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Case Report Open Access

Extensive bone metastases as the initial symptom of papillary thyroid microcarcinoma: A case report

  • Authors:
    • Wei Zheng
    • Jian Tan
    • Guizhi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2104-2108
    |
    Published online on: April 14, 2015
       https://doi.org/10.3892/etm.2015.2423
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Abstract

A 53-year-old female patient presented with lumbar and pelvic pain. The 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography scintigraphy showed extensive bone destruction with hypermetabolic osteolysis, with increased 18F‑FDG uptake. The histological examination of the pubic bone lesion revealed a metastatic tumor. Neither chemotherapy nor radiotherapy could control the condition. More than a year later, the patient underwent a total thyroidectomy with cervical lymph node clearance. The histological examination revealed a papillary thyroid microcarcinoma (PTMC) in the left lobe with capsular invasion. 131I treatment with thyroid hormone withdrawal followed. The 131I whole‑body scintigraphy showed extensive uptake in the basic thyroid deposits, most bones and both lungs. Three months after the 131I treatment, the patient succumbed to cachexia. The present case indicated that not all PTMCs have excellent prognosis and that, despite being rare, clinically significant metastases can arise from a PTMC.
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1 

LiVolsi VA, Albores-Saavedra J, Asa SL, et al: Papillary CarcinomaPathology and Genetics of Tumours of Endocrine Organs. World Health Organization Classification of Tumours. DeLellis RA, Lloyd RV, Heitz PU and Eng C: 8. Third. IARC Press; Lyon: pp. 57–66. 2004

2 

Ito Y, Tomoda C, Uruno T, et al: Papillary microcarcinoma of the thyroid: How should it be treated? World J Surg. 28:1115–1121. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Sorrentino F, Atzeni J, Romano G, Buscemi G and Romano M: Differentiated microcarcinoma of the thyroid gland. G Chir. 31:2772782010.(In Italian). PubMed/NCBI

4 

Cho JK, Kim JY, Jeong CY, Jung EJ, Park ST, Jeong SH, et al: Clinical features and prognostic factors in papillary thyroid microcarcinoma depends on age. J Korean Surg Soc. 82:281–287. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Page C, Biet A, Boute P, Cuvelier P and Strunski V: ‘Aggressive papillary’ thyroid microcarcinoma. Eur Arch Otorhinolaryngol. 266:1959–1963. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Mercante G, Frasoldati A, Pedroni C, et al: Prognostic factors affecting neck lymph node recurrence and distant metastasis in papillary microcarcinoma of the thyroid: Results of a study in 445 patients. Thyroid. 19:707–716. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Yu XM, Wan Y, Sippel RS and Chen H: Should all papillary thyroid microcarcinomas be aggressively treated? An analysis of 18,445 cases. Ann Surg. 254:653–660. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Cappelli C, Castellano M, Braga M, et al: Aggressiveness and outcome of papillary thyroid carcinoma (PTC) versus microcarcinoma (PMC): A mono-institutional experience. J Surg Oncol. 95:555–560. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Basolo F, Torregrossa L, Giannini R, et al: Correlation between the BRAF V600E mutation and tumor invasiveness in papillary thyroid carcinomas smaller than 20 millimeters: Analysis of 1060 cases. J Clin Endocrinol Metab. 95:4197–4205. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Lee KJ, Cho YJ, Kim SJ, et al: Analysis of the clinicopathologic features of papillary thyroid microcarcinoma based on 7-mm tumor size. World J Surg. 35:318–323. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Vasileiadis I, Karakostas E, Charitoudis G, et al: Papillary thyroid microcarcinoma: Clinicopathological characteristics and implications for treatment in 276 patients. Eur J Clin Invest. 42:657–664. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Zhang L, Wei WJ, Ji QH, Zhu YX, Wang ZY, Wang Y, et al: Risk factors for neck nodal metastasis in papillary thyroid microcarcinoma: A study of 1066 patients. J Clin Endocrinol Metab. 97:1250–1257. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Kim HY, Park WY, Lee KE, Park WS, Chung YS, Cho SJ and Youn YK: Comparative analysis of gene expression profiles of papillary thyroid microcarcinoma and papillary thyroid carcinoma. J Cancer Res Ther. 6:452–457. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Arora N, Turbendian HK, Kato MA, Moo TA, Zarnegar R and Fahey TJ III: Papillary thyroid carcinoma and microcarcinoma: Is there a need to distinguish the two? Thyroid. 19:473–477. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Orsenigo E, Beretta E, Fiacco E, Scaltrini F, Veronesi P, Invernizzi L, et al: Management of papillary microcarcinoma of the thyroid gland. Eur J Surg Oncol. 30:1104–1106. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Yu XM, Wan Y, Sippel RS and Chen H: Should all papillary thyroid microcarcinomas be aggressively treated? An analysis of 18,445 cases. Ann Surg. 254:653–660. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Dietlein M, Luyken WA, Schicha H and Larena-Avellaneda A: Incidental multifocal papillary microcarcinomas of the thyroid: Is subtotal thyroidectomy combined with radioiodine ablation enough? Nucl Med Commun. 26:3–8. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Sakorafas GH, Giotakis J and Stafyla V: Papillary thyroid microcarcinoma: A surgical perspective. Cancer Treat Rev. 31:423–438. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zheng W, Tan J and Zhang G: Extensive bone metastases as the initial symptom of papillary thyroid microcarcinoma: A case report. Exp Ther Med 9: 2104-2108, 2015.
APA
Zheng, W., Tan, J., & Zhang, G. (2015). Extensive bone metastases as the initial symptom of papillary thyroid microcarcinoma: A case report. Experimental and Therapeutic Medicine, 9, 2104-2108. https://doi.org/10.3892/etm.2015.2423
MLA
Zheng, W., Tan, J., Zhang, G."Extensive bone metastases as the initial symptom of papillary thyroid microcarcinoma: A case report". Experimental and Therapeutic Medicine 9.6 (2015): 2104-2108.
Chicago
Zheng, W., Tan, J., Zhang, G."Extensive bone metastases as the initial symptom of papillary thyroid microcarcinoma: A case report". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2104-2108. https://doi.org/10.3892/etm.2015.2423
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng W, Tan J and Zhang G: Extensive bone metastases as the initial symptom of papillary thyroid microcarcinoma: A case report. Exp Ther Med 9: 2104-2108, 2015.
APA
Zheng, W., Tan, J., & Zhang, G. (2015). Extensive bone metastases as the initial symptom of papillary thyroid microcarcinoma: A case report. Experimental and Therapeutic Medicine, 9, 2104-2108. https://doi.org/10.3892/etm.2015.2423
MLA
Zheng, W., Tan, J., Zhang, G."Extensive bone metastases as the initial symptom of papillary thyroid microcarcinoma: A case report". Experimental and Therapeutic Medicine 9.6 (2015): 2104-2108.
Chicago
Zheng, W., Tan, J., Zhang, G."Extensive bone metastases as the initial symptom of papillary thyroid microcarcinoma: A case report". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2104-2108. https://doi.org/10.3892/etm.2015.2423
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