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Case Report

Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature

  • Authors:
    • Hongzai Guan
    • Jing Liu
    • Xiaofang Guo
    • Chunmei Wu
    • Huawei Yu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Hematology, Medical College of Qingdao University, Qingdao, Shandong 266071, P.R. China, Clinical Laboratory of the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Clinical Laboratory of No. 401 Hospital, PLA, Qingdao, Shandong 266071, P.R. China
  • Pages: 1009-1012
    |
    Published online on: June 18, 2015
       https://doi.org/10.3892/etm.2015.2583
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Abstract

Acute promyelocytic leukemia (APL) with variant translocations is rare. The patient of the present case report, a 2‑year‑old male with a microgranular variant of APL carrying der(17) ins(17;15) translocation, exhibited fever and epistaxis. The complete blood count showed marked leukocytosis with 72% atypical promyelocytes, anemia and thrombocytopenia. Conventional cytogenetic analysis of the bone marrow cells revealed a karyotype of 47, XY, add(3)(q29), ‑7, ins(17;15)(q12;q14q22),+21,+mar. The promyelocytic leukemia/retinoic acid receptor α (PML/RARα) rearrangement and insertion were confirmed by fluorescence in situ hybridization. The PML/RARα transcripts were not detected by the reverse transcription polymerase chain reaction, and the patient was diagnosed with microgranular variant M3 APL. The patient achieved remission after a 30‑day treatment and was still in remission during a recent follow‑up. The present findings suggest that the ins(17;15) variant in APL may not be associated with an unfavorable prognosis. In summary, we reported an extremely rare case of APL with der(17) ins(17;15) abnormality in a pediatric patient and reviewed the literature.
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Copy and paste a formatted citation
Spandidos Publications style
Guan H, Liu J, Guo X, Wu C and Yu H: Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature. Exp Ther Med 10: 1009-1012, 2015.
APA
Guan, H., Liu, J., Guo, X., Wu, C., & Yu, H. (2015). Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature. Experimental and Therapeutic Medicine, 10, 1009-1012. https://doi.org/10.3892/etm.2015.2583
MLA
Guan, H., Liu, J., Guo, X., Wu, C., Yu, H."Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature". Experimental and Therapeutic Medicine 10.3 (2015): 1009-1012.
Chicago
Guan, H., Liu, J., Guo, X., Wu, C., Yu, H."Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature". Experimental and Therapeutic Medicine 10, no. 3 (2015): 1009-1012. https://doi.org/10.3892/etm.2015.2583
Copy and paste a formatted citation
x
Spandidos Publications style
Guan H, Liu J, Guo X, Wu C and Yu H: Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature. Exp Ther Med 10: 1009-1012, 2015.
APA
Guan, H., Liu, J., Guo, X., Wu, C., & Yu, H. (2015). Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature. Experimental and Therapeutic Medicine, 10, 1009-1012. https://doi.org/10.3892/etm.2015.2583
MLA
Guan, H., Liu, J., Guo, X., Wu, C., Yu, H."Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature". Experimental and Therapeutic Medicine 10.3 (2015): 1009-1012.
Chicago
Guan, H., Liu, J., Guo, X., Wu, C., Yu, H."Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature". Experimental and Therapeutic Medicine 10, no. 3 (2015): 1009-1012. https://doi.org/10.3892/etm.2015.2583
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