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Article

Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease

  • Authors:
    • Shize Li
    • Nini Wang
    • Jiyu Lou
    • Xiaoman Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450014, P.R. China, Department of Neurology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhenzhou, Henan 450007, P.R. China, Department of Neurology, The First People's Hospital of Zhengzhou, Zhengzhou, Henan 450004, P.R. China
  • Pages: 2389-2393
    |
    Published online on: March 27, 2015
       https://doi.org/10.3892/etm.2015.2391
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Abstract

The aim of this study was to investigate the expression of β-site APP-cleaving enzyme 1 (BACE1) in the hippocampal tissue of an insulin‑resistant rat model, and thereby explore the roles of BACE1 and insulin resistance (IR) in the pathogenesis of Alzheimer's disease (AD). A total of 36 male Sprague‑Dawley rats, aged 2 months, were randomly divided into three groups. These were an insulin‑resistant (experimental) group, a high fat control group and a blank control group. The cognitive function and behavioral changes of the rats were tested by a Morris water maze experiment. Amyloid β (Aβ) deposition was detected by an immunohistochemical method. The expression levels of BACE1 in the rat hippocampal tissues were detected by enzyme‑linked immunosorbent assay, western blotting and reverse transcription‑quantitative polymerase chain reaction technology. The rats in the experimental group had evident learning and memory impairment, with significantly decreased learning memory. The modeling was successful; in the experimental group, the rats exhibited IR and their glucose metabolism was significantly abnormal. However, there was no characteristic pathology of AD. The expression of BACE1 in the brain tissue of rats in the experimental group was significantly higher than that in high fat control and blank control groups (P<0.01). In conclusion, the expression of BACE1 in the brain tissue of insulin‑resistant rats increased, and IR was indicated to participate in the pathogenesis of AD.
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1 

Chai GS, Duan DX, Ma RH, et al: Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats. Neurosci Bull. 30:923–935. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Wang S and Jia J: Promoter polymorphisms which modulate BACE1 expression are associated with sporadic Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 153B:159–166. 2010.PubMed/NCBI

3 

Pera M, Alcolea D, Sánchez-Valle R, et al: Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease. Acta Neuropathol. 125:201–213. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Tang J, Pei Y and Zhou G: When aging-onset diabetes is coming across with Alzheimer disease: Comparable pathogenesis and therapy. Exp Gerontol. 48:744–750. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Yarchoan M and Arnold SE: Repurposing diabetes drugs for brain insulin resistance in Alzheimer disease. Diabetes. 63:2253–2261. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Ghasemi R, Dargahi L, Haeri A, Moosavi M, Mohamed Z and Ahmadiani A: Brain insulin dysregulation: Implication for neurological and neuropsychiatric disorders. Mol Neurobiol. 47:1045–1065. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Zhang T and Liu Y: Insulin resistance animal model induced by high-energy dietary. Shi Yan Dong Wu Ke Xue. 25:48–51. 2008.[(In Chinese)].

8 

Bromley-Brits K, Deng Y and Song W: Morris water maze test for learning and memory deficits in Alzheimer's disease model mice. J Vis Exp. 53:29202011.PubMed/NCBI

9 

Matsuzaki K: How do membranes initiate Alzheimers Disease? Formation of toxic amyloid fibrils by the amyloid β-protein on ganglioside clusters. Acc Chem Res. 47:2397–2404. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Amaral AI, Teixeira AP, Håkonsen BI, Sonnewald U and Alves PM: A comprehensive metabolic profile of cultured astrocytes using isotopic transient metabolic flux analysis and C-labeled glucose. Front Neuroenergetics. 3:52011. View Article : Google Scholar : PubMed/NCBI

11 

Charron MJ and Vuguin PM: Lack of glucagon receptor signaling and its implications beyond glucose homeostasis. J Endocrinol. 224:R123–R130. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Correia SC, Santos RX, Perry G, Zhu X, Moreira PI and Smith MA: Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease? Ageing Res Rev. 10:264–273. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Lannert H and Hoyer S: Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behav Neurosci. 112:1199–1208. 1998. View Article : Google Scholar : PubMed/NCBI

14 

Lesort M, Jope RS and Johnson GV: Insulin transiently increases tau phosphorylation: Involvement of glycogen synthase kinase-3β and Fyn tyrosine kinase. J Neurochem. 72:576–584. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Jin Y, Fan Y, Yan EZ, Liu Z, Zong ZH and Qi ZM: Effects of sodium ferulate on amyloid-β-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus. Acta Pharmacol Sin. 27:1309–1316. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Kondo M, Tokuda T, Itsukage M, et al: distribution of amyloid burden differs between idiopathic normal pressure hydrocephalus and Alzheimer's disease. Neuroradiol J. 26:41–46. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Chu J, Zhuo JM and Praticò D: Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments. Ann Neurol. 71:57–67. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Chiocco MJ and Lamb BT: Spatial and temporal control of age-related APP processing in genomic-based β-secretase transgenic mice. Neurobiol Aging. 28:75–84. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Vassar R: BACE1 inhibitor drugs in clinical trials for Alzheimers disease. Alzheimers Res Ther. 6:892014. View Article : Google Scholar : PubMed/NCBI

20 

Sonkusare S, Srinivasan K, Kaul C and Ramarao P: Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats. Life Sci. 77:1–14. 2005. View Article : Google Scholar : PubMed/NCBI

21 

de la Monte SM, Tong M, Lester-Coll N, Plater M Jr and Wands JR: Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: Relevance to Alzheimer's disease. J Alzheimers Dis. 10:89–109. 2006.PubMed/NCBI

22 

Grünblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P and Hoyer S: Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. J Neurochem. 101:757–770. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Chabrier MA, Blurton-Jones M, Agazaryan AA, Nerhus JL, Martinez-Coria H and LaFerla FM: Soluble Aβ promotes wild-type tau pathology in vivo. J Neurosci. 32:17345–17350. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Vassar R: β-secretase, APP and Aβ in Alzheimer's disease. Subcell Biochem. 38:79–103. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Yan R and Vassar R: Targeting the β secretase BACE1 for Alzheimer's disease therapy. Lancet Neurol. 13:319–329. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li S, Wang N, Lou J and Zhang X: Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease. Exp Ther Med 9: 2389-2393, 2015.
APA
Li, S., Wang, N., Lou, J., & Zhang, X. (2015). Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease. Experimental and Therapeutic Medicine, 9, 2389-2393. https://doi.org/10.3892/etm.2015.2391
MLA
Li, S., Wang, N., Lou, J., Zhang, X."Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease". Experimental and Therapeutic Medicine 9.6 (2015): 2389-2393.
Chicago
Li, S., Wang, N., Lou, J., Zhang, X."Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2389-2393. https://doi.org/10.3892/etm.2015.2391
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Wang N, Lou J and Zhang X: Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease. Exp Ther Med 9: 2389-2393, 2015.
APA
Li, S., Wang, N., Lou, J., & Zhang, X. (2015). Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease. Experimental and Therapeutic Medicine, 9, 2389-2393. https://doi.org/10.3892/etm.2015.2391
MLA
Li, S., Wang, N., Lou, J., Zhang, X."Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease". Experimental and Therapeutic Medicine 9.6 (2015): 2389-2393.
Chicago
Li, S., Wang, N., Lou, J., Zhang, X."Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2389-2393. https://doi.org/10.3892/etm.2015.2391
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