Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases

Li,Ming; Gao,Wenjuan; Ma,Jingjing; Zhu,Yun; Li,Xingfu

doi:10.3892/etm.2015.2510

August-2015 Volume 10 Issue 2

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August-2015 Volume 10 Issue 2

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Article

Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases

Authors:
- Ming Li
- Wenjuan Gao
- Jingjing Ma
- Yun Zhu
- Xingfu Li
View Affiliations / Copyright

Affiliations: Department of Rheumatism and Immunity, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Ultrasound, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Rheumatism and Immunity, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
Pages: 689-692
|
Published online on: May 21, 2015

https://doi.org/10.3892/etm.2015.2510
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Abstract

The oxidative-antioxidative status is closely associated with the progression of systemic lupus erythematosus (SLE), and oxidative stress is customarily found in patients with SLE. N‑acetylcysteine (NAC), a typical antioxidant, is reliable and often applied for clinical treatment. Lupus nephritis (LN) is a kidney disorder associated with SLE, but the treatment of LN with antioxidants is rarely documented. The present report describes two cases of early‑stage LN that were orally treated with 1,200 mg NAC in addition to the standard therapy with hydroxychloroquine and calcitriol. Following the NAC administration, the glutathione level largely increased while the level of the lipid peroxidation biomarker 8-iso-prostaglandin F2α declined in both cases. In addition, the routine blood counts, 24‑h urine protein, erythrocyte sedimentation rate and the SLE disease activity index were markedly improved. In conclusion, the present report of two cases has shown that NAC, as an antioxidant, may exert a beneficial effect to modulate the oxidative status in LN; however, the underlying mechanisms require further investigation.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases

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