Effects of vitamins E and C combined with β‑carotene on cognitive function in the elderly

  • Authors:
    • Yonghua Li
    • Shumei Liu
    • Yigang Man
    • Ning Li
    • Yu Zhou
  • View Affiliations

  • Published online on: February 9, 2015     https://doi.org/10.3892/etm.2015.2274
  • Pages: 1489-1493
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Abstract

The aim of the present study was to investigate the effect of vitamins E (VE) and C (VC), combined with β‑carotene (β‑C), on cognitive function in the elderly. A total of 276 elderly subjects completed the prospective study following treatment with VE, VC and different doses of β‑C or with VE only. Cognitive function was assessed by the Mini‑Mental State Examination (MMSE) and Hasegawa Dementia Scale (HDS) tests. The plasma levels of amyloid‑β (Aβ) and estradiol (E2) were determined by radioimmunoassay (RIA). Results from the MMSE and HDS assessments indicated that the treatment strategy of VE and VC combined with β‑C significantly improved cognitive function in the elderly subjects, particularly with higher doses of β‑C. Furthermore, RIA suggested that treatment with these vitamins could markedly reduce plasma Aβ levels and elevate plasma E2 levels. The present findings suggest that treatment with VE, VC and β‑C results in promising improvements in cognitive function in the elderly.
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April-2015
Volume 9 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li Y, Liu S, Man Y, Li N and Zhou Y: Effects of vitamins E and C combined with β‑carotene on cognitive function in the elderly. Exp Ther Med 9: 1489-1493, 2015
APA
Li, Y., Liu, S., Man, Y., Li, N., & Zhou, Y. (2015). Effects of vitamins E and C combined with β‑carotene on cognitive function in the elderly. Experimental and Therapeutic Medicine, 9, 1489-1493. https://doi.org/10.3892/etm.2015.2274
MLA
Li, Y., Liu, S., Man, Y., Li, N., Zhou, Y."Effects of vitamins E and C combined with β‑carotene on cognitive function in the elderly". Experimental and Therapeutic Medicine 9.4 (2015): 1489-1493.
Chicago
Li, Y., Liu, S., Man, Y., Li, N., Zhou, Y."Effects of vitamins E and C combined with β‑carotene on cognitive function in the elderly". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1489-1493. https://doi.org/10.3892/etm.2015.2274