Assessment of carboprost tromethamine for reducing hemorrhage in laparoscopic intramural myomectomy

Zhang,Ruitao; Shi,Huirong; Ren,Fang; Yuan,Zhongfu

doi:10.3892/etm.2015.2649

September-2015 Volume 10 Issue 3

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September-2015 Volume 10 Issue 3

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Article

Assessment of carboprost tromethamine for reducing hemorrhage in laparoscopic intramural myomectomy

Authors:
- Ruitao Zhang
- Huirong Shi
- Fang Ren
- Zhongfu Yuan
View Affiliations / Copyright

Affiliations: Department of Gynecology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Pages: 1171-1174
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Published online on: July 20, 2015

https://doi.org/10.3892/etm.2015.2649
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Abstract

The aim of the present study was to evaluate the effect of carboprost tromethamine on blood loss during laparoscopic myomectomy (LM) in females. Ninety women, who were scheduled for LM due to symptomatic uterine myomas, were randomly divided into three groups. Twenty‑four women were intramyometrially injected with 12 IU diluted vasopressin (vasopressin group), 30 cases received a deep intramuscular injection of 250 µg carboprost tromethamine 30 min prior to myomectomy (carboprost group), and 36 cases received an intramuscular injection of 250 µg carboprost tromethamine followed by a 20 IU oxytocin intravenous infusion at a rate of 120 mU/min during the procedure (carboprost plus oxytocin group). The procedure time, amount of hemorrhage, postoperative reduction in hemoglobin levels, adverse effects, bowel deflation time and time of postoperative hospital stay were compared. The procedure time, amount of hemorrhage and postoperative reduction in hemoglobin levels were not significantly different between the carboprost group and the vasopressin group (P>0.05). In the carboprost plus oxytocin group, the procedure time, amount of hemorrhage and postoperative reduction in hemoglobin levels were 24.3±2.6 min, 51.1±8.4 ml and 6.9±1.5 g/l, respectively, which were significantly less than those in the vasopressin and carboprost groups (all P<0.05). In the carboprost and carboprost plus oxytocin groups, the incidence of mild uterine contraction pain was significantly higher than in the vasopressin group (χ2=12.913, P=0.002). The incidences of other side‑effects were not significantly different among the three groups. The times for bowel deflation and postoperative hospital stay were marginally increased in both the carboprost and carboprost plus oxytocin groups, compared with the vasopressin group, although no significant differences were found among the three groups (P>0.05). Deep intramuscular injections of carboprost tromethamine prior to performing myomectomy could be an effective approach for reducing blood loss from intramural LM, in particular when combined with oxytocin intravenous infusion.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Assessment of carboprost tromethamine for reducing hemorrhage in laparoscopic intramural myomectomy

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