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Article

Therapeutic effect of intravitreal injections of ranibizumab for the treatment of macular choroidal neovascularization caused by pathological myopia

  • Authors:
    • Leibing Ji
    • Wenjuan Lv
    • Yun Xiao
    • Zhenghua Xu
    • Xiaoling Zhang
    • Wei Zhang
  • View Affiliations / Copyright

    Affiliations: PLA Ophthalmic Center, No. 474 Hospital of the Chinese PLA, Urumqi, Xinjiang Uyghur Autonomous Region 830011, P.R. China, The Graduate School, Shihezi University, Shihezi, Xinjiang 832000, P.R. China
  • Pages: 1121-1126
    |
    Published online on: July 7, 2015
       https://doi.org/10.3892/etm.2015.2625
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Abstract

The aim of the present study was to evaluate the clinical efficacy and safety of intravitreal ranibizumab injections for the treatment of macular choroidal neovascularization (CNV) caused by pathological myopia. Between one and four intravitreal injections of ranibizumab were administered to 61 eyes from 61 patients who were diagnosed with macular CNV caused by pathological myopia. Following injection, the best‑corrected visual acuity (BCVA), central macular thickness (CMT) and fundus fluorescein angiography (FFA) findings were evaluated monthly for a period of 6 months. Among the 61 eyes, 10 eyes received one injection, 44 received two injections, six received three injections and one received four injections (average, 1.97 injections). The BCVA was 0.02±0.01 prior to treatment and 0.30±0.03 subsequent to treatment, and this difference was statistically significant (P<0.01). The CMT was reduced by an average of 45.1 µm. Regarding the FFA results, 56 eyes had no CNV fluorescence leakage and five eyes had CNV fluorescence leakage following treatment; however, the intensity of CNV fluorescence leakage in the five eyes following treatment was lower than that prior to treatment. As a treatment for pathological myopia‑induced macular CNV, intravitreal injections of ranibizumab may improve eyesight as well as the macular retinal tissue structure; thus, this is a safe and effective treatment method.
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1 

Silva R: Myopic maculopathy: A review. Ophthalmologica. 228:197–213. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Sawada A, Tomidokoro A, Araie M, Iwase A and Yamamoto T: Tajimi Study Group: Refractive errors in an elderly Japanese population: The Tajimi study. Ophthalmology. 115:363–370. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Cheng CY, Hsu WM, Liu JH, Tsai SY and Chou P: Refractive errors in an elderly Chinese population in Taiwan: The Shihpai Eye Study. Invest Ophthalmol Vis Sci. 44:4630–4638. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Rosenfeld PJ, Brown DM, Heier JS, et al: MARINA Study Group: Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 355:1419–1431. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Pece A, Vadalà M, Isola V and Matranga D: Photodynamic therapy with verteporfin for juxtafoveal choroidal neovascularizzation in pathologic myopia: A long-term follow-up study. Am J Ophthalmol. 143:449–454. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Martin DF, Maguire MG, Ying GS, Grunwald JE, Fine SL and Jaffe GJ: CATT Research Group: Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 364:1897–1908. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Gharbiya M, Allievi F, Mazzeo L and Gabrieli CB: Intravitreal bevacizumab treatment for choroidal neovascularization in pathologic myopia: 12-month results. Am J Ophthalmol. 147:84–93, e1. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Vadalà M, Pece A, Cipolla S, et al: Is ranibizumab effective in stopping the loss of vision for choroidal neovascularisation in pathologic myopia? A long-term follow-up study. Br J Ophthalmol. 95:657–661. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Otsuka K, Imai H, Shimoyama T, Nagai T, Honda S and Azumi A: Recurrence of macular hole retinal detachment after intravitreal ranibizumab injection for the treatment of choroidal neovascularization from the remaining macular hole edge. Case Rep Ophthalmol. 3:424–427. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Lorenzo D, Arias L, Alcubierre R, et al: Intravitreal ranibizumab for choroidal neovascularization secondary to pathological myopia: 12-month follow-up. Ophthalmologica. 226:103–109. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Yoshida T, Ohno-Matsui K, Yasuzumi K, et al: Myopic choroidal neovascularization: A 10-year follow-up. Ophthalmology. 110:1297–1305. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Hayashi K, Shimada N, Moriyama M, Hayashi W, Tokoro T and Ohno-Matsui K: Two-year outcomes of intravitreal bevacizumab for choroidal neovascularization in Japanese patients with pathologic myopia. Retina. 32:687–695. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Wakabayashi T, Ikuno Y and Gomi F: Different dosing of intravitreal bevacizumab for choroidal neovascularization because of pathologic myopia. Retina. 31:880–886. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Mateo C, Moreno J, Rosales G, et al: Two-year results of macular translocation with scleral infolding in myopic choroidal neovascularisation. Semin Ophthalmol. 19:29–42. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Ladas ID, Moschos MM, Rouvas AA, Karagiannis DA and Kokolakis SN: Lacquer crack formation after photodynamic therapy. Eur J Ophthalmol. 13:729–733. 2003.PubMed/NCBI

16 

Ferrara N, Damico L, Shams N, Lowman H and Kim R: Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina. 26:859–870. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Chen Y, Wiesmann C, Fuh G, et al: Selection and analysis of an optimized anti-VEGF antibody: Crystal structure of an affinity-matured Fab in complex with antigen. J Mol Biol. 293:865–881. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Krzystolik MG, Afshari MA, Adamis AP, et al: Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol. 120:338–346. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Figurska M and Stankiewicz A: Anti-VEGF therapy in the treatment of myopic macular choroidal neovascularization - case report. Klin Oczna. 110:387–391. 2008.(In Polish). PubMed/NCBI

20 

Ng DS, Kwok AK and Chan CW: Anti-vascular endothelial growth factor for myopic choroidal neovascularization. Clin Experiment Ophthalmol. 40:e98–e110. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Wu TT and Kung YH: The 12-month outcome of three consecutive monthly intravitreal injections of ranibizumab for myopic choroidal neovascularization. J Ocul Pharmacol Ther. 28:129–133. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Lai TY, Chan WM, Liu DT and Lam DS: Intravitreal ranibizumab for the primary treatment of choroidal neovascularization secondary to pathologic myopia. Retina. 29:750–756. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Calvo-Gonzalez C, Reche-Frutos J, Donate J, Fernandez-Perez C and Garcia-Feijoo J: Intravitreal ranibizumab for myopic choroidal neovascularization: Factors predictive of visual outcome and need for retreatment. Am J Ophthalmol. 151:529–534. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Neelam K, Cheung CM, Ohno-Matsui K, Lai TY and Wong TY: Choroidal neovascularization in pathological myopia. Prog Retin Eye Res. 31:495–525. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ji L, Lv W, Xiao Y, Xu Z, Zhang X and Zhang W: Therapeutic effect of intravitreal injections of ranibizumab for the treatment of macular choroidal neovascularization caused by pathological myopia. Exp Ther Med 10: 1121-1126, 2015.
APA
Ji, L., Lv, W., Xiao, Y., Xu, Z., Zhang, X., & Zhang, W. (2015). Therapeutic effect of intravitreal injections of ranibizumab for the treatment of macular choroidal neovascularization caused by pathological myopia. Experimental and Therapeutic Medicine, 10, 1121-1126. https://doi.org/10.3892/etm.2015.2625
MLA
Ji, L., Lv, W., Xiao, Y., Xu, Z., Zhang, X., Zhang, W."Therapeutic effect of intravitreal injections of ranibizumab for the treatment of macular choroidal neovascularization caused by pathological myopia". Experimental and Therapeutic Medicine 10.3 (2015): 1121-1126.
Chicago
Ji, L., Lv, W., Xiao, Y., Xu, Z., Zhang, X., Zhang, W."Therapeutic effect of intravitreal injections of ranibizumab for the treatment of macular choroidal neovascularization caused by pathological myopia". Experimental and Therapeutic Medicine 10, no. 3 (2015): 1121-1126. https://doi.org/10.3892/etm.2015.2625
Copy and paste a formatted citation
x
Spandidos Publications style
Ji L, Lv W, Xiao Y, Xu Z, Zhang X and Zhang W: Therapeutic effect of intravitreal injections of ranibizumab for the treatment of macular choroidal neovascularization caused by pathological myopia. Exp Ther Med 10: 1121-1126, 2015.
APA
Ji, L., Lv, W., Xiao, Y., Xu, Z., Zhang, X., & Zhang, W. (2015). Therapeutic effect of intravitreal injections of ranibizumab for the treatment of macular choroidal neovascularization caused by pathological myopia. Experimental and Therapeutic Medicine, 10, 1121-1126. https://doi.org/10.3892/etm.2015.2625
MLA
Ji, L., Lv, W., Xiao, Y., Xu, Z., Zhang, X., Zhang, W."Therapeutic effect of intravitreal injections of ranibizumab for the treatment of macular choroidal neovascularization caused by pathological myopia". Experimental and Therapeutic Medicine 10.3 (2015): 1121-1126.
Chicago
Ji, L., Lv, W., Xiao, Y., Xu, Z., Zhang, X., Zhang, W."Therapeutic effect of intravitreal injections of ranibizumab for the treatment of macular choroidal neovascularization caused by pathological myopia". Experimental and Therapeutic Medicine 10, no. 3 (2015): 1121-1126. https://doi.org/10.3892/etm.2015.2625
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