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Article

Significance of resistin expression in acute pancreatitis

  • Authors:
    • Le‑Ning Xue
    • Xiao‑Yong Wang
    • Yong Tan
    • Min Lin
    • Wei Zhang
    • Ke‑Qun Xu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Changzhou Second Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213003, P.R. China
  • Pages: 1438-1442
    |
    Published online on: February 6, 2015
       https://doi.org/10.3892/etm.2015.2270
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Abstract

The aim of the present study was to detect the expression of resistin in rats with acute pancreatitis (AP) and investigate its significance in the pathogenesis of AP. In total, 40 Sprague‑Dawley rats were randomly divided into four groups (n=10), including the normal control, sham‑operated, acute edematous pancreatitis (AEP) and acute necrotizing pancreatitis (ANP) groups. Following the establishment of animal models, the levels of serum resistin, C‑reactive protein (CRP), tumor necrosis factor‑α (TNF‑α) and interleukin (IL)‑1β were measured using ELISA. Resistin expression in the pancreatic tissues was detected using an immunohistochemical method. In addition, the mRNA expression of resistin in the pancreatic tissues was analyzed with quantitative polymerase chain reaction. The levels of serum amylase, serum resistin, TNF‑α, IL‑1β and CRP were all significantly higher in the AEP and ANP groups when compared with the control and sham‑operated groups (P<0.01), as were the pancreas/body weight ratios and pathological scores of the pancreas. These increases were more significant in the ANP group than in the AEP group (P<0.05). The mRNA expression levels of resistin in the pancreatic tissues were markedly higher in the AEP and ANP groups when compared with the control and sham‑operated groups (P<0.01), particularly in the pancreatic tissues of the ANP group, which exhibited notably higher levels compared with the AEP group. The serum resistin level was found to positively correlate with the serum levels of CRP, TNF‑α and IL‑1β, and the pathological scores of the pancreatic tissues. In conclusion, the results indicated that resistin may be associated with the occurrence and development of AP; thus, the protein may be a valuable indicator for assessing the severity of AP.
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Copy and paste a formatted citation
Spandidos Publications style
Xue LN, Wang XY, Tan Y, Lin M, Zhang W and Xu KQ: Significance of resistin expression in acute pancreatitis. Exp Ther Med 9: 1438-1442, 2015.
APA
Xue, L., Wang, X., Tan, Y., Lin, M., Zhang, W., & Xu, K. (2015). Significance of resistin expression in acute pancreatitis. Experimental and Therapeutic Medicine, 9, 1438-1442. https://doi.org/10.3892/etm.2015.2270
MLA
Xue, L., Wang, X., Tan, Y., Lin, M., Zhang, W., Xu, K."Significance of resistin expression in acute pancreatitis". Experimental and Therapeutic Medicine 9.4 (2015): 1438-1442.
Chicago
Xue, L., Wang, X., Tan, Y., Lin, M., Zhang, W., Xu, K."Significance of resistin expression in acute pancreatitis". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1438-1442. https://doi.org/10.3892/etm.2015.2270
Copy and paste a formatted citation
x
Spandidos Publications style
Xue LN, Wang XY, Tan Y, Lin M, Zhang W and Xu KQ: Significance of resistin expression in acute pancreatitis. Exp Ther Med 9: 1438-1442, 2015.
APA
Xue, L., Wang, X., Tan, Y., Lin, M., Zhang, W., & Xu, K. (2015). Significance of resistin expression in acute pancreatitis. Experimental and Therapeutic Medicine, 9, 1438-1442. https://doi.org/10.3892/etm.2015.2270
MLA
Xue, L., Wang, X., Tan, Y., Lin, M., Zhang, W., Xu, K."Significance of resistin expression in acute pancreatitis". Experimental and Therapeutic Medicine 9.4 (2015): 1438-1442.
Chicago
Xue, L., Wang, X., Tan, Y., Lin, M., Zhang, W., Xu, K."Significance of resistin expression in acute pancreatitis". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1438-1442. https://doi.org/10.3892/etm.2015.2270
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