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Clinical value of real‑time elastography quantitative parameters in evaluating the stage of liver fibrosis and cirrhosis

  • Authors:
    • Lan Ge
    • Baomin Shi
    • Ye Song
    • Yuan Li
    • Shuo Wang
    • Xiuyan Wang

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  • Published online on: July 7, 2015     https://doi.org/10.3892/etm.2015.2628
  • Pages: 983-990
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Abstract

The aim of the present study was to assess the value of real‑time elastography (RTE) quantitative parameters, namely the liver fibrosis (LF) index and the ratio of blue area (%AREA), in evaluating the stage of liver fibrosis. RTE quantitative analysis software was used to examine 120 patients with chronic hepatitis in order to obtain the values for 12 quantitative parameters from the elastic images. The diagnostic performance of two such parameters, the LF index and %AREA, were assessed with a receiver operating characteristic (ROC) curve to determine the optimal diagnostic cut‑off values for liver cirrhosis and fibrosis. A good correlation was observed between the LF index and %AREA with the fibrosis stage. The areas under the ROC curve for the LF index were 0.985 for the diagnosis of liver cirrhosis and 0.790 for liver fibrosis. With regard to %AREA, the areas under the ROC curve for the diagnosis of liver cirrhosis and fibrosis were 0.963 and 0.770, respectively. An LF index of >3.25 and a %AREA of >28.83 for the diagnosis of cirrhosis stage resulted in sensitivity values of 100 and 100%, specificity values of 88.9 and 85.9% and accuracy values of 90.8 and 88.3%, respectively. The LF index and %AREA parameters exhibited higher reliability in the diagnosis of liver cirrhosis compared with the diagnosis of the liver fibrosis stage. However, the two parameters possessed a similar efficacy in the diagnosis of liver cirrhosis and the stage of liver fibrosis. Therefore, the quantitative RTE parameters of the LF index and %AREA may be clinically applicable as reliable indices for the early diagnosis of liver cirrhosis, without the requirement of an invasive procedure.
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ge L, Shi B, Song Y, Li Y, Wang S and Wang X: Clinical value of real‑time elastography quantitative parameters in evaluating the stage of liver fibrosis and cirrhosis. Exp Ther Med 10: 983-990, 2015
APA
Ge, L., Shi, B., Song, Y., Li, Y., Wang, S., & Wang, X. (2015). Clinical value of real‑time elastography quantitative parameters in evaluating the stage of liver fibrosis and cirrhosis. Experimental and Therapeutic Medicine, 10, 983-990. https://doi.org/10.3892/etm.2015.2628
MLA
Ge, L., Shi, B., Song, Y., Li, Y., Wang, S., Wang, X."Clinical value of real‑time elastography quantitative parameters in evaluating the stage of liver fibrosis and cirrhosis". Experimental and Therapeutic Medicine 10.3 (2015): 983-990.
Chicago
Ge, L., Shi, B., Song, Y., Li, Y., Wang, S., Wang, X."Clinical value of real‑time elastography quantitative parameters in evaluating the stage of liver fibrosis and cirrhosis". Experimental and Therapeutic Medicine 10, no. 3 (2015): 983-990. https://doi.org/10.3892/etm.2015.2628