High levels of serum lactate dehydrogenase correlate with the severity and mortality of idiopathic pulmonary arterial hypertension

Hu,En‑Ci; He,Jian‑Guo; Liu,Zhi‑Hong; Ni,Xin‑Hai; Zheng,Ya‑Guo; Gu,Qing; Zhao,Zhi‑Hui; Xiong,Chang‑Ming

doi:10.3892/etm.2015.2376

June-2015 Volume 9 Issue 6

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June-2015 Volume 9 Issue 6

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Article

High levels of serum lactate dehydrogenase correlate with the severity and mortality of idiopathic pulmonary arterial hypertension

Authors:
- En‑Ci Hu
- Jian‑Guo He
- Zhi‑Hong Liu
- Xin‑Hai Ni
- Ya‑Guo Zheng
- Qing Gu
- Zhi‑Hui Zhao
- Chang‑Ming Xiong
View Affiliations / Copyright

Affiliations: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, P.R. China
Pages: 2109-2113
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Published online on: March 20, 2015

https://doi.org/10.3892/etm.2015.2376
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Abstract

Liver dysfunction reflects the status of heart failure, and previous studies have demonstrated that serum lactate dehydrogenase (S‑LDH) levels are increased in patients exhibiting heart failure and liver dysfunction. Right heart failure is a main characteristic of idiopathic pulmonary arterial hypertension (IPAH). The aim of the present study was to assess the prognostic significance of S‑LDH levels in patients with IPAH. S‑LDH levels were determined in 173 patients with IPAH, and these patients were subclassified into two groups according to a defined upper reference limit of S‑LDH (250 IU/l). Right heart catheterization was performed in all patients. A total of 53 patients were found to have elevated S‑LDH to ≥250 IU/l. In a mean follow‑up period of 31.2±17.9 months, 57 patients succumbed. In the group with lower S‑LDH levels (S‑LDH <250 IU/l), 16.7% of the patients succumbed, compared with 69.8% of patients in the group with higher S‑LDH levels (S‑LDH ≥250 IU/l). The Kaplan‑Meier survival curves demonstrated that patients with higher S‑LDH levels had a significantly lower survival rate than did those with lower S‑LDH levels (log‑rank test, P<0.001). Cox proportional hazard analyses identified reduced body mass index, reduced cardiac index, elevated World Health Organization functional class, higher S‑LDH and an absence of PAH‑targeted therapy as significant predictors of adverse outcomes. In conclusion, elevated S‑LDH is a risk factor for mortality in patients with IPAH.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

High levels of serum lactate dehydrogenase correlate with the severity and mortality of idiopathic pulmonary arterial hypertension

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