Prognostic value of excision repair cross-complementation group 1 expression in gastric cancer: A meta-analysis

  • Authors:
    • Peng Song
    • Qin Yin
    • Ming Lu
    • Bo Fu
    • Baolin Wang
    • Qinghong Zhao
  • View Affiliations

  • Published online on: February 11, 2015     https://doi.org/10.3892/etm.2015.2284
  • Pages: 1393-1400
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Abstract

The prognostic impact of excision repair cross‑complementation group 1 (ERCC1) expression in gastric cancer (GC) has been investigated for decades, but has yielded controversial results. The aim of the present study was to provide a precise evaluation of whether the expression levels of ERCC1 are associated with overall survival (OS) in patients with GC. A systematic search of Medline and Embase was conducted. Original studies concerning OS and ERCC1 expression were included for critical appraisal. A total of 15 studies comprising 1,425 patients with GC were identified. The results revealed that high/positive ERCC1 expression was an indicator of poor survival in patients with GC [hazard ratio (HR) 1.48; 95% confidence interval (CI) 1.02‑2.10; P=0.036; I2=83.8%; random‑effects model] compared with low/negative ERCC1 expression. Subgroup analysis indicated that high/positive ERCC1 expression had a significant unfavorable impact on OS in the group of patients evaluated by reverse transcription polymerase chain reaction (RT‑PCR; HR 2.57; 95% CI 1.49‑4.45). Furthermore, high/positive ERCC1 expression was found to be associated with poor survival in patients receiving platinum‑based chemotherapy in the RT‑PCR group (HR 2.13; 95% CI 1.06‑4.27). These data suggest that ERCC1 may be a useful prognostic factor for GC. In addition, low mRNA levels of ERCC1 appear to be associated with a significant favorable OS benefit from platinum‑based chemotherapy.
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April-2015
Volume 9 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Song P, Yin Q, Lu M, Fu B, Wang B and Zhao Q: Prognostic value of excision repair cross-complementation group 1 expression in gastric cancer: A meta-analysis. Exp Ther Med 9: 1393-1400, 2015
APA
Song, P., Yin, Q., Lu, M., Fu, B., Wang, B., & Zhao, Q. (2015). Prognostic value of excision repair cross-complementation group 1 expression in gastric cancer: A meta-analysis. Experimental and Therapeutic Medicine, 9, 1393-1400. https://doi.org/10.3892/etm.2015.2284
MLA
Song, P., Yin, Q., Lu, M., Fu, B., Wang, B., Zhao, Q."Prognostic value of excision repair cross-complementation group 1 expression in gastric cancer: A meta-analysis". Experimental and Therapeutic Medicine 9.4 (2015): 1393-1400.
Chicago
Song, P., Yin, Q., Lu, M., Fu, B., Wang, B., Zhao, Q."Prognostic value of excision repair cross-complementation group 1 expression in gastric cancer: A meta-analysis". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1393-1400. https://doi.org/10.3892/etm.2015.2284