Cutaneous Rosai-Dorfman disease in a middle-aged man: A case report

Yang,Min; Chang,Jianmin

doi:10.3892/etm.2015.2580

Cutaneous Rosai-Dorfman disease in a middle-aged man: A case report

Authors:
- Min Yang
- Jianmin Chang
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Affiliations: Department of Dermatology, Beijing Hospital, Beijing 100730, P.R. China
Published online on: June 18, 2015 https://doi.org/10.3892/etm.2015.2580
Pages: 1199-1201

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Abstract

The present study describes a case of cutaneous Rosai-Dorfman disease (CRDD). The clinical manifestations and therapeutic options of CRDD vary, and the etiology of the disease is still unknown. The clinical manifestations include single or multiple yellow‑red to brown or purple papules, nodules and/or plaques, with the face being the most frequently affected site. A 52‑year‑old man presented with an 8‑month history of multiple lesions on his face. Physical examination revealed a number of yellow‑red papules and nodules, the majority of which had coalesced into plaques. The histological finding from a red papule showed a dense, dermal infiltrate, which was predominantly composed of large histiocytes, strongly positive for S‑100 and cluster of differentiation (CD)68 but negative for CD1a, mixed with aggregates of lymphocytes and scattered plasma cells and eosinophils. The patient showed only a marginal improvement with a month of oral, low-dose prednisone.

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