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Article

Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis

  • Authors:
    • Xiao Xiao
    • Long Xue
    • Hui-Lin Sheng
    • Zhi-Hui Xiao
  • View Affiliations / Copyright

    Affiliations: Neonatal Department, Children's Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China, Department of Neurosurgery, Yangpu Hospital of The Tongji University School of Medicine, Shanghai 200000, P.R. China, Department of Gynecology and Obstetrics, Putuo Maternity and Infant Hospital, Shanghai 200000, P.R. China
  • Pages: 2331-2338
    |
    Published online on: April 8, 2015
       https://doi.org/10.3892/etm.2015.2417
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Abstract

Experimental data imply that serum C‑reactive protein (CRP) is a marker of general systemic inflammation, and inflammation may have a role in the development of pneumonia. The aim of the present study was to investigate the associations of serum CRP levels in infant patients with pneumonia by meta‑analysis. The Science Citation Index, Cochrane Library, PubMed, Embase, CINAHL, Current Contents and two Chinese (CMB and CNKI) databases were searched. Studies were pooled and standard mean difference (SMD) and the corresponding 95% confidence interval (CI) were calculated. Subgroup analyses and publication bias detection were also conducted. The statistical analysis was conducted using Stata software version 12.0. Serum CRP levels were analyzed in 10 clinical case‑control studies (652 infants with pneumonia and 845 healthy controls); significant differences in serum CRP levels were observed between infants with pneumonia and the healthy controls (SMD=4.41, 95% CI: 3.34‑5.47, P<0.001). Ethnicity‑stratified subgroup analysis detected that high levels of serum CRP may be the main risk factor for infant pneumonia in Asian, African and Caucasian populations (all P<0.05). Serum CRP levels were statistically higher in infants with pneumonia than in healthy infants, and thus serum levels of CRP may have independent diagnostic value for pneumonia in children.
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1 

Diez-Padrisa N, Bassat Q, Machevo S, et al: Procalcitonin and C-reactive protein for invasive bacterial pneumonia diagnosis among children in Mozambique, a malaria-endemic area. PLoS One. 5:e132262010. View Article : Google Scholar : PubMed/NCBI

2 

Banstola A and Banstola A: The epidemiology of hospitalization for pneumonia in children under five in the rural western region of Nepal: a descriptive study. PLoS One. 8:e713112013. View Article : Google Scholar : PubMed/NCBI

3 

Seif El Dien HM and Abd ElLatif DAK: The value of bedside Lung Ultrasonography in diagnosis of neonatal pneumonia. Egypt J Radiol Nucl Med. 44:339–347. 2013. View Article : Google Scholar

4 

Zaidi AKM, Ganatra HA, Syed S, et al: Effect of case management on neonatal mortality due to sepsis and pneumonia. BMC Public Health. 11 (Suppl 3):132011. View Article : Google Scholar : PubMed/NCBI

5 

Falade AG and Ayede AI: Epidemiology, aetiology and management of childhood acute community-acquired pneumonia in developing countries - a review. Afr J Med Med Sci. 40:293–308. 2011.PubMed/NCBI

6 

Nissen MD: Congenital and neonatal pneumonia. Paediatr Respir Rev. 8:195–203. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Bang AT, Bang RA, Morankar VP, Sontakke PG and Solanki JM: Pneumonia in neonates: can it be managed in the community? Arch Dis Child. 68:550–556. 1993. View Article : Google Scholar : PubMed/NCBI

8 

Hansen AB, Verder H and Staun-Olsen P: Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns. J Perinat Med. 28:97–103. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Swede H, Hajduk AM, Sharma J, et al: Baseline serum C-reactive protein and death from colorectal cancer in the NHANES III cohort. Int J Cancer. 134:1862–1870. 2014. View Article : Google Scholar : PubMed/NCBI

10 

McDade TW, Rutherford J, Adair L and Kuzawa CW: Early origins of inflammation: microbial exposures in infancy predict lower levels of C-reactive protein in adulthood. Proc Biol Sci. 277:1129–1137. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Jordan KK, Christensen IJ, Heilmann C, Sengelov H and Muller KG: Pretransplant C-reactive protein as a prognostic marker in allogeneic stem cell transplantation. Scand J Immunol. 79:206–213. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Mukerji R, Mirza S, Roche AM, et al: Pneumococcal surface protein A inhibits complement deposition on the pneumococcal surface by competing with the binding of C-reactive protein to cell-surface phosphocholine. J Immunol. 189:5327–5335. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Lu J, Marjon KD, Marnell LL, et al: Recognition and functional activation of the human IgA receptor (FcalphaRI) by C-reactive protein. Proc Natl Acad Sci USA. 108:4974–4979. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Martins OM, Fonseca VF, Borges I, Martins V, Portal VL and Pellanda LC: C-Reactive protein predicts acute myocardial infarction during high-risk noncardiac and vascular surgery. Clinics (Sao Paulo). 66:773–776. 2011.PubMed/NCBI

15 

Jones G, Sebba A, Gu J, et al: Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. Ann Rheum Dis. 69:88–96. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Beisswenger PJ, Brown WV, Ceriello A, et al: Meal-induced increases in C-reactive protein, interleukin-6 and tumour necrosis factor α are attenuated by prandial + basal insulin in patients with Type 2 diabetes. Diabet Med. 28:1088–1095. 2011. View Article : Google Scholar : PubMed/NCBI

17 

van Wijk DF, Boekholdt SM, Wareham NJ, et al: C-reactive protein, fatal and nonfatal coronary artery disease, stroke and peripheral artery disease in the prospective EPIC-Norfolk cohort study. Arterioscler Thromb Vasc Biol. 33:2888–2894. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Emerging Risk Factors Collaboration, . Kaptoge S, Di Angelantonio E, Lowe G, et al: C-reactive protein concentration and risk of coronary heart disease, stroke and mortality: an individual participant meta-analysis. Lancet. 375:132–140. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Huang X, Zhang J, Liu J, et al: C-reactive protein promotes adhesion of monocytes to endothelial cells via NADPH oxidase-mediated oxidative stress. J Cell Biochem. 113:857–867. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Mogelvang R, Pedersen SH, Flyvbjerg A, et al: Comparison of osteoprotegerin to traditional atherosclerotic risk factors and high-sensitivity C-reactive protein for diagnosis of atherosclerosis. Am J Cardiol. 109:515–520. 2012. View Article : Google Scholar : PubMed/NCBI

21 

van Vugt SF, Broekhuizen BD, Lammens C, et al: Grace consortium: Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study. BMJ. 346:F24502013. View Article : Google Scholar : PubMed/NCBI

22 

Hillas G, Vassilakopoulos T, Plantza P, et al: C-reactive protein and procalcitonin as predictors of survival and septic shock in ventilator-associated pneumonia. Eur Respir J. 35:805–811. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Diez-Padrisa N, Bassat Q, Morais L, et al: Procalcitonin and C-reactive protein as predictors of blood culture positivity among hospitalised children with severe pneumonia in Mozambique. Trop Med Int Health. 17:1100–1107. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Koster MJ, Broekhuizen BD, Minnaard MC, et al: Diagnostic properties of C-reactive protein for detecting pneumonia in children. Respir Med. 107:1087–1093. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Xu XY and Li ZF: Value of detection of procalcitonin and C-reactive protein in diagnosis of infectious pneumonia in neonates. Zhonghua Yi Yuan Gan Ran Xue Za Zhi. 23:2515–2517. 2013.(In Chinese).

26 

Zhang GH, Chen CX and He JQ: Study on the correction between the serum SIL-2R, CRP, myocardial enzyme and neonatal pneumonia. Zhongguo Yi Yao Dao Bao. 9:75–76. 2012.(In Chinese).

27 

Badr MA, Ali YF, Albanna EA, Beshir MR and Amr GE: Ventilator associated pneumonia in critically-ill neonates admitted to neonatal intensive care unit, Zagazig University Hospitals. Iran J Pediatr. 21:418–424. 2011.PubMed/NCBI

28 

Salzer HR, Pollak A, Herkner K, Weninger M and Schemper W: Value of measurement of neutrophil elastase-alpha 1 proteinase inhibitor levels in the early diagnosis of neonatal infection. Eur J Clin Microbiol Infect Dis. 12:553–556. 1993. View Article : Google Scholar : PubMed/NCBI

29 

Ben Shimol S, Dagan R, Givon-Lavi N, et al: Evaluation of the World Health Organization criteria for chest radiographs for pneumonia diagnosis in children. Eur J Pediatr. 171:369–374. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Stang A: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 25:603–605. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Jackson D, White IR and Riley RD: Quantifying the impact of between-study heterogeneity in multivariate meta-analyses. Stat Med. 31:3805–3820. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Peters JL, Sutton AJ, Jones DR, Abrams KR and Rushton L: Comparison of two methods to detect publication bias in meta-analysis. JAMA. 295:676–680. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Zintzaras E and Ioannidis JP: HEGESMA: genome search meta-analysis and heterogeneity testing. Bioinformatics. 21:3672–3673. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Feng ZM, Li X and Yang RG: Analysis on detection results of blood lactic acid and C-reactive protein in pneumonic neonates. Zhongguo Yi Yao Dao Bao. 8:85–86. 2011.(In Chinese).

35 

Wu HM: Value of detection of PCT, hs-CRP and WBC in diagnosis of early neonatal pneumonia. Haixia Yufang Yixue Zazhi. 19:83–84. 2013.(In Chinese).

36 

Yang JH, Wei XS and Liao B: Significance of the detection of PCT, hs-CRP and IL-6 in diagnosis of neonatal pneumonia. Chongqing Yixue. 36:1194–1195. 2007.(In Chinese).

37 

Zhou H: Significance of joint detection serum cystatin cand CRP in neonatal pneumonia. Chengde Yixueyuan Xuebao. 31:31–32. 2014.(In Chinese).

38 

Døllner H, Vatten L and Austgulen R: Early diagnostic markers for neonatal sepsis: comparing C-reactive protein, interleukin-6, soluble tumour necrosis factor receptors and soluble adhesion molecules. J Clin Epidemiol. 54:1251–1257. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Romagnoli C, Frezza S, Cingolani A, et al: Plasma levels of interleukin-6 and interleukin-10 in preterm neonates evaluated for sepsis. Eur J Pediatr. 160:345–350. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Volanakis JE: Human C-reactive protein: expression, structure and function. Mol Immunol. 38:189–197. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Arinzon Z, Peisakh A, Schrire S and Berner Y: C-reactive protein (CRP): an important diagnostic and prognostic tool in nursing-home-associated pneumonia. Arch Gerontol Geriatr. 53:364–369. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Moreno MS, Nietmann H, Matias CM and Lobo SM: C-reactive protein: a tool in the follow-up of nosocomial pneumonia. J Infect. 61:205–211. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Marnell L, Mold C and Du Clos TW: C-reactive protein: ligands, receptors and role in inflammation. Clin Immunol. 117:104–111. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K and Campbell H: Epidemiology and etiology of childhood pneumonia. Bull World Health Organ. 86:408–416. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Mintegi S, Benito J, Pijoan JI, et al: Occult pneumonia in infants with high fever without source: a prospective multicenter study. Pediatr Emerg Care. 26:470–474. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiao X, Xue L, Sheng H and Xiao Z: Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis. Exp Ther Med 9: 2331-2338, 2015.
APA
Xiao, X., Xue, L., Sheng, H., & Xiao, Z. (2015). Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis. Experimental and Therapeutic Medicine, 9, 2331-2338. https://doi.org/10.3892/etm.2015.2417
MLA
Xiao, X., Xue, L., Sheng, H., Xiao, Z."Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis". Experimental and Therapeutic Medicine 9.6 (2015): 2331-2338.
Chicago
Xiao, X., Xue, L., Sheng, H., Xiao, Z."Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2331-2338. https://doi.org/10.3892/etm.2015.2417
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao X, Xue L, Sheng H and Xiao Z: Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis. Exp Ther Med 9: 2331-2338, 2015.
APA
Xiao, X., Xue, L., Sheng, H., & Xiao, Z. (2015). Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis. Experimental and Therapeutic Medicine, 9, 2331-2338. https://doi.org/10.3892/etm.2015.2417
MLA
Xiao, X., Xue, L., Sheng, H., Xiao, Z."Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis". Experimental and Therapeutic Medicine 9.6 (2015): 2331-2338.
Chicago
Xiao, X., Xue, L., Sheng, H., Xiao, Z."Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2331-2338. https://doi.org/10.3892/etm.2015.2417
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