Association of gene polymorphisms in ABO blood group chromosomal regions and menstrual disorders

  • Authors:
    • Yong Su
    • Gui‑Lian Kong
    • Ya‑Li Su
    • Yan Zhou
    • Li‑Fang Lv
    • Qiong Wang
    • Bao‑Ping Huang
    • Rui‑Zhi Zheng
    • Quan‑Zhong Li
    • Hui‑Juan Yuan
    • Zhi‑Gang Zhao
  • View Affiliations

  • Published online on: April 8, 2015     https://doi.org/10.3892/etm.2015.2416
  • Pages: 2325-2330
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Abstract

This study aimed to investigate whether single nucleotide polymorphisms (SNPs) located near the gene of the ABO blood group play an important role in the genetic aetiology of menstrual disorders (MDs). Polymerase chain reaction‑ligase detection reaction technology was used to detect eight SNPs near the ABO gene location on the chromosomes in 250 cases of MD and 250 cases of normal menstruation. The differences in the distribution of each genotype, as well as the allele frequency in the normal and control groups, were analysed using Pearson's χ2 test to search for disease‑associated loci. SHEsis software was used to analyse the linkage disequilibrium and haplotype frequencies and to inspect the correlation between haplotypes and the disease. Compared with the control group, the experimental group exhibited statistically significant differences in the genotype distribution frequencies of the rs657152 locus of the ABO blood group gene and the rs17250673 locus of the tumour necrosis factor cofactor 2 (TRAF2) gene, which is located downstream of the ABO gene. The allele distribution frequencies of rs657152 and rs495828 loci in the ABO blood group gene exhibited significant differences between the groups. Dominant and recessive genetic model analysis of each locus revealed that the experimental group exhibited statistically significant differences from the control group in the genotype distribution frequencies of rs657152 and rs495828 loci, respectively. These results indicate that the ABO blood group gene and TRAF2 gene may be a cause of MDs.
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June-2015
Volume 9 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Su Y, Kong GL, Su YL, Zhou Y, Lv LF, Wang Q, Huang BP, Zheng RZ, Li QZ, Yuan HJ, Yuan HJ, et al: Association of gene polymorphisms in ABO blood group chromosomal regions and menstrual disorders. Exp Ther Med 9: 2325-2330, 2015.
APA
Su, Y., Kong, G., Su, Y., Zhou, Y., Lv, L., Wang, Q. ... Zhao, Z. (2015). Association of gene polymorphisms in ABO blood group chromosomal regions and menstrual disorders. Experimental and Therapeutic Medicine, 9, 2325-2330. https://doi.org/10.3892/etm.2015.2416
MLA
Su, Y., Kong, G., Su, Y., Zhou, Y., Lv, L., Wang, Q., Huang, B., Zheng, R., Li, Q., Yuan, H., Zhao, Z."Association of gene polymorphisms in ABO blood group chromosomal regions and menstrual disorders". Experimental and Therapeutic Medicine 9.6 (2015): 2325-2330.
Chicago
Su, Y., Kong, G., Su, Y., Zhou, Y., Lv, L., Wang, Q., Huang, B., Zheng, R., Li, Q., Yuan, H., Zhao, Z."Association of gene polymorphisms in ABO blood group chromosomal regions and menstrual disorders". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2325-2330. https://doi.org/10.3892/etm.2015.2416