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Article

Differentiation between Graves' disease and painless thyroiditis by diffusion-weighted imaging, thyroid iodine uptake, thyroid scintigraphy and serum parameters

  • Authors:
    • Zhaowei Meng
    • Guizhi Zhang
    • Haoran Sun
    • Jian Tan
    • Chunshun Yu
    • Weijun Tian
    • Weidong Li
    • Zhiqiang Yang
    • Mei Zhu
    • Qing He
    • Yujie Zhang
    • Shugao Han
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Endocrinology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Pathology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
  • Pages: 2165-2172
    |
    Published online on: April 17, 2015
       https://doi.org/10.3892/etm.2015.2430
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Abstract

The aim of the present study was to assess the apparent diffusion coefficient (ADC) in diffusion-weighted imaging (DWI), thyroid radioactive iodine uptake (RAIU), thyroid scintigraphy and thyrotropin receptor antibody (TRAb) levels in the differential diagnosis between Graves' disease (GD) and painless thyroiditis (PT). A total of 102 patients with GD and 37 patients with PT were enrolled in the study. DWI was obtained with a 3.0‑T magnetic resonance scanner, and ADC values were calculated. RAIU and thyroid scintigraphy were performed. Tissue samples were obtained from patients with GD (6 cases) following thyroidectomy, and from patients with PT (2 cases) following biopsy. Receiver operating characteristic (ROC) curves were drawn, optimal cut‑off values were selected, and the sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were assessed. It was found that the ADC, TRAb and RAIU were significantly higher in GD than in PT (P<0.05). ROC curves showed areas under the curves for RAIU, ADC and TRAb that were >0.900. RAIU was the reference method. Sensitivity, specificity, accuracy, PPV and NPV were 96.078, 91.892, 95.000, 97.059 and 89.474% for ADC, and 88.235, 75.676, 84.892, 90.909 and 70.000% for TRAb, after the optimal thresholds of 1.837x10‑3 mm2/sec and 1.350 IU/ml were determined respectively. Histopathology showed that tissue cellularity in PT was much higher than in GD due to massive lymphocytic infiltration. The results of the present study indicate that RAIU, ADC and TRAb are of diagnostic value for differentiating between GD and PT. DWI has great potential for thyroid pathophysiological imaging because it reflects differences in tissue cellularity between GD and PT.
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1 

Bahn Chair RS, Burch HB, Cooper DS, et al: American Thyroid Association; American Association of Clinical Endocrinologists: Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 21:593–646. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Izumi Y, Takeoka K and Amino N: Usefulness of the 2nd generation assay for anti-TSH receptor antibodies to differentiate relapse of Graves ‘thyrotoxicosis from development of painless thyroiditis after antithyroid drug treatment for Graves’ disease. Endocr J. 52:493–497. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Kamijo K, Murayama H, Uzu T, Togashi K and Kahaly GJ: A novel bioreporter assay for thyrotropin receptor antibodies using a chimeric thyrotropin receptor (Mc4) is more useful in differentiation of Graves' disease from painless thyroiditis than conventional thyrotropin-stimulating antibody assay using porcine thyroid cells. Thyroid. 20:851–856. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Kubota S, Tamai H, Ohye H, et al: Transient hyperthyroidism after withdrawal of antithyroid drugs in patients with Graves' disease. Endocr J. 51:213–217. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Iitaka M, Morgenthaler NG, Momotani N, et al: Stimulation of thyroid-stimulating hormone (TSH) receptor antibody production following painless thyroiditis. Clin Endocrinol (Oxf). 60:49–53. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Misaki T, Miyamoto S, Kasagi K, Mori T and Konishi J: Serial occurrence of two types of postpartum thyroid disorders. Usefulness of Tc-99m pertechnetate uptake. Clin Nucl Med. 21:460–462. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Nagai Y, Toya T, Fukuoka K, et al: Occurrence and spontaneous remission of Graves' hyperthyroidism preceded by painless thyroiditis. Endocr J. 44:881–885. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Sarlis NJ, Brucker-Davis F, Swift JP, Tahara K and Kohn LD: Graves' disease following thyrotoxic painless thyroiditis. Analysis of antibody activities against the thyrotropin receptor in two cases. Thyroid. 7:829–836. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Umena S, Takano T, Iijima T, et al: A case of repeated painless thyroiditis followed by Graves' disease. Endocr J. 42:821–826. 1995. View Article : Google Scholar : PubMed/NCBI

10 

Ho SC, Eng PH, Fok AC, Ng DC and Khoo DH: Thyrotoxicosis due to the simultaneous occurrence of silent thyroiditis and Graves' disease. Thyroid. 9:1127–1132. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Hiraiwa T, Ito M, Imagawa A, et al: High diagnostic value of a radioiodine uptake test with and without iodine restriction in Graves' disease and silent thyroiditis. Thyroid. 14:531–535. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Kidokoro-Kunii Y, Emoto N, Cho K and Oikawa S: Analysis of the factors associated with Tc-99m pertechnetate uptake in thyrotoxicosis and Graves' disease. J Nippon Med Sch. 73:10–17. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Osaki Y, Sakurai K, Arihara Z, Hata M and Fukazawa H: Prediction of late (24-h) radioactive iodine uptake using early (3-hour) uptake values in Japanese patients with Graves' disease. Endocr J. 59:173–177. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Morris LF, Waxman AD and Braunstein GD: Accuracy considerations when using early (four-or six-h) radioactive iodine uptake to predict twenty-four-hour values for radioactive iodine dosage in the treatment of Graves' disease. Thyroid. 10:779–787. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Kamijo K: Study on cutoff value setting for differential diagnosis between Graves' disease and painless thyroiditis using the TRAb (Elecsys TRAb) measurement via the fully automated electrochemiluminescence immunoassay system. Endocr J. 57:895–902. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Yoshimura Noh J, Miyazaki N, Ito K, et al: Evaluation of a new rapid and fully automated electrochemiluminescence immunoassay for thyrotropin receptor autoantibodies. Thyroid. 18:1157–1164. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Ilicki A, Gamstedt A and Karlsson FA: Hyperthyroid Graves' disease without detectable thyrotropin receptor antibodies. J Clin Endocrinol Metab. 74:1090–1094. 1992. View Article : Google Scholar : PubMed/NCBI

18 

Costagliola S, Morgenthaler NG, Hoermann R, et al: Second generation assay for thyrotropin receptor antibodies has superior diagnostic sensitivity for Graves' disease. J Clin Endocrinol Metab. 84:90–97. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Morita T, Tamai H, Oshima A, et al: The occurrence of thyrotropin binding-inhibiting immunoglobulins and thyroid-stimulating antibodies in patients with silent thyroiditis. J Clin Endocrinol Metab. 71:1051–1055. 1990. View Article : Google Scholar : PubMed/NCBI

20 

Amino N, Yabu Y, Miyai K, et al: Differentiation of thyrotoxicosis induced by thyroid destruction from Graves' disease. Lancet. 2:344–346. 1978. View Article : Google Scholar : PubMed/NCBI

21 

Izumi Y, Hidaka Y, Tada H, et al: Simple and practical parameters for differentiation between destruction-induced thyrotoxicosis and Graves' thyrotoxicosis. Clin Endocrinol (Oxf). 57:51–58. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Ota H, Amino N, Morita S, et al: Quantitative measurement of thyroid blood flow for differentiation of painless thyroiditis from Graves' disease. Clin Endocrinol (Oxf). 67:41–45. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Tezuka M, Murata Y, Ishida R, et al: MR imaging of the thyroid: correlation between apparent diffusion coefficient and thyroid gland scintigraphy. J Magn Reson Imaging. 17:163–169. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Zheng W, Jian T, Guizhi Z, Zhaowei M and Renfei W: Analysis of 13 I therapy and correlation factors of Graves' disease patients: A 4-year retrospective study. Nucl Med Commun. 33:97–101. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Wang RF, Tan J, Zhang GZ, Meng ZW and Zheng W: A comparative study of influential factors correlating with early and late hypothyroidism after 131I therapy for Graves' disease. Chin Med J (Engl). 123:1528–1532. 2010.PubMed/NCBI

26 

Vitug AC and Goldman JM: Silent (painless) thyroiditis: Evidence of a geographic variation in frequency. Arch Intern Med. 145:473–475. 1985. View Article : Google Scholar : PubMed/NCBI

27 

Meng Z, Zhu M and Tan J: Elephantiasis legs. Am J Med Sci. 347:2482014. View Article : Google Scholar : PubMed/NCBI

28 

Mittra ES and McDougall IR: Recurrent silent thyroiditis: A report of four patients and review of the literature. Tfhyroid. 17:671–675. 2007. View Article : Google Scholar

29 

LiVolsi VA: The pathology of autoimmune thyroid disease: A review. Thyroid. 4:333–339. 1994. View Article : Google Scholar : PubMed/NCBI

30 

Malayeri AA, El Khouli RH, Zaheer A, et al: Principles and applications of diffusion-weighted imaging in cancer detection, staging and treatment follow-up. Radiographics. 31:1773–1791. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Woodhams R, Ramadan S, Stanwell P, et al: Diffusion-weighted imaging of the breast: Principles and clinical applications. Radiographics. 31:1059–1084. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Padhani AR, Liu G, Koh DM, et al: Diffusion-weighted magnetic resonance imaging as a cancer biomarker: Consensus and recommendations. Neoplasia. 11:102–125. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Liu Z and Xiao X: The use of multi b values diffusion-weighted imaging in patients with acute stroke. Neuroradiology. 55:371–376. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Della Nave R, Foresti S, Tessa C, et al: ADC mapping of neurodegeneration in the brainstem and cerebellum of patients with progressive ataxias. Neuroimage. 22:698–705. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Pienaar R, Paldino MJ, Madan N, et al: A quantitative method for correlating observations of decreased apparent diffusion coefficient with elevated cerebral blood perfusion in newborns presenting cerebral ischemic insults. Neuroimage. 63:1510–1518. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Forbes KP, Pipe JG, Karis JP and Heiserman JE: Improved image quality and detection of acute cerebral infarction with PROPELLER diffusion-weighted MR imaging. Radiology. 225:551–555. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Ahn SJ, Park MS, Kim KA, et al: 18F-FDG PET metabolic parameters and MRI perfusion and diffusion parameters in hepatocellular carcinoma: A preliminary study. PLoS One. 8:e715712013. View Article : Google Scholar : PubMed/NCBI

38 

Choi SH, Paeng JC, Sohn CH, et al: Correlation of 18F-FDG uptake with apparent diffusion coefficient ratio measured on standard and high b value diffusion MRI in head and neck cancer. J Nucl Med. 52:1056–1062. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Fruehwald-Pallamar J, Czerny C, Mayerhoefer ME, et al: Functional imaging in head and neck squamous cell carcinoma: Correlation of PET/CT and diffusion-weighted imaging at 3 Tesla. Eur J Nucl Med Mol Imaging. 38:1009–1019. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Nakajo M, Kajiya Y, Tani A, et al: FDG PET/CT and diffusion-weighted imaging of head and neck squamous cell carcinoma: Comparison of prognostic significance between primary tumor standardized uptake value and apparent diffusion coefficient. Clin Nucl Med. 37:475–480. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Ohno Y, Koyama H, Yoshikawa T, et al: N stage disease in patients with non-small cell lung cancer: Efficacy of quantitative and qualitative assessment with STIR turbo spin-echo imaging, diffusion-weighted MR imaging and fluorodeoxyglucose PET/CT. Radiology. 261:605–615. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Wu X, Pertovaara H, Korkola P, et al: Correlations between functional imaging markers derived from PET/CT and diffusion-weighted MRI in diffuse large B-cell lymphoma and follicular lymphoma. PLoS One. 9:e849992014. View Article : Google Scholar : PubMed/NCBI

43 

Thoeny HC, De Keyzer F and King AD: Diffusion-weighted MR imaging in the head and neck. Radiology. 263:19–32. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Ho KC, Lin G, Wang JJ, et al: Correlation of apparent diffusion coefficients measured by 3T diffusion-weighted MRI and SUV from FDG PET/CT in primary cervical cancer. Eur J Nucl Med Mol Imaging. 36:200–208. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Meng Z, Zhang G, Sun H, Tan J, Yu C, Tian W, Li W, Yang Z, Zhu M, He Q, He Q, et al: Differentiation between Graves' disease and painless thyroiditis by diffusion-weighted imaging, thyroid iodine uptake, thyroid scintigraphy and serum parameters. Exp Ther Med 9: 2165-2172, 2015.
APA
Meng, Z., Zhang, G., Sun, H., Tan, J., Yu, C., Tian, W. ... Han, S. (2015). Differentiation between Graves' disease and painless thyroiditis by diffusion-weighted imaging, thyroid iodine uptake, thyroid scintigraphy and serum parameters. Experimental and Therapeutic Medicine, 9, 2165-2172. https://doi.org/10.3892/etm.2015.2430
MLA
Meng, Z., Zhang, G., Sun, H., Tan, J., Yu, C., Tian, W., Li, W., Yang, Z., Zhu, M., He, Q., Zhang, Y., Han, S."Differentiation between Graves' disease and painless thyroiditis by diffusion-weighted imaging, thyroid iodine uptake, thyroid scintigraphy and serum parameters". Experimental and Therapeutic Medicine 9.6 (2015): 2165-2172.
Chicago
Meng, Z., Zhang, G., Sun, H., Tan, J., Yu, C., Tian, W., Li, W., Yang, Z., Zhu, M., He, Q., Zhang, Y., Han, S."Differentiation between Graves' disease and painless thyroiditis by diffusion-weighted imaging, thyroid iodine uptake, thyroid scintigraphy and serum parameters". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2165-2172. https://doi.org/10.3892/etm.2015.2430
Copy and paste a formatted citation
x
Spandidos Publications style
Meng Z, Zhang G, Sun H, Tan J, Yu C, Tian W, Li W, Yang Z, Zhu M, He Q, He Q, et al: Differentiation between Graves' disease and painless thyroiditis by diffusion-weighted imaging, thyroid iodine uptake, thyroid scintigraphy and serum parameters. Exp Ther Med 9: 2165-2172, 2015.
APA
Meng, Z., Zhang, G., Sun, H., Tan, J., Yu, C., Tian, W. ... Han, S. (2015). Differentiation between Graves' disease and painless thyroiditis by diffusion-weighted imaging, thyroid iodine uptake, thyroid scintigraphy and serum parameters. Experimental and Therapeutic Medicine, 9, 2165-2172. https://doi.org/10.3892/etm.2015.2430
MLA
Meng, Z., Zhang, G., Sun, H., Tan, J., Yu, C., Tian, W., Li, W., Yang, Z., Zhu, M., He, Q., Zhang, Y., Han, S."Differentiation between Graves' disease and painless thyroiditis by diffusion-weighted imaging, thyroid iodine uptake, thyroid scintigraphy and serum parameters". Experimental and Therapeutic Medicine 9.6 (2015): 2165-2172.
Chicago
Meng, Z., Zhang, G., Sun, H., Tan, J., Yu, C., Tian, W., Li, W., Yang, Z., Zhu, M., He, Q., Zhang, Y., Han, S."Differentiation between Graves' disease and painless thyroiditis by diffusion-weighted imaging, thyroid iodine uptake, thyroid scintigraphy and serum parameters". Experimental and Therapeutic Medicine 9, no. 6 (2015): 2165-2172. https://doi.org/10.3892/etm.2015.2430
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