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Role and mechanism of vascular cell adhesion molecule-1 in the development of rheumatoid arthritis

  • Authors:
    • Laifang Wang
    • Yanjie Ding
    • Xiaqing Guo
    • Qing Zhao

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  • Published online on: July 15, 2015     https://doi.org/10.3892/etm.2015.2635
  • Pages: 1229-1233
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Abstract

The aim of the present study was to investigate the role and mechanism of vascular cell adhesion molecule-1 (VCAM-1) in the development of rheumatoid arthritis (RA). One hundred and twenty patients with RA who had been admitted to the Huaihe Hospital of Henan University between January and December 2013 were enrolled in the study as the observation group, while, in the corresponding period, 30 healthy volunteers were enrolled as the control group. The serum levels of VCAM‑1 and rheumatoid factor (RF) were detected using ELISA. The patients underwent conventional treatment and their serum VCAM‑1 and RF levels were detected at different time‑points to determine their correlation. The observation group exhibited significantly higher serum VCAM‑1 and RF levels than the control group (P<0.01). Twenty‑four hours after treatment, the serum VCAM‑1 levels of the patients peaked (1,269.47±128.76 µg/l); 36 h after treatment, the serum RF levels peaked (34.42±8.45 U/ml); 1 month after treatment, the VCAM‑1 and serum RF levels of the patients were lower than those prior to treatment (P<0.05). Pearson correlation analysis indicated that there was a significant, positive correlation between the serum VCAM‑1 and RF levels in the patients with RA (r=0.852, P<0.01). In conclusion, the serum VCAM‑1 levels of patients with RA increased and subsequently decreased as the condition was relieved, which could possibly be associated with the autoimmune and inflammatory reactions found in RA. Serum VCAM-1 levels can therefore reflect the disease condition and curative effects of treatment.
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang L, Ding Y, Guo X and Zhao Q: Role and mechanism of vascular cell adhesion molecule-1 in the development of rheumatoid arthritis. Exp Ther Med 10: 1229-1233, 2015
APA
Wang, L., Ding, Y., Guo, X., & Zhao, Q. (2015). Role and mechanism of vascular cell adhesion molecule-1 in the development of rheumatoid arthritis. Experimental and Therapeutic Medicine, 10, 1229-1233. https://doi.org/10.3892/etm.2015.2635
MLA
Wang, L., Ding, Y., Guo, X., Zhao, Q."Role and mechanism of vascular cell adhesion molecule-1 in the development of rheumatoid arthritis". Experimental and Therapeutic Medicine 10.3 (2015): 1229-1233.
Chicago
Wang, L., Ding, Y., Guo, X., Zhao, Q."Role and mechanism of vascular cell adhesion molecule-1 in the development of rheumatoid arthritis". Experimental and Therapeutic Medicine 10, no. 3 (2015): 1229-1233. https://doi.org/10.3892/etm.2015.2635