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Case Report

Langerhans cell histiocytosis with multisystem involvement in an infant: A case report

  • Authors:
    • Lintao Bi
    • Butong Sun
    • Zhenxia Lu
    • Zhangzhen Shi
    • Dan Wang
    • Zhenxing Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
  • Pages: 2137-2140
    |
    Published online on: March 30, 2015
       https://doi.org/10.3892/etm.2015.2396
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Abstract

Langerhans cell histiocytosis (LCH) is a proliferative disease of histiocyte-like cells, with a wide range of clinical presentations that vary from a solitary lesion to more severe multifocal or disseminated lesions. The disease can affect any age group; however, the peak incidence rate is in infants aged between 1 and 3 years‑old. Diagnosis of LCH should be based on the synthetical analysis of clinical presentations, in addition to features of imaging and histopathology. Although certain cases regress spontaneously, other patients require systemic chemotherapy together with the administration of steroids. The present study reports the case of an infant with LDH with multisystem involvement, including that of the bone, skin, orbit, spleen and lungs. The patient received chemotherapy and obtained rapid improvement in the involved systems. A total of 2.5 years after completion of the therapy, the patient still remains in follow‑up and no evidence of active disease has been noted.
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Copy and paste a formatted citation
Spandidos Publications style
Bi L, Sun B, Lu Z, Shi Z, Wang D and Zhu Z: Langerhans cell histiocytosis with multisystem involvement in an infant: A case report. Exp Ther Med 9: 2137-2140, 2015.
APA
Bi, L., Sun, B., Lu, Z., Shi, Z., Wang, D., & Zhu, Z. (2015). Langerhans cell histiocytosis with multisystem involvement in an infant: A case report. Experimental and Therapeutic Medicine, 9, 2137-2140. https://doi.org/10.3892/etm.2015.2396
MLA
Bi, L., Sun, B., Lu, Z., Shi, Z., Wang, D., Zhu, Z."Langerhans cell histiocytosis with multisystem involvement in an infant: A case report". Experimental and Therapeutic Medicine 9.6 (2015): 2137-2140.
Chicago
Bi, L., Sun, B., Lu, Z., Shi, Z., Wang, D., Zhu, Z."Langerhans cell histiocytosis with multisystem involvement in an infant: A case report". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2137-2140. https://doi.org/10.3892/etm.2015.2396
Copy and paste a formatted citation
x
Spandidos Publications style
Bi L, Sun B, Lu Z, Shi Z, Wang D and Zhu Z: Langerhans cell histiocytosis with multisystem involvement in an infant: A case report. Exp Ther Med 9: 2137-2140, 2015.
APA
Bi, L., Sun, B., Lu, Z., Shi, Z., Wang, D., & Zhu, Z. (2015). Langerhans cell histiocytosis with multisystem involvement in an infant: A case report. Experimental and Therapeutic Medicine, 9, 2137-2140. https://doi.org/10.3892/etm.2015.2396
MLA
Bi, L., Sun, B., Lu, Z., Shi, Z., Wang, D., Zhu, Z."Langerhans cell histiocytosis with multisystem involvement in an infant: A case report". Experimental and Therapeutic Medicine 9.6 (2015): 2137-2140.
Chicago
Bi, L., Sun, B., Lu, Z., Shi, Z., Wang, D., Zhu, Z."Langerhans cell histiocytosis with multisystem involvement in an infant: A case report". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2137-2140. https://doi.org/10.3892/etm.2015.2396
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