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Article

Expression and significance of annexin A2 in patients with gastric adenocarcinoma and the association with E‑cadherin

  • Authors:
    • Yuehua Han
    • Jun Ye
    • Ying Dong
    • Zhipeng Xu
    • Qin Du
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China, Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China
  • Pages: 549-554
    |
    Published online on: June 10, 2015
       https://doi.org/10.3892/etm.2015.2565
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Abstract

Annexin A2 is a calcium‑dependent phospholipid‑binding protein, involved in invasion, angiogenesis and migration in cancer cells. The aims of the present study were to evaluate the expression levels of annexin A2 and E‑cadherin in gastric adenocarcinoma (GAC), and to investigate the association between the expression of annexin A2 and that of E‑cadherin and Ki67, in addition to various clinicopathological factors. This study included 126 patients that were histopathologically diagnosed with GAC. Tissue samples were acquired by surgical resection, and annexin A2 mRNA expression levels were determined using reverse transcription‑quantitative polymerase chain reaction. Annexin A2, E‑cadherin and Ki67 protein expression levels were detected using western blot analysis and/or immunohistochemical staining. The expression of annexin A2 mRNA and protein was significantly upregulated in the GAC tissues. Annexin A2 expression was detected in 52/126 cases (41.3%) of gastric cancer (GC), and correlations were identified between annexin A2 expression and Tumor, Node, Metastasis (TNM) stage (P=0.002), lymph node metastasis (P=0.016) and distal metastasis (P=0.005). The positive expression rates of E‑cadherin and Ki67 in the tumor tissue of patients with GAC were 27.8% (35/126) and 56.2% (71/126), respectively. A negative correlation was observed between the expression of annexin A2 and E‑cadherin (P<0.001). No significant association was detected between the expression levels of annexin A2 and Ki67 (P=0.801). In conclusion, upregulated annexin A2 expression was associated with lymph node metastasis, distal metastasis, advanced TNM stage and E‑cadherin expression in patients with GAC. The association between the expression of annexin A2 and that of E‑cadherin may indicate an underlying mechanism by which annexin A2 contributes to the metastasis in GC, and thus annexin A2 may represent a potential target for the treatment of GAC.
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View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:692011. View Article : Google Scholar : PubMed/NCBI

2 

Zhang YZ, Zhang LH, Gao Y, Li CH, Jia SQ, Liu N, Cheng F, Niu DY, Cho WC, Ji JF and Zeng CQ: Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling. World J Gastroenterol. 17:1710–1717. 2010. View Article : Google Scholar

3 

Zhai H, Acharya S, Gravanis I, Mehmood S, Seidman RJ, Shroyer KR, Hajjar KA and Tsirka SE: Annexin A2 promotes glioma cell invasion and tumor progression. J Neurosci. 31:14346–14360. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Zheng L, Foley K, Huang L, Leubner A, Mo G, Olino K, Edil BH, Mizuma M, Sharma R, Le DT, et al: Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer. PLoS One. 6:e193902011. View Article : Google Scholar : PubMed/NCBI

5 

Zhang X, Liu S, Guo C, Zong J and Sun MZ: The association of annexin A2 and cancers. Clin Transl Oncol. 14:634–640. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Jacomo RH, Santana-Lemos BA, Lima AS, Assis PA, Lange AP, Figueiredo-Pontes LL, Oliveira LO, Bassi SC, Benício MT, Baggio MS, et al: Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia. Blood. 120:207–213. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Leal MF, Calcagno DQ, Chung J, de Freitas VM, Demachki S, Assumpção PP, Chammas R, Burbano RR and Smith MC: Deregulated expression of annexin-A2 and galectin-3 is associated with metastasis in gastric cancer patients. Clin Exp Med. Jul 18–2014.(Epub ahead of print). View Article : Google Scholar

8 

Deng S, Wang J, Hou L, Hou L, Li J, Chen G, Jing B, Zhang X and Yang Z: Annexin A1, A2, A4 and A5 play important roles in breast cancer, pancreatic cancer and laryngeal carcinoma, alone and/or synergistically. Oncol Lett. 5:1072013.PubMed/NCBI

9 

Yang T, Peng H, Wang J, Yang J, Nice EC, Xie K and Huang C: Prognostic and diagnostic significance of annexin A2 in colorectal cancer. Colorectal Dis. 15:e373–e381. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Rodrigo JP, Lequerica-Fernandez P, Rosado P, Rosado P, Allonca E, García-Pedrero JM and de Vicente JC: Clinical significance of annexin A2 downregulation in oral squamous cell carcinoma. Head Neck. 33:1708–1714. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Rodrigo JP, Garcia-Pedrero JM, Llorente JL, Fresno MF, Allonca E, Suarez C and Hermsen M: Down-regulation of annexin A1 and A2 protein expression in intestinal-type sinonasal adenocarcinomas. Hum Pathol. 42:88–94. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Yee DS, Narula N, Ramzy I, Boker J, Ahlering TE, Skarecky DW and Ornstein DK: Reduced annexin II protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. Arch Pathol Lab Med. 131:902–908. 2007.PubMed/NCBI

13 

Wu A, Jia Y, Dong B, Tang L, Liu Y, Du H, Yuan P, Dong P and Ji J: Apoptosis and KI67 index correlate with preoperative chemotherapy efficacy and better predict the survival of gastric cancer patients with combined therapy. Cancer Chemother Pharmacol. 73:885–893. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Zhong XY, Zhang LH, Jia SQ, Shi T, Niu ZJ, Du H, Zhang GG, Hu Y, Lu AP, Li JY, et al: Positive association of up-regulated Cripto-1 and down-regulated E-cadherin with tumour progression and poor prognosis in gastric cancer. Histopathology. 52:560–568. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Ahn HS, Kim SH, Kodera Y and Yang HK: Gastric cancer staging with radiologic imaging modalities and UICC staging system. Dig Surg. 30:142–149. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Seidah NG, Poirier S, Denis M, et al: Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. PLoS One. 7:e418652012. View Article : Google Scholar : PubMed/NCBI

17 

Qiu MZ, Li ZH, Zhou ZW, Parker R, Miao B, Mapelli C, Prat A, Wassef H, Davignon J, Hajjar KA, et al: Detection of carcinoembryonic antigen messenger RNA in blood using quantitative real-time reverse transcriptase-polymerase chain reaction to predict recurrence of gastric adenocarcinoma. J Transl Med. 8:1072010. View Article : Google Scholar : PubMed/NCBI

18 

Hoffmann AC, Goekkurt E, Danenberg PV, Lehmann S, Ehninger G, Aust DE and Stoehlmacher-Williams J: EGFR, FLT1 and heparanase as markers identifying patients at risk of short survival in cholangiocarcinoma. PLoS One. 8:e641862013. View Article : Google Scholar : PubMed/NCBI

19 

Zhang Q, Ye Z, Yang Q, et al: Upregulated expression of annexin II is a prognostic marker for patients with gastric cancer. World J Surg Oncol. 10:1032012. View Article : Google Scholar : PubMed/NCBI

20 

Yu XW, Xu Q, Xu Y, He X, Wang H and Zhao Z: Expression of the E-cadherin/beta-catenin/tcf-4 pathway in gastric diseases with relation to Helicobacter pylori infection: Clinical and pathological implications. Asian Pac J Cancer Prev. 15:215–220. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Rescher U and Gerke V: Annexins - unique membrane binding proteins with diverse functions. J Cell Sci. 117:2631–2639. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Mai J, Waisman DM and Sloane BF: Cell surface complex of cathepsin B/annexin II tetramer in malignant progression. Biochim Biophys Acta. 1477:215–230. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Sharma MC and Sharma M: The role of annexin II in angiogenesis and tumor progression: A potential therapeutic target. Curr Pharm Des. 13:3568–3575. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Gao M, Li W, Wang H and Wang G: The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues. Diagn Pathol. 8:2052013. View Article : Google Scholar : PubMed/NCBI

25 

Luo CH, Liu QQ, Zhang PF, Li MY, Chen ZC and Liu YF: Prognostic significance of annexin II expression in non-small cell lung cancer. Clin Transl Oncol. 15:938–946. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Deng S, Jing B, Xing T, Hou L and Yang Z: Overexpression of annexin A2 is associated with abnormal ubiquitination in breast cancer. Genomics Proteomics Bioinformatics. 10:153–157. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Duncan R, Carpenter B, Main LC, Telfer C and Murray GI: Characterisation and protein expression profiling of annexins in colorectal cancer. Br J Cancer. 98:4262008. View Article : Google Scholar : PubMed/NCBI

28 

Swisher JF, Khatri U and Feldman GM: Annexin A2 is a soluble mediator of macrophage activation. J Leukoc Biol. 82:1174–1184. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Madureira PA, O'Connell PA, Surette AP, Miller VA and Waisman DM: The biochemistry and regulation of S100A10: A multifunctional plasminogen receptor involved in oncogenesis. J Biomed Biotechnol. 2012:3536872012. View Article : Google Scholar : PubMed/NCBI

30 

He KL, Sui G, Xiong H, Broekman MJ, Huang B, Marcus AJ and Hajjar KA: Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2. J Biol Chem. 286:15428–15439. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Han Y, Ye J, Dong Y, Xu Z and Du Q: Expression and significance of annexin A2 in patients with gastric adenocarcinoma and the association with E‑cadherin. Exp Ther Med 10: 549-554, 2015.
APA
Han, Y., Ye, J., Dong, Y., Xu, Z., & Du, Q. (2015). Expression and significance of annexin A2 in patients with gastric adenocarcinoma and the association with E‑cadherin. Experimental and Therapeutic Medicine, 10, 549-554. https://doi.org/10.3892/etm.2015.2565
MLA
Han, Y., Ye, J., Dong, Y., Xu, Z., Du, Q."Expression and significance of annexin A2 in patients with gastric adenocarcinoma and the association with E‑cadherin". Experimental and Therapeutic Medicine 10.2 (2015): 549-554.
Chicago
Han, Y., Ye, J., Dong, Y., Xu, Z., Du, Q."Expression and significance of annexin A2 in patients with gastric adenocarcinoma and the association with E‑cadherin". Experimental and Therapeutic Medicine 10, no. 2 (2015): 549-554. https://doi.org/10.3892/etm.2015.2565
Copy and paste a formatted citation
x
Spandidos Publications style
Han Y, Ye J, Dong Y, Xu Z and Du Q: Expression and significance of annexin A2 in patients with gastric adenocarcinoma and the association with E‑cadherin. Exp Ther Med 10: 549-554, 2015.
APA
Han, Y., Ye, J., Dong, Y., Xu, Z., & Du, Q. (2015). Expression and significance of annexin A2 in patients with gastric adenocarcinoma and the association with E‑cadherin. Experimental and Therapeutic Medicine, 10, 549-554. https://doi.org/10.3892/etm.2015.2565
MLA
Han, Y., Ye, J., Dong, Y., Xu, Z., Du, Q."Expression and significance of annexin A2 in patients with gastric adenocarcinoma and the association with E‑cadherin". Experimental and Therapeutic Medicine 10.2 (2015): 549-554.
Chicago
Han, Y., Ye, J., Dong, Y., Xu, Z., Du, Q."Expression and significance of annexin A2 in patients with gastric adenocarcinoma and the association with E‑cadherin". Experimental and Therapeutic Medicine 10, no. 2 (2015): 549-554. https://doi.org/10.3892/etm.2015.2565
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