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April-2015 Volume 9 Issue 4

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Clinical characteristics and therapeutic evaluation of childhood myasthenia gravis

  • Authors:
    • Zhi‑Xiao Yang
    • Kai‑Li Xu
    • Hui Xiong
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    Affiliations: Department of Neurology, Children's Hospital of Zhengzhou, Zhengzhou, Henan 450053, P.R. China, Department of Paediatrics, Peking University First Hospital, Beijing 100034, P.R. China
  • Pages: 1363-1368
    |
    Published online on: February 3, 2015
       https://doi.org/10.3892/etm.2015.2256
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Abstract

This study aimed to analyze the clinical characteristics, classification and treatment of childhood myasthenia gravis (MG) and address the prognosis through follow-up. The clinical data of 135 children with MG were grouped according to clinical type and therapeutic drugs, retrospectively analyzed and prospectively monitored. Of the 135 MG patients, 85.2% had type I (ocular type), with only 4.2% progressing to systemic MG; 13.4% had type II (general type); and 1.5% had type III (fulminating type). Relapse occurred in 46.1% of the 102 patients that were followed up. The positive rate for the primary acetylcholine receptor antibody was 40.19%, without significant differences among clinical subtypes. The positive rate of the repetitive nerve stimulation frequency test by electromyography was 37.97%. Decreased expression of CD4+, CD8+, or CD3+ was present in 71% of the patients. Thymic hyperplasia was present in 5.93% of the patients, while 1.48% had thymoma. Steroid treatment was effective in the majority of the patients. Ocular type MG was common in this cohort of patients. The incidence and mortality of myasthenia crisis were low, the presence of concurrent thymoma was rare and only a limited number of children developed neurological sequelae.
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Copy and paste a formatted citation
Spandidos Publications style
Yang ZX, Xu KL and Xiong H: Clinical characteristics and therapeutic evaluation of childhood myasthenia gravis. Exp Ther Med 9: 1363-1368, 2015.
APA
Yang, Z., Xu, K., & Xiong, H. (2015). Clinical characteristics and therapeutic evaluation of childhood myasthenia gravis. Experimental and Therapeutic Medicine, 9, 1363-1368. https://doi.org/10.3892/etm.2015.2256
MLA
Yang, Z., Xu, K., Xiong, H."Clinical characteristics and therapeutic evaluation of childhood myasthenia gravis". Experimental and Therapeutic Medicine 9.4 (2015): 1363-1368.
Chicago
Yang, Z., Xu, K., Xiong, H."Clinical characteristics and therapeutic evaluation of childhood myasthenia gravis". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1363-1368. https://doi.org/10.3892/etm.2015.2256
Copy and paste a formatted citation
x
Spandidos Publications style
Yang ZX, Xu KL and Xiong H: Clinical characteristics and therapeutic evaluation of childhood myasthenia gravis. Exp Ther Med 9: 1363-1368, 2015.
APA
Yang, Z., Xu, K., & Xiong, H. (2015). Clinical characteristics and therapeutic evaluation of childhood myasthenia gravis. Experimental and Therapeutic Medicine, 9, 1363-1368. https://doi.org/10.3892/etm.2015.2256
MLA
Yang, Z., Xu, K., Xiong, H."Clinical characteristics and therapeutic evaluation of childhood myasthenia gravis". Experimental and Therapeutic Medicine 9.4 (2015): 1363-1368.
Chicago
Yang, Z., Xu, K., Xiong, H."Clinical characteristics and therapeutic evaluation of childhood myasthenia gravis". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1363-1368. https://doi.org/10.3892/etm.2015.2256
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