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Review Open Access

Role of the angiopoietin/Tie system in pregnancy (Review)

  • Authors:
    • D. Kappou
    • S. Sifakis
    • A. Konstantinidou
    • N. Papantoniou
    • D. A. Spandidos
  • View Affiliations / Copyright

    Affiliations: First Department of Obstetrics and Gynecology, University of Athens, Athens, Greece, Department of Obstetrics and Gynecology, University of Crete Medical School, Heraklion, Crete, Greece, First Department of Pathology, University of Athens Medical School, Athens, Greece, Third Department of Obstetrics and Gynecology, University of Athens, Athens, Greece, Laboratory of Clinical Virology, University of Crete Medical School, Heraklion, Crete, Greece
    Copyright: © Kappou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1091-1096
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    Published online on: February 9, 2015
       https://doi.org/10.3892/etm.2015.2280
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Abstract

Angiopoietin‑1 and ‑2 are endogenous ligands for the vascular endothelium-specific receptor tyrosine kinase Tie‑2. The angiopoietin/Tie system plays a critical role in the regulation of endothelial cell survival and vascular maturation and stability. Apart from its well‑established role in vascular morphogenesis, emerging data support the involvement of angiopoietins in inflammation and various malignancies. Previous studies have underlined the significance of several angiogenic factors in normal placental development. In addition, angiogenic imbalance is observed in pregnancy complications related to impaired placentation, such as preeclampsia (PE) and intrauterine growth restriction (IUGR). However, there is only limited information available on the role of the angiopoietin/Tie system in the establishment of a competent feto‑maternal vascular system. In this review, we present the current knowledge regarding the role of angiopoietins in normal pregnancy and pregnancy complications.
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Kappou D, Sifakis S, Konstantinidou A, Papantoniou N and Spandidos DA: Role of the angiopoietin/Tie system in pregnancy (Review). Exp Ther Med 9: 1091-1096, 2015.
APA
Kappou, D., Sifakis, S., Konstantinidou, A., Papantoniou, N., & Spandidos, D.A. (2015). Role of the angiopoietin/Tie system in pregnancy (Review). Experimental and Therapeutic Medicine, 9, 1091-1096. https://doi.org/10.3892/etm.2015.2280
MLA
Kappou, D., Sifakis, S., Konstantinidou, A., Papantoniou, N., Spandidos, D. A."Role of the angiopoietin/Tie system in pregnancy (Review)". Experimental and Therapeutic Medicine 9.4 (2015): 1091-1096.
Chicago
Kappou, D., Sifakis, S., Konstantinidou, A., Papantoniou, N., Spandidos, D. A."Role of the angiopoietin/Tie system in pregnancy (Review)". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1091-1096. https://doi.org/10.3892/etm.2015.2280
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Spandidos Publications style
Kappou D, Sifakis S, Konstantinidou A, Papantoniou N and Spandidos DA: Role of the angiopoietin/Tie system in pregnancy (Review). Exp Ther Med 9: 1091-1096, 2015.
APA
Kappou, D., Sifakis, S., Konstantinidou, A., Papantoniou, N., & Spandidos, D.A. (2015). Role of the angiopoietin/Tie system in pregnancy (Review). Experimental and Therapeutic Medicine, 9, 1091-1096. https://doi.org/10.3892/etm.2015.2280
MLA
Kappou, D., Sifakis, S., Konstantinidou, A., Papantoniou, N., Spandidos, D. A."Role of the angiopoietin/Tie system in pregnancy (Review)". Experimental and Therapeutic Medicine 9.4 (2015): 1091-1096.
Chicago
Kappou, D., Sifakis, S., Konstantinidou, A., Papantoniou, N., Spandidos, D. A."Role of the angiopoietin/Tie system in pregnancy (Review)". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1091-1096. https://doi.org/10.3892/etm.2015.2280
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