Effects of different routes of tirofiban injection on the left ventricular function and prognosis of patients with myocardial infarction treated with percutaneous coronary intervention

Zhao,Cuihua; Cheng,Guanchang; He,Ruili; Guo,Hongyu; Li,Yanming; Lu,Xueli; Zhang,Yuan; Qiu,Chunguang

doi:10.3892/etm.2015.2401

June-2015 Volume 9 Issue 6

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

June-2015 Volume 9 Issue 6

Full Size Image

Article

Effects of different routes of tirofiban injection on the left ventricular function and prognosis of patients with myocardial infarction treated with percutaneous coronary intervention

Authors:
- Cuihua Zhao
- Guanchang Cheng
- Ruili He
- Hongyu Guo
- Yanming Li
- Xueli Lu
- Yuan Zhang
- Chunguang Qiu
View Affiliations / Copyright

Affiliations: Department of Cardiology, Henan University Huaihe Hospital, Kaifeng, Henan 475000, P.R. China, Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Pages: 2401-2405
|
Published online on: April 1, 2015

https://doi.org/10.3892/etm.2015.2401
Expand metrics +

Abstract

The aim of this study was to investigate the effect of different routes of tirofiban injection on the function of the left ventricle and the prognosis of patients with myocardial infarction (MI) treated with percutaneous coronary intervention (PCI). Ninety‑five patients with MI treated with PCI were divided into two groups [coronary (n=49) and intravenous (n=46)] according to the injection route. A comparison of the left ventricular function and prognosis was made between the two groups following PCI. The success rate of PCI in the coronary group was 97.96%, which was higher than that in the intravenous group (P<0.05). No significant differences were identified in the platelet count (PLT) and platelet aggregation rate (PAR) between the two groups prior to the tirofiban injection. Following the tirofiban injection, the PLT decreased markedly in both groups, with no significant differences between them. The PAR also decreased significantly in the two groups; however, the value in the coronary group was lower than that in the intravenous group (P<0.05). The improvements in the thrombolysis in MI grades, left ventricular ejection fraction and left ventricular diastolic function were greater in the coronary group than those in the intravenous group (P<0.05). All patients received follow‑up for 30 days and the incidence of bleeding in the coronary group was lower than that in the intravenous group (P<0.05). No significant differences were recorded in the recurrence rates of MI, arrhythmia, myocardial ischemia, thrombocytopenia and mortality between the two groups. In conclusion, the administration of tirofiban into the coronary artery could effectively improve the blood flow, left ventricular function and prognosis of patients with MI treated with PCI.

View Figures

View References

1	Niccoli G, Kharbanda RK, Crea F and Banning AP: No-reflow: Again prevention is better than treatment. Eur Heart J. 31:2449–2455. 2010. View Article : Google Scholar : PubMed/NCBI
2	Zhang D, Wang L, Du J, et al: Effect of intracoronary tirofiban combined with nitroprusside injection through thrombus aspiration catheter during primary percutaneous coronary intervention on acute anterior myocardial infarction patients with heavy thrombosis burden. Zhonghua Xin Xue Guan Bing Za Zhi. 42:25–30. 2014.[(In Chinese)]. PubMed/NCBI
3	Li MW, Zhao XM, Rao LX, et al: The clinical efficacy and safety of fondaparinux combined with tirofiban hydrochloride in patients with acute coronary syndrome undergoing complex percutaneous coronary intervention. Zhonghua Nei Ke Za Zhi. 52:1037–1040. 2013.[(In Chinese)]. PubMed/NCBI
4	Ren LH, Peng JJ, Ye HM, Wang ZY and Chen C: High-dose tirofiban in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary interventio. Zhonghua Yi Xue Za Zhi. 92:1981–1983. 2012.[(In Chinese)]. PubMed/NCBI
5	Li X, Lei Y and Zheng Q: Myocardial infarction caused by coronary artery dissection due to blunt injury: Is thromboaspiration an appropriate treatment. Hellenic J Cardiol. 55:61–64. 2014.PubMed/NCBI
6	He WK, Li MY, Xing XW and Lu DF: The effects of different ways of tirofiban injection on prognosis of the patients with AIM treated with PIC. Shi Yong Yi Xue Za Zhi. 28:2936–2939. 2012.
7	Tong ZC, Li Q, Chen M, et al: Efficacy comparison of combined intracoronary administration of high-dose adenosine and tirofiban versus intracoronary tirofiban during primary percutaneous coronary intervention in patients with acute myocardial infarction. Zhonghua Xin Xue Guan Bing Za Zhi. 41:839–844. 2013.[(In Chinese)]. PubMed/NCBI
8	Zhang Y, Gao CY, Zhu ZY, et al: Efficacy and safety of tirofiban use after successful percutaneous coronary intervention for patients with moderate to high risk non-ST segment elevation acute coronary syndromes. Zhonghua Xin Xue Guan Bing Za Zhi. 41:731–735. 2013.[(In Chinese)]. PubMed/NCBI
9	Gibson CM, Karha J, Giugliano RP, et al: INTEGRITI Study Group: Association of the timing of ST-segment resolution with TIMI myocardial perfusion grade in acute myocardial infarction. Am Heart J. 147:847–852. 2004. View Article : Google Scholar : PubMed/NCBI
10	Qin T, Xie L and Chen MH: Meta-analysis of randomized controlled trials on the efficacy and safety of intracoronary administration of tirofiban for no-reflow phenomenon. BMC Cardiovasc Disord. 13:682013. View Article : Google Scholar : PubMed/NCBI
11	Li W, Fu X, Xue H, et al: Efficacy and safety of standard-dose versus half-dose tirofiban in patients with non-ST elevation acute coronary syndromes undergoing early percutaneous coronary intervention. Cardiovasc Ther. 31:210–214. 2013. View Article : Google Scholar : PubMed/NCBI
12	Zhao YJ, Fu XH, Ma XX, et al: Intracoronary fixed dose of nitroprusside via thrombus aspiration catheter for the prevention of the no-reflow phenomenon following primary percutaneous coronary intervention in acute myocardial infarction. Exp Ther Med. 6:479–484. 2013.PubMed/NCBI
13	Balghith M, Al-Ghamdi A, Zain el H and Al-Saileek A: Intracoronary Reopro During Percutaneous Coronary Intervention In Acute And Stable Patient Can Influence Stent Thrombosis Formation (IRPASST) study. Heart Views. 14:62–67. 2013. View Article : Google Scholar : PubMed/NCBI
14	Tas MH, Simsek Z, Ayan A, et al: Effects of tirofiban maintenance duration on myocardial perfusion defect severity in anterior myocardial infarction. Adv Ther. 30:834–844. 2013. View Article : Google Scholar : PubMed/NCBI
15	Hong TT, Huang J, Driscoll E and Lucchesi BR: The antithrombotic effect of melagatran in combination with clopidogrel and/or aspirin (carotid artery primary thrombosis study). J Cardiovasc Pharmacol. 46:526–533. 2005. View Article : Google Scholar : PubMed/NCBI
16	Zhang Y, Gao C, Liu H, et al: Routine early versus deferred provisional tirofiban treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention. Clin Exp Pharmacol Physiol. 40:289–294. 2013. View Article : Google Scholar : PubMed/NCBI
17	Deshpande NV, Pratiti R, Admane P, Mukherjee D and Mardikar HM: Safety and efficacy of bivalirudin with glycoprotein IIb/IIIa for high-risk percutaneous coronary intervention. Indian Heart J. 64:444–448. 2012. View Article : Google Scholar : PubMed/NCBI
18	Balghith MA: High bolus tirofiban vs abciximab in acute STEMI patients undergoing primary PCI - The Tamip study. Heart Views. 13:85–90. 2012. View Article : Google Scholar : PubMed/NCBI
19	Liu X, Dong P, Xing S, et al: Clinical evaluation of thrombus aspiration combined with tirofiban in patients with acute myocardial infarction with elective percutaneous coronary intervention. J Int Med Res. 41:1532–1540. 2013. View Article : Google Scholar : PubMed/NCBI
20	Jia Z, Guo M, Zhang YQ, Liang HQ and Song Y: Short-term effect of upstream administration in comparison to deferred injection of tirofiban on patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. J Interv Cardiol. 26:332–329. 2013. View Article : Google Scholar : PubMed/NCBI
21	Zhang Q, Qiu JP, Zhang RY, et al: Improved outcomes from transradial over transfemoral access in primary percutaneous coronary intervention for patients with acute ST-segment elevation myocardial infarction and upstream use of tirofiban. Chin Med J (Engl). 126:1063–1068. 2013.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effects of different routes of tirofiban injection on the left ventricular function and prognosis of patients with myocardial infarction treated with percutaneous coronary intervention

This article is mentioned in:

Abstract

Figure 1

Related Articles