Cytotoxicity of the saponin TTB2 on Ewing sarcoma cells

  • Authors:
    • Wenfeng Huang
    • Kun Zou
  • View Affiliations

  • Published online on: June 3, 2015     https://doi.org/10.3892/etm.2015.2544
  • Pages: 625-628
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Abstract

The steroidal saponin TTB2 can be isolated from the n-BuOH extracts of Trillium tschonoskii Maxim. The aim of the present study was to observe whether this saponin exerted any cytotoxic effects on malignant sarcoma cells, and to further investigate the possible underlying molecular mechanisms. The cell viability, cell cycle arrest and phosphorylation of certain important signal molecules in the sarcoma cell line were investigated. It was found that TTB2 inhibited the growth of the Ewing sarcoma cell line and arrested cells in the G2/M and S phases of the cell cycle in a dose‑ and time‑dependent manner. Furthermore, the phosphorylation of extracellular signal‑regulated kinase was inhibited by TTB2. In conclusion, the results showed that the saponin TTB2 isolated from T. tschonoskii Maxim exerts anticancer effects and may be a potential candidate for the development of anticancer drugs for use in the treatment of cancer.
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August-2015
Volume 10 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Huang W and Huang W: Cytotoxicity of the saponin TTB2 on Ewing sarcoma cells. Exp Ther Med 10: 625-628, 2015
APA
Huang, W., & Huang, W. (2015). Cytotoxicity of the saponin TTB2 on Ewing sarcoma cells. Experimental and Therapeutic Medicine, 10, 625-628. https://doi.org/10.3892/etm.2015.2544
MLA
Huang, W., Zou, K."Cytotoxicity of the saponin TTB2 on Ewing sarcoma cells". Experimental and Therapeutic Medicine 10.2 (2015): 625-628.
Chicago
Huang, W., Zou, K."Cytotoxicity of the saponin TTB2 on Ewing sarcoma cells". Experimental and Therapeutic Medicine 10, no. 2 (2015): 625-628. https://doi.org/10.3892/etm.2015.2544