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Article

Primary primitive neuroectodermal tumor arising in the mesentery and ileocecum: A report of three cases and review of the literature

  • Authors:
    • Libo Peng
    • Limin Yang
    • Nan Wu
    • Bo Wu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Jinling Hospital, Clinical Medical School of Southern Medical University, Nanjing, Jiangsu 210002, P.R. China
  • Pages: 1299-1303
    |
    Published online on: January 30, 2015
       https://doi.org/10.3892/etm.2015.2242
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Abstract

Primitive neuroectodermal tumor (PNET) is most commonly encountered in the soft tissue or bone in children and young adults, and its involvement in the intestines is exceedingly rare. To the best of our knowledge, eighteen cases have been reported to date. The present study reports three cases of PNET arising in the mesentery and ileocecum in 59‑ and 22‑year‑old males and a 36‑year‑old female. Computed tomography revealed a solid mass in the lower abdomen, with areas of cystic changes. Microscopically, the tumors were composed of small round cells arranged in sheets and rosettes with scant cytoplasm, hyperchromatic nuclei and a high mitotic rate. The tumor cells were immunopositive for CD99 and FLI1. EWS/FLI1 translocations were detected in all cases. Case 1 and case 2 underwent tumor resection without any preoperative radiotherapy, chemotherapy or biological therapy. Case 3 underwent tumor resection and received eight cycles of IAP chemotherapy (2.0 mg ifosfamide, 80 mg epirubicin, 30 mg cisplatin 30mg). Case 3 was followed up for 34 months until they succumbed to peritoneal recurrence, whereas the other cases were not followed up. The incidence of these small round‑cell tumors in the intestinal system, their clinical and pathological features and differential diagnosis are discussed with a review of the literature.
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Copy and paste a formatted citation
Spandidos Publications style
Peng L, Yang L, Wu N and Wu B: Primary primitive neuroectodermal tumor arising in the mesentery and ileocecum: A report of three cases and review of the literature. Exp Ther Med 9: 1299-1303, 2015.
APA
Peng, L., Yang, L., Wu, N., & Wu, B. (2015). Primary primitive neuroectodermal tumor arising in the mesentery and ileocecum: A report of three cases and review of the literature. Experimental and Therapeutic Medicine, 9, 1299-1303. https://doi.org/10.3892/etm.2015.2242
MLA
Peng, L., Yang, L., Wu, N., Wu, B."Primary primitive neuroectodermal tumor arising in the mesentery and ileocecum: A report of three cases and review of the literature". Experimental and Therapeutic Medicine 9.4 (2015): 1299-1303.
Chicago
Peng, L., Yang, L., Wu, N., Wu, B."Primary primitive neuroectodermal tumor arising in the mesentery and ileocecum: A report of three cases and review of the literature". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1299-1303. https://doi.org/10.3892/etm.2015.2242
Copy and paste a formatted citation
x
Spandidos Publications style
Peng L, Yang L, Wu N and Wu B: Primary primitive neuroectodermal tumor arising in the mesentery and ileocecum: A report of three cases and review of the literature. Exp Ther Med 9: 1299-1303, 2015.
APA
Peng, L., Yang, L., Wu, N., & Wu, B. (2015). Primary primitive neuroectodermal tumor arising in the mesentery and ileocecum: A report of three cases and review of the literature. Experimental and Therapeutic Medicine, 9, 1299-1303. https://doi.org/10.3892/etm.2015.2242
MLA
Peng, L., Yang, L., Wu, N., Wu, B."Primary primitive neuroectodermal tumor arising in the mesentery and ileocecum: A report of three cases and review of the literature". Experimental and Therapeutic Medicine 9.4 (2015): 1299-1303.
Chicago
Peng, L., Yang, L., Wu, N., Wu, B."Primary primitive neuroectodermal tumor arising in the mesentery and ileocecum: A report of three cases and review of the literature". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1299-1303. https://doi.org/10.3892/etm.2015.2242
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