Doxapram hastens the recovery following total intravenous anesthesia with dexmedetomidine, propofol and remifentanil

Wang,Huan‑Liang; Tang,Shu‑Hai; Wang,Xue‑Qin; Gong,Wen‑Hua; Liu,Xiao‑Mei; Lei,Wei‑Fu

doi:10.3892/etm.2015.2249

April-2015 Volume 9 Issue 4

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April-2015 Volume 9 Issue 4

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Article

Doxapram hastens the recovery following total intravenous anesthesia with dexmedetomidine, propofol and remifentanil

Authors:
- Huan‑Liang Wang
- Shu‑Hai Tang
- Xue‑Qin Wang
- Wen‑Hua Gong
- Xiao‑Mei Liu
- Wei‑Fu Lei
View Affiliations / Copyright

Affiliations: Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China
Pages: 1518-1522
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Published online on: February 2, 2015

https://doi.org/10.3892/etm.2015.2249
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Abstract

Dexmedetomidine is a suitable sedative for awake fiberoptic intubation in patients with obstructive sleep apnea (OSA). However, previous studies have shown that dexmedetomidine delays recovery from propofol‑remifentanil anesthesia. This study aimed to determine whether doxapram may hasten the recovery following dexmedotomidine‑propofol‑remifentanil anesthesia. Sixty patients scheduled for uvulopalatopharyngoplasty with total intravenous anesthesia were randomized to two groups according to the medicine given at the end of surgery. These were the doxapram (1 mg/kg) and control (normal saline) groups (n=30 per group). The primary outcome was the time to eye opening on verbal command. The time to return to spontaneous breathing, to hand squeezing in response to verbal command, to extubation of the trachea, and the heart rate (HR), bispectral index (BIS) values, respiratory rate (RR) and pulse oximetry values were also recorded and compared. The time to return to spontaneous breathing (5.2±2.9 vs. 11.7±3.4 min, P<0.001), eye opening (9.3±4.7 vs. 15.9±6.3 min, P<0.001), hand squeeze to command (11.8±6.5 vs. 17.6±7.7 min, P=0.0026) and extubation (14.2±7.8 vs. 19.2±9.6 min, P=0.0308) were significantly shorter in the doxapram group compared with the control group. BIS scores (at 3‑14 min), RR (at 4‑10 min) and HR (at 2‑13 min) were significantly higher in the doxapram group compared with those in the control group (P<0.05). Doxapram hastens the recovery from dexmedetomidine‑propofol‑remifentanil anesthesia in patients undergoing uvulopalatopharyngoplasty, and may benefit patients with OSA.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Doxapram hastens the recovery following total intravenous anesthesia with dexmedetomidine, propofol and remifentanil

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