Anti-neutrophil cytoplasmic antibody-negative microscopic polyangiitis: A case report and literature review

Wang,Ran; Yang,Xiao‑Chun; Zhou,Si‑Jing; Sun,Geng‑Yun

doi:10.3892/etm.2015.2523

August-2015 Volume 10 Issue 2

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August-2015 Volume 10 Issue 2

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Case Report

Anti-neutrophil cytoplasmic antibody-negative microscopic polyangiitis: A case report and literature review

Authors:
- Ran Wang
- Xiao‑Chun Yang
- Si‑Jing Zhou
- Geng‑Yun Sun
View Affiliations / Copyright

Affiliations: Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Hefei Prevention and Treatment Center for Occupational Diseases, Hefei, Anhui 230022, P.R. China
Pages: 749-752
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Published online on: May 26, 2015

https://doi.org/10.3892/etm.2015.2523
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Abstract

The aim of this study was to investigate the clinical characteristics, diagnosis and treatment of anti-neutrophil cytoplasmic antibody (ANCA)-negative microscopic polyangiitis (MPA). We described the case of a patient with ANCA‑negative MPA and conducted analyses and a review of the relevant literature. Based on the collected data, the epidemiology, diagnosis and treatment of ANCA‑negative MPA were discussed. The patient, a 69‑year‑old male, was initially diagnosed with pneumonia and interstitial lung disease (ILD) based on his clinical symptoms. The patient was ANCA‑negative. The follow‑up and consultations with the relevant departments after the ANCA testing led to a diagnosis of MPA being considered. The administration of glucocorticoids and immunosuppressant drugs was found to improve the symptoms of the patient. The clinical symptoms of MPA are unspecific. The majority of MPA cases are ANCA‑positive, but misdiagnosis should be considered as a possibility in ANCA‑negative cases. When patients are suspected to have MPA, therefore, ANCA tests should be immediately performed. Test results should be analyzed for the early diagnosis of MPA in order to enable the provision of immediate treatment, improve patient prognosis and reduce mortality rate.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Anti-neutrophil cytoplasmic antibody-negative microscopic polyangiitis: A case report and literature review

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