Serum levels of specific IgE to Staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis

Cui,Xin‑Yan; Miao,Jian‑Liang; Lu,Han‑Qiang; Qi,Qin‑Hong; Chen,Xi; Xu,Jin; Lin,Zi‑Ping; Chen,Zhi‑Bin; Yin,Min; Cheng,Lei

doi:10.3892/etm.2015.2247

Serum levels of specific IgE to Staphylococcus aureus enterotoxins in patients with chronic rhinosinusitis

Authors:
- Xin‑Yan Cui
- Jian‑Liang Miao
- Han‑Qiang Lu
- Qin‑Hong Qi
- Xi Chen
- Jin Xu
- Zi‑Ping Lin
- Zhi‑Bin Chen
- Min Yin
- Lei Cheng
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Affiliations: Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Allergy Laboratory, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
Published online on: February 2, 2015 https://doi.org/10.3892/etm.2015.2247
Pages: 1523-1527

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Abstract

The aim of this study was to determine the prevalence of Staphylococcus aureus enterotoxins (SEs) in the serum from patients with chronic rhinosinusitis (CRS) and its involvement in the condition. Thirty CRS patients without nasal polyps (CRSsNP), 40 CRS patients with nasal polyps (CRSwNP), and 30 healthy controls were enrolled in this study. Peripheral blood was obtained and analyzed to measure the serum levels of total IgE, specific IgE to SEA, SEB and SEC, and eosinophil cationic protein (ECP) using ImmunoCAP assays. The positive rate and level of serum specific IgE to SEB, but not to SEA or SEC, were significantly higher in CRSwNP patients compared with the controls (P=0.027 and P=0.021, respectively). No significant differences were found between CRSsNP patients and controls, or between CRSsNP and CRSwNP patients. Serum total IgE was significantly elevated and positively correlated with SEB‑specific IgE in the CRSsNP (P<0.001; r=0.393, P=0.032) and CRSwNP (P<0.001; r=0.581, P<0.001) groups. ECP was also significantly increased in the CRSsNP (P=0.002) and CRSwNP (P<0.001) groups, but not correlated with specific IgE to SEs in either CRS group. The results suggest that SEB may play a role in the pathogenesis of CRSwNP.

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