Cutaneous Rosai-Dorfman disease in a middle-aged man: A case report

Yang,Min; Chang,Jianmin

doi:10.3892/etm.2015.2580

September-2015 Volume 10 Issue 3

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September-2015 Volume 10 Issue 3

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Case Report

Cutaneous Rosai-Dorfman disease in a middle-aged man: A case report

Authors:
- Min Yang
- Jianmin Chang
View Affiliations / Copyright

Affiliations: Department of Dermatology, Beijing Hospital, Beijing 100730, P.R. China
Pages: 1199-1201
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Published online on: June 18, 2015

https://doi.org/10.3892/etm.2015.2580
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Abstract

The present study describes a case of cutaneous Rosai-Dorfman disease (CRDD). The clinical manifestations and therapeutic options of CRDD vary, and the etiology of the disease is still unknown. The clinical manifestations include single or multiple yellow‑red to brown or purple papules, nodules and/or plaques, with the face being the most frequently affected site. A 52‑year‑old man presented with an 8‑month history of multiple lesions on his face. Physical examination revealed a number of yellow‑red papules and nodules, the majority of which had coalesced into plaques. The histological finding from a red papule showed a dense, dermal infiltrate, which was predominantly composed of large histiocytes, strongly positive for S‑100 and cluster of differentiation (CD)68 but negative for CD1a, mixed with aggregates of lymphocytes and scattered plasma cells and eosinophils. The patient showed only a marginal improvement with a month of oral, low-dose prednisone.

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1	Rosai J and Dorfman RF: Sinus histiocytosis with massive lymphadenopathy: A newly recognized benign clinicopathologic entity. Arch Pathol. 87:63–70. 1969.PubMed/NCBI
2	Foucar E, Rosai J and Dorfman R: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): Review of the entity. Semin Diagn Pathol. 7:19–73. 1990.PubMed/NCBI
3	Pitamber HV and Grayson W: Five cases of cutaneous Rosai-Dorfman disease. Clin Exp Dermatol. 28:17–21. 2003. View Article : Google Scholar : PubMed/NCBI
4	Lu CI, Kuo TT, Wong WR and Hong HS: Clinical and histopathological spectrum of cutanous Rosai-Dorfman disease in Taiwan. J Am Acad Dermatol. 51:931–939. 2004. View Article : Google Scholar : PubMed/NCBI
5	Sun NZ, Galvin J and Cooper KD: Cutaneous Rosai-Dorfman disease successfully treated with low-dose methotrexate. JAMA Dermatol. 150:787–788. 2014. View Article : Google Scholar : PubMed/NCBI
6	Brenn T, Calonje E, Granter SR, et al: Cutaneous Rosai-Dorfman disease is a distinct clinical entity. Am J Dermatopathol. 24:385–391. 2002. View Article : Google Scholar : PubMed/NCBI
7	Cangelosi JJ, Prieto VG and Ivan D: Cutaneous Rosai-Dorfman disease with increased number of eosinophils: Coincidence or histologic variant? Arch Pathol Lab Med. 135:1597–1600. 2011. View Article : Google Scholar : PubMed/NCBI
8	Molina-Garrido MJ and Guillén-Ponce C: Extranodal Rosai-Dorfman disease with cutaneous and periodontal involvement: A rare presentation. Case Rep Oncol. 4:96–100. 2011. View Article : Google Scholar : PubMed/NCBI
9	Bassis AV, Fairley JA, Ameln RT and Swick BL: Cutaneous Rosai-Dorfman disease following pneumococcal vaccination. J Am Acad Dermatol. 65:890–892. 2011. View Article : Google Scholar : PubMed/NCBI
10	Bunick CG, Leffell D, Bosenberg M, et al: Cutaneous Rosai-Dorfman disease of the right ear responsive to radiotherapy. J Am Acad Dermatol. 67:e225–e226. 2012. View Article : Google Scholar : PubMed/NCBI
11	Fumerton R, Ball N and Zhou Y: Refractory cutaneous Rosai-Dorfman disease responsive to cryotherapy. Cutis. 87:296–299. 2011.PubMed/NCBI
12	Fening K, Bechtel M, Peters S, et al: Cutaneous Rosai-Dorfman disease persisting after surgical excision: Report of a case treated with acitretin. J Clin Aesthet Dermatol. 3:34–36. 2010.PubMed/NCBI
13	Chang HS, Son SJ, Cho KH and Lee JH: Therapeutic challenge of dapsone in the treatment of purely cutaneous Rosai-Dorfman disease. Clin Exp Dermatol. 36:420–422. 2011. View Article : Google Scholar : PubMed/NCBI
14	Tjiu JW, Hsiao CH and Tsai TF: Cutaneous Rosai-Dorfman disease: Remission with thalidomide treatment. Br J Dermatol. 148:1060–1061. 2003. View Article : Google Scholar : PubMed/NCBI
15	Oka M, Kamo T, Goto N, et al: Successful treatment of Rosai-Dorfman disease with low-dose oral corticosteroid. J Dermatol. 36:237–240. 2009. View Article : Google Scholar : PubMed/NCBI
16	Nadal M, Kervarrec T, Machet MC, et al: Cutaneous Rosai-Dorfman disease located on the breast: Rapid effectiveness of methotrexate after failure of topical corticosteroids, acitretin and thalidomide. Acta Derm Venereol. Jan 29–2015.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI
17	Gebhardt C, Averbeck M, Paasch U, et al: A case of cutaneous Rosai-Dorfman disease refractory to imatinib therapy. Arch Dermatol. 145:571–574. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cutaneous Rosai-Dorfman disease in a middle-aged man: A case report

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