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Article

Neutrophil elastase and fetal fibronectin levels as predictors of single-birth prematurity

  • Authors:
    • Fang Ai
    • Gui‑Qing Li
    • Jiang Jiang
    • Xu‑Dong Dong
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics, The First People's Hospital of Yunnan, Kunming, Yunnan 650032, P.R. China
  • Pages: 665-670
    |
    Published online on: May 21, 2015
       https://doi.org/10.3892/etm.2015.2508
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Abstract

The aim of this study was to investigate the predictive values (PVs) of neutrophil elastase (NE) and fetal fibronectin (fFN) in cervical secretions for single‑birth premature delivery. Samples of cervical secretions were obtained from 144 women with high‑risk singleton pregnancies at 20‑34 weeks' gestation and premature Creasy scores of >12 points for NE and fFN level testing, and the PVs of the two indicators for premature birth (PB) were retrospectively analyzed. NE and fFN had high negative PVs (NPVs) for PB; the NPV of NE and fFN for delivery 7 days after detection was significantly higher than the positive PV (P<0.01). In addition, the sensitivity of the combined use of NE and fFN levels for PB prediction was high if both were present, and the PB rate of the double‑positive group was higher than that of the single‑positive group (P<0.01). Clinical intervention could turn the NE and fFN values negative in certain cases; in these cases, the PB rate was significantly lower than that in the sustained‑positive group. In conclusion, NE and fFN in cervical secretions could be used as objective predictors of premature delivery, and their combined application could improve the prediction sensitivity. Effective clinical intervention could then reduce the incidence of PB.
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Copy and paste a formatted citation
Spandidos Publications style
Ai F, Li GQ, Jiang J and Dong XD: Neutrophil elastase and fetal fibronectin levels as predictors of single-birth prematurity. Exp Ther Med 10: 665-670, 2015.
APA
Ai, F., Li, G., Jiang, J., & Dong, X. (2015). Neutrophil elastase and fetal fibronectin levels as predictors of single-birth prematurity. Experimental and Therapeutic Medicine, 10, 665-670. https://doi.org/10.3892/etm.2015.2508
MLA
Ai, F., Li, G., Jiang, J., Dong, X."Neutrophil elastase and fetal fibronectin levels as predictors of single-birth prematurity". Experimental and Therapeutic Medicine 10.2 (2015): 665-670.
Chicago
Ai, F., Li, G., Jiang, J., Dong, X."Neutrophil elastase and fetal fibronectin levels as predictors of single-birth prematurity". Experimental and Therapeutic Medicine 10, no. 2 (2015): 665-670. https://doi.org/10.3892/etm.2015.2508
Copy and paste a formatted citation
x
Spandidos Publications style
Ai F, Li GQ, Jiang J and Dong XD: Neutrophil elastase and fetal fibronectin levels as predictors of single-birth prematurity. Exp Ther Med 10: 665-670, 2015.
APA
Ai, F., Li, G., Jiang, J., & Dong, X. (2015). Neutrophil elastase and fetal fibronectin levels as predictors of single-birth prematurity. Experimental and Therapeutic Medicine, 10, 665-670. https://doi.org/10.3892/etm.2015.2508
MLA
Ai, F., Li, G., Jiang, J., Dong, X."Neutrophil elastase and fetal fibronectin levels as predictors of single-birth prematurity". Experimental and Therapeutic Medicine 10.2 (2015): 665-670.
Chicago
Ai, F., Li, G., Jiang, J., Dong, X."Neutrophil elastase and fetal fibronectin levels as predictors of single-birth prematurity". Experimental and Therapeutic Medicine 10, no. 2 (2015): 665-670. https://doi.org/10.3892/etm.2015.2508
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