Open Access

MicroRNA‑18a regulates invasive meningiomas via hypoxia‑inducible factor‑1α

  • Authors:
    • Puxian Li
    • Yong Gao
    • Fengjia Li
    • Qiang Pan
    • Zhenrui Liu
    • Xiangdong Lu
    • Chunyu Song
    • Xingtao Diao
  • View Affiliations

  • Published online on: July 8, 2015     https://doi.org/10.3892/etm.2015.2630
  • Pages: 1165-1170
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the effects of microRNA‑18a (miR‑18a) on the invasiveness and metastasis of invasive meningiomas and the underlying mechanism. A total of 69 patients with meningiomas (30 patients in the invasive meningioma group and 39 patients in the non‑invasive meningioma group) and 48 cases in the control group were enrolled. Samples of meningioma tissues, serum and cerebrospinal fluid were collected. Reverse transcription‑quantitative polymerase chain reaction was performed to quantify the expression levels of hypoxia‑inducible factor‑1α (HIF‑1α) mRNA and miR‑18a. Western blot analysis was used to determine protein expression levels of HIF‑1α. The expression levels of HIF‑1α mRNA and protein in all three types of sample from the invasive meningioma group were significantly higher compared with those in the control and non‑invasive meningioma groups (P<0.05), and the expression levels of HIF‑1α mRNA in the serum and cerebrospinal fluid of the non‑invasive meningioma group were significantly higher compared with those in the control group (P<0.05). The expression levels of miR‑18a in the invasive meningioma group were significantly reduced compared with those in the control and non‑invasive meningioma groups (P<0.05), whereas the levels of miR‑18a in the non‑invasive meningioma group were significantly lower compared with those in the control group (P<0.05). The expression of HIF‑1α is significantly upregulated in patients with invasive meningiomas, possibly due to the downregulation of miR‑18a expression. Therefore, miR‑18a may regulate invasive meningiomas via HIF‑1α.
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li P, Gao Y, Li F, Pan Q, Liu Z, Lu X, Song C and Diao X: MicroRNA‑18a regulates invasive meningiomas via hypoxia‑inducible factor‑1α. Exp Ther Med 10: 1165-1170, 2015
APA
Li, P., Gao, Y., Li, F., Pan, Q., Liu, Z., Lu, X. ... Diao, X. (2015). MicroRNA‑18a regulates invasive meningiomas via hypoxia‑inducible factor‑1α. Experimental and Therapeutic Medicine, 10, 1165-1170. https://doi.org/10.3892/etm.2015.2630
MLA
Li, P., Gao, Y., Li, F., Pan, Q., Liu, Z., Lu, X., Song, C., Diao, X."MicroRNA‑18a regulates invasive meningiomas via hypoxia‑inducible factor‑1α". Experimental and Therapeutic Medicine 10.3 (2015): 1165-1170.
Chicago
Li, P., Gao, Y., Li, F., Pan, Q., Liu, Z., Lu, X., Song, C., Diao, X."MicroRNA‑18a regulates invasive meningiomas via hypoxia‑inducible factor‑1α". Experimental and Therapeutic Medicine 10, no. 3 (2015): 1165-1170. https://doi.org/10.3892/etm.2015.2630