking hypoxic signaling within encapsulated cell aggregates. J Vis Exp. 58:35212011.

29 

Li GL, Jiang W, Xia Q, Chen SH, Ge XR, Gui SQ and Xu CJ: HPV E6 down-regulation and apoptosis induction of human cervical cancer cells by a novel lipid-soluble extract (PE) from Pinellia pedatisecta Schott in vitro. J Ethnopharmacol. 132:56–64. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Jackson R, Togtema M and Zehbe I: Subcellular localization and quantitation of the human papillomavirus type 16 E6 oncoprotein through immunocytochemistry detection. Virology. 435:425–432. 2013. View Article : Google Scholar

31 

Arroyo M, Bagchi S and Raychaudhuri P: Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex. Mol Cell Biol. 13:6537–6546. 1993.PubMed/NCBI

32 

Goel A and Aggarwal BB: Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer. 62:919–930. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Tan S, de Vries EG, van der Zee AG and de Jong S: Anticancer drugs aimed at E6 and E7 activity in HPV-positive cervical cancer. Curr Cancer Drug Targets. 12:170–184. 2012. View Article : Google Scholar

34 

Kim MS, Bak Y, Park YS, Lee DH, Kim JH, Kang JW, Song HH, Oh SR and Yoon DY: Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV-16 cervical cancer cells. Cell Biol Toxicol. 29:259–272. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Zhou J, Li B, Peng C, Wang F, Fu Z, Zhou C, Hong D, Ye F, Lü W and Xie X: Inhibition of cervical cancer cell growth in vitro and in vivo by lentiviral-vector mediated shRNA targeting the common promoter of HPV16 E6 and E7 oncogenes. Antiviral Res. 98:305–313. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Teissier S, Ben Khalifa Y, Mori M, Pautier P, Desaintes C and Thierry F: A new E6/P63 pathway, together with a strong E7/E2F mitotic pathway, modulates the transcriptome in cervical cancer cells. J Virol. 81:9368–9376. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Chiu TH, Lan KY, Yang MD, Lin JJ, Hsia TC, Wu CT, Yang JS, Chueh FS and Chung JG: Diallyl sulfide promotes cell-cycle arrest through the p53 expression and triggers induction of apoptosis via caspase- and mitochondria-dependent signaling pathways in human cervical cancer Ca Ski cells. Nutr Cancer. 65:505–514. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Zhou X, Gu Y and Zhang SL: Association between p53 codon 72 polymorphism and cervical cancer risk among Asians: a HuGE review and meta-analysis. Asian Pac J Cancer Prev. 13:4909–4914. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Vidya Priyadarsini R, Senthil Murugan R, Maitreyi S, Ramalingam K, Karunagaran D and Nagini S: The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. Eur J Pharmacol. 649:84–91. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Habbous S, Pang V, Eng L, Xu W, Kurtz G, Liu FF, Mackay H, Amir E and Liu G: p53 Arg72Pro polymorphism, HPV status and initiation, progression, and development of cervical cancer: a systematic review and meta-analysis. Clin Cancer Res. 18:6407–6415. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Shi M, Du L, Liu D, Qian L, Hu M, Yu M, Yang Z, Zhao M, Chen C, Guo L, Wang L, Song L, Ma Y and Guo N: Glucocorticoid regulation of a novel HPV-E6-p53-miR-145 pathway modulates invasion and therapy resistance of cervical cancer cells. J Pathol. 228:148–157. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Ristriani T, Fournane S, Orfanoudakis G, Travé G and Masson M: A single-codon mutation converts HPV16 E6 oncoprotein into a potential tumor suppressor, which induces p53-dependent senescence of HPV-positive HeLa cervical cancer cells. Oncogene. 28:762–772. 2009. View Article : Google Scholar

43 

Fiedler M, Müller-Holzner E, Viertler HP, Widschwendter A, Laich A, Pfister G, Spoden GA, Jansen-Dürr P and Zwerschke W: High level HPV-16 E7 oncoprotein expression correlates with reduced pRb-levels in cervical biopsies. FASEB J. 18:1120–1122. 2004.PubMed/NCBI

44 

Loignon M and Drobetsky EA: The initiation of UV-induced G(1) arrest in human cells is independent of the p53/p21/pRb pathway but can be attenuated through expression of the HPV E7 oncoprotein. Carcinogenesis. 23:35–45. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Hu T, Ferril S, Snider A and Barbosa M: In-vivo analysis of HPV E7 protein association with pRb, p107 and p130. Int J Oncol. 6:167–174. 1995.PubMed/NCBI

46 

Liu WL, Green N, Seymour LW and Stevenson M: Paclitaxel combined with siRNA targeting HPV16 oncogenes improves cytotoxicity for cervical carcinoma. Cancer Gene Ther. 16:764–775. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Johnson RF and Perkins ND: Nuclear factor-kappaB, p53, and mitochondria: regulation of cellular metabolism and the Warburg effect. Trends Biochem Sci. 37:317–324. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Sun Y, Holley AK and St Clair DK: p53 regulation of energy metabolism and mitochondria regulation of p53 in cancer cells: an insight into the role of manganese superoxide dismutase. Curr Pharm Biotechnol. 14:261–273. 2013. View Article : Google Scholar

49 

Galluzzi L, Morselli E, Kepp O, Tajeddine N and Kroemer G: Targeting p53 to mitochondria for cancer therapy. Cell Cycle. 7:1949–1955. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Yim EK, Tong SY, Ho EM, Bae JH, Um SJ and Park JS: Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells. Oncol Rep. 21:549–557. 2009.PubMed/NCBI

51 

Prasad S, Ravindran J and Aggarwal BB: NF-kappaB and cancer: how intimate is this relationship. Mol Cell Biochem. 336:25–37. 2010. View Article : Google Scholar

52 

Ferris RL and Grandis JR: NF-kappaB gene signatures and p53 mutations in head and neck squamous cell carcinoma. Clin Cancer Res. 13:5663–5664. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Sen T, Dutta A and Chatterjee A: Epigallocatechin-3-gallate (EGCG) downregulates-B (MMP-9) by involvement of FAK/ERK/NFkappa B and AP-1 in the human breast cancer cell line MDA-MB-231. Anticancer Drug. 21:632–644. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Dang Y, Yuan X, Tian R, Li D and Liu W: Curcumin improves the paclitaxel‑induced apoptosis of HPV‑positive human cervical cancer cells via the NF‑κB‑p53‑caspase‑3 pathway Retraction in /10.3892/etm.2025.12902. Exp Ther Med 9: 1470-1476, 2015.
APA
Dang, Y., Yuan, X., Tian, R., Li, D., & Liu, W. (2015). Curcumin improves the paclitaxel‑induced apoptosis of HPV‑positive human cervical cancer cells via the NF‑κB‑p53‑caspase‑3 pathway Retraction in /10.3892/etm.2025.12902. Experimental and Therapeutic Medicine, 9, 1470-1476. https://doi.org/10.3892/etm.2015.2240
MLA
Dang, Y., Yuan, X., Tian, R., Li, D., Liu, W."Curcumin improves the paclitaxel‑induced apoptosis of HPV‑positive human cervical cancer cells via the NF‑κB‑p53‑caspase‑3 pathway Retraction in /10.3892/etm.2025.12902". Experimental and Therapeutic Medicine 9.4 (2015): 1470-1476.
Chicago
Dang, Y., Yuan, X., Tian, R., Li, D., Liu, W."Curcumin improves the paclitaxel‑induced apoptosis of HPV‑positive human cervical cancer cells via the NF‑κB‑p53‑caspase‑3 pathway Retraction in /10.3892/etm.2025.12902". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1470-1476. https://doi.org/10.3892/etm.2015.2240
Copy and paste a formatted citation
x
Spandidos Publications style
Dang Y, Yuan X, Tian R, Li D and Liu W: Curcumin improves the paclitaxel‑induced apoptosis of HPV‑positive human cervical cancer cells via the NF‑κB‑p53‑caspase‑3 pathway Retraction in /10.3892/etm.2025.12902. Exp Ther Med 9: 1470-1476, 2015.
APA
Dang, Y., Yuan, X., Tian, R., Li, D., & Liu, W. (2015). Curcumin improves the paclitaxel‑induced apoptosis of HPV‑positive human cervical cancer cells via the NF‑κB‑p53‑caspase‑3 pathway Retraction in /10.3892/etm.2025.12902. Experimental and Therapeutic Medicine, 9, 1470-1476. https://doi.org/10.3892/etm.2015.2240
MLA
Dang, Y., Yuan, X., Tian, R., Li, D., Liu, W."Curcumin improves the paclitaxel‑induced apoptosis of HPV‑positive human cervical cancer cells via the NF‑κB‑p53‑caspase‑3 pathway Retraction in /10.3892/etm.2025.12902". Experimental and Therapeutic Medicine 9.4 (2015): 1470-1476.
Chicago
Dang, Y., Yuan, X., Tian, R., Li, D., Liu, W."Curcumin improves the paclitaxel‑induced apoptosis of HPV‑positive human cervical cancer cells via the NF‑κB‑p53‑caspase‑3 pathway Retraction in /10.3892/etm.2025.12902". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1470-1476. https://doi.org/10.3892/etm.2015.2240
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