A rare case of focal nesidioblastosis causing adult-onset hypoglycemia

Qin,Hanjiao; Li,Zhuo; Qu,Limei; Liu,Yujia; Gao,Ying; Li,Fei; Wang,Guixia

doi:10.3892/etm.2015.2541

August-2015 Volume 10 Issue 2

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August-2015 Volume 10 Issue 2

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Article

A rare case of focal nesidioblastosis causing adult-onset hypoglycemia

Authors:
- Hanjiao Qin
- Zhuo Li
- Limei Qu
- Yujia Liu
- Ying Gao
- Fei Li
- Guixia Wang
View Affiliations / Copyright

Affiliations: Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Pathology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
Pages: 723-726
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Published online on: June 3, 2015

https://doi.org/10.3892/etm.2015.2541
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Abstract

Nesidioblastosis is a major cause of persistent hyperinsulinemic hypoglycemia of infancy and is caused by hypertrophy of the pancreatic endocrine islands. The disease can be categorized histologically into diffuse and focal forms. The condition rarely occurs in adults and only one adult case of suspected, but not histologically confirmed, focal nesidioblastosis has been reported. The present study describes the case of a 62‑year‑old man suffering from symptomatic hypoglycemia for 3 years and exhibiting a nodule in the pancreatic tail. Pathological evaluation following surgical enucleation of the pancreatic body and tail revealed focal nesidioblastosis. The hypoglycemic symptoms of the patient disappeared postoperatively. To the best of our knowledge, this is the first histologically‑confirmed case of focal adult nesidioblastosis, suggesting that the possibility of nesidioblastosis should be taken into account in adult patients with persistent hypoglycemia.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

A rare case of focal nesidioblastosis causing adult-onset hypoglycemia

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