Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2015 Volume 9 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2015 Volume 9 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association between red cell distribution width and the risk of heart events in patients with coronary artery disease

  • Authors:
    • Weimin Li
    • Xiaoting Li
    • Maofeng Wang
    • Xuan Ge
    • Feixiang Li
    • Bian Huang
    • Jiren Peng
    • Guohong Li
    • Liang Lu
    • Zhuoyuan Yu
    • Jiaojiao Ma
    • Liaohang Xu
    • Meijuan Jin
    • Hongping Si
    • Rugen Wan
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang 322100, P.R. China, Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China, Department of Clinical Laboratory Medicine, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang 322100, P.R. China
  • Pages: 1508-1514
    |
    Published online on: January 30, 2015
       https://doi.org/10.3892/etm.2015.2244
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Red cell distribution width (RDW) has been found to be a novel prognostic biomarker in patients with coronary artery disease (CAD); however, the association between RDW and the risk of heart events in patients with CAD is yet to be fully elucidated. Thus, the aim of the present study was to determine whether an elevated RDW was associated with the Framingham risk score (FRS) in patients with CAD. Data were retrospectively collected from Affiliated Dongyang Hospital of Wenzhou Medical University (Dongyang, China). The patients had undergone a coronary angiography and their clinical data were integrated. The patients (male, 260; female, 132) were divided into two groups based on the results of the coronary angiography, namely the CAD (n=283) and control groups (n=109). The FRS was calculated for all the subjects, and complete blood count testing with biochemical measurements was performed. The mean RDW level was 13.7±1.8% in the CAD group and 13.1±1.0% in the control group, while the mean FRS was 9.0±4.9 in the CAD group and 6.4±3.9 in the control group. The RDW and FRS were significantly higher in the CAD group compared with the control group (P<0.001). No statistically significant differences were observed between the groups with regard to the hematocrit, mean corpuscular volume, platelets, glucose, urea, albumin, aspartate aminotransferase, total cholesterol, triglycerides (TG), high‑density lipoprotein cholesterol, low‑density lipoprotein cholesterol and N‑terminal pro‑brain natriuretic peptide (P>0.05). The RDW was shown to significantly correlate with the red blood cell (RBC) count (r=‑0.133, P=0.029), hemoglobin level (r=‑0.207, P=0.001) and TG level (r=0.226, P<0.001) within the laboratory parameters, as well as the FRS (r=0.206, P<0.001). In the stepwise multivariate linear regression, which included the RBC count, hemoglobin level, TG level and RDW, the FRS was predicted by hemoglobin (r2=0.034, P=0.001), TG (r2=0.059, P<0.001) and RDW (r2=0.030, P=0.003) parameters. Therefore, a novel association was revealed between higher levels of RDW and an elevated FRS in patients with CAD, which raises the possibility that a simple marker, RDW, may be associated with an increased risk of heart events in CAD patients.
View Figures

Figure 1

View References

1 

Rhodes CJ, Wharton J, Howard LS, Gibbs JS and Wilkins MR: Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension. Heart. 97:1054–1060. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Sičaja M, Pehar M, Đerek L, et al: Red blood cell distribution width as a prognostic marker of mortality in patients on chronic dialysis: a single center, prospective longitudinal study. Croat Med J. 54:25–32. 2013. View Article : Google Scholar

3 

Chen B, Ye B, Zhang J, Ying L and Chen Y: RDW to platelet ratio: a novel noninvasive index for predicting hepatic fibrosis and cirrhosis in chronic hepatitis B. PLoS One. 8:e687802013. View Article : Google Scholar : PubMed/NCBI

4 

Oh J, Kang SM, Hong N, et al: Relation between red cell distribution width with echocardiographic parameters in patients with acute heart failure. J Card Fail. 15:517–522. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Adams KF Jr, Mehra MR, Oren RM, et al: Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure. Am Heart J. 160:1142–1148. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Isik T, Kurt M, Ayhan E, et al: Relation of red cell distribution width with presence and severity of coronary artery ectasia. Clin Appl Thromb Hemost. 18:441–447. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Warwick R, Mediratta N, Shaw M, et al: Red cell distribution width and coronary artery bypass surgery. Eur J Cardiothorac Surg. 43:1165–1169. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Uyarel H, Ergelen M, Cicek G, et al: Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction. Coron Artery Dis. 22:138–144. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Ujszaszi A, Molnar MZ, Czira ME, Novak M and Mucsi I: Renal function is independently associated with red cell distribution width in kidney transplant recipients: a potential new auxiliary parameter for the clinical evaluation of patients with chronic kidney disease. Br J Haematol. 161:715–725. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Sanz-Peláez O, Angel-Moreno A, Tapia-Martin M, et al: Reference values in the usual laboratory data for sub-Saharan immigrants. Importance in the management of infectious diseases. Rev Clin Esp. 208:386–392. 2008.(In Spanish). View Article : Google Scholar

11 

Karagöz E and Tanoglu A: Red blood cell distribution width: an emerging diagnostic factor of acute appendicitis? World J Emerg Surg. 8:542013. View Article : Google Scholar : PubMed/NCBI

12 

Lee JH, Chung HJ, Kim K, et al: Red cell distribution width as a prognostic marker in patients with community-acquired pneumonia. Am J Emerg Med. 31:72–79. 2013. View Article : Google Scholar

13 

Braun E, Domany E, Kenig Y, Mazor Y, Makhoul BF and Azzam ZS: Elevated red cell distribution width predicts poor outcome in young patients with community acquired pneumonia. Crit Care. 15:R1942011. View Article : Google Scholar : PubMed/NCBI

14 

Hong CH, Falvey C, Harris TB, et al: Anemia and risk of dementia in older adults: findings from the Health ABC study. Neurology. 81:528–533. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Osadnik T, Strzelczyk J, Hawranek M, et al: Red cell distribution width is associated with long-term prognosis in patients with stable coronary artery disease. BMC Cardiovasc Disord. 13:1132013. View Article : Google Scholar : PubMed/NCBI

16 

Isik T, Uyarel H, Tanboga IH, et al: Relation of red cell distribution width with the presence, severity and complexity of coronary artery disease. Coron Artery Dis. 23:51–56. 2012. View Article : Google Scholar

17 

Vorre MM and Abdulla J: Diagnostic accuracy and radiation dose of CT coronary angiography in atrial fibrillation: systematic review and meta-analysis. Radiology. 267:376–386. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Schlattmann P, Schuetz GM and Dewey M: Influence of coronary artery disease prevalence on predictive values of coronary CT angiography: a meta-regression analysis. Eur Radiol. 21:1904–1913. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Rickard J, Kumbhani DJ, Gorodeski EZ, et al: Elevated red cell distribution width is associated with impaired reverse ventricular remodeling and increased mortality in patients undergoing cardiac resynchronization therapy. Congest Heart Fail. 18:79–84. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Özcan F, Turak O, Avci S, et al: Heart rate variability and red cell distribution width in patients with systolic left heart failure. Scand Cardiovasc J. 47:225–229. 2013. View Article : Google Scholar

21 

Olivares Jara M, Santas Olmeda E, Minaña Escrivà G, et al: Red cell distribution width and mortality risk in acute heart failure patients. Med Clin (Barc). 140:433–438. 2013.(In Spanish). View Article : Google Scholar

22 

Zalawadiya SK, Veeranna V, Niraj A, et al: Red cell distribution width and risk of coronary heart disease events. Am J Cardiol. 106:988–993. 2010. View Article : Google Scholar : PubMed/NCBI

23 

McKenney JM: Update on the National Cholesterol Education Program Adult Treatment Panel III guidelines: getting to goal. Pharmacotherapy. 23:S26–S33. 2003. View Article : Google Scholar

24 

Shehata HA, Ali MM, Evans-Jones JC, Upton GJ and Manyonda IT: Red cell distribution width (RDW) changes in pregnancy. Int J Gynaecol Obstet. 62:43–46. 1998. View Article : Google Scholar : PubMed/NCBI

25 

Kucukdurmaz Z, Karavelioglu Y, Karapinar H, et al: Red cell distribution width and hypertensive response to exercise in patients with type 2 diabetes mellitus. Clin Exp Hypertens. 36:32–35. 2014. View Article : Google Scholar

26 

Şenol K, Saylam B, Kocaay F and Tez M: Red cell distribution width as a predictor of mortality in acute pancreatitis. Am J Emerg Med. 31:687–689. 2013. View Article : Google Scholar : PubMed/NCBI

27 

McPherson R and Davies RW: Inflammation and coronary artery disease: insights from genetic studies. Can J Cardiol. 28:662–666. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Santos MJ and Fonseca JE: Metabolic syndrome, inflammation and atherosclerosis-the role of adipokines in health and in systemic inflammatory rheumatic diseases. Acta Reumatol Port. 34:590–598. 2009.

29 

Zambon A, Pauletto P and Crepaldi G: Review article: the metabolic syndrome - a chronic cardiovascular inflammatory condition. Aliment Pharmacol Ther. 22(Suppl 2): 20–23. 2005. View Article : Google Scholar

30 

Tracy RP: Inflammation markers and coronary heart disease. Curr Opin Lipidol. 10:435–441. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G and Guidi GC: Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med. 133:628–632. 2009.PubMed/NCBI

32 

Förhécz Z, Gombos T, Borgulya G, Pozsonyi Z, Prohászka Z and Jánoskuti L: Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function and nutritional state. Am Heart J. 158:659–666. 2009. View Article : Google Scholar

33 

Zalawadiya SK, Veeranna V, Niraj A, Pradhan J and Afonso L: Red cell distribution width and risk of coronary heart disease events. Am J Cardiol. 106:988–993. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Berliner JA, Navab M, Fogelman AM, et al: Atherosclerosis: basic mechanisms. Oxidation, inflammation and genetics. Circulation. 91:2488–2496. 1995. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li W, Li X, Wang M, Ge X, Li F, Huang B, Peng J, Li G, Lu L, Yu Z, Yu Z, et al: Association between red cell distribution width and the risk of heart events in patients with coronary artery disease. Exp Ther Med 9: 1508-1514, 2015.
APA
Li, W., Li, X., Wang, M., Ge, X., Li, F., Huang, B. ... Wan, R. (2015). Association between red cell distribution width and the risk of heart events in patients with coronary artery disease. Experimental and Therapeutic Medicine, 9, 1508-1514. https://doi.org/10.3892/etm.2015.2244
MLA
Li, W., Li, X., Wang, M., Ge, X., Li, F., Huang, B., Peng, J., Li, G., Lu, L., Yu, Z., Ma, J., Xu, L., Jin, M., Si, H., Wan, R."Association between red cell distribution width and the risk of heart events in patients with coronary artery disease". Experimental and Therapeutic Medicine 9.4 (2015): 1508-1514.
Chicago
Li, W., Li, X., Wang, M., Ge, X., Li, F., Huang, B., Peng, J., Li, G., Lu, L., Yu, Z., Ma, J., Xu, L., Jin, M., Si, H., Wan, R."Association between red cell distribution width and the risk of heart events in patients with coronary artery disease". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1508-1514. https://doi.org/10.3892/etm.2015.2244
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Li X, Wang M, Ge X, Li F, Huang B, Peng J, Li G, Lu L, Yu Z, Yu Z, et al: Association between red cell distribution width and the risk of heart events in patients with coronary artery disease. Exp Ther Med 9: 1508-1514, 2015.
APA
Li, W., Li, X., Wang, M., Ge, X., Li, F., Huang, B. ... Wan, R. (2015). Association between red cell distribution width and the risk of heart events in patients with coronary artery disease. Experimental and Therapeutic Medicine, 9, 1508-1514. https://doi.org/10.3892/etm.2015.2244
MLA
Li, W., Li, X., Wang, M., Ge, X., Li, F., Huang, B., Peng, J., Li, G., Lu, L., Yu, Z., Ma, J., Xu, L., Jin, M., Si, H., Wan, R."Association between red cell distribution width and the risk of heart events in patients with coronary artery disease". Experimental and Therapeutic Medicine 9.4 (2015): 1508-1514.
Chicago
Li, W., Li, X., Wang, M., Ge, X., Li, F., Huang, B., Peng, J., Li, G., Lu, L., Yu, Z., Ma, J., Xu, L., Jin, M., Si, H., Wan, R."Association between red cell distribution width and the risk of heart events in patients with coronary artery disease". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1508-1514. https://doi.org/10.3892/etm.2015.2244
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team