Clinical efficacy of propranolol in the treatment of hemangioma and changes in serum VEGF, bFGF and MMP-9

  • Authors:
    • Shanying Wu
    • Biao Wang
    • Lifen Chen
    • Shuyuan Xiong
    • Fulian Zhuang
    • Xunlei Huang
    • Meishui Wang
    • Zugen Huang
  • View Affiliations

  • Published online on: July 20, 2015     https://doi.org/10.3892/etm.2015.2650
  • Pages: 1079-1083
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Abstract

The aim of this study was to observe the clinical efficacy and safety of propranolol in the treatment of hemangioma, and to reveal its possible mechanism. A total of 129 cases of proliferative hemangioma were divided into two groups: i) Treatment (n=97), in which the patients received oral propranolol therapy and ii) observation (n=32), in which the patients underwent clinical observation. The changes in the hemangiomas were noted and compared between the two groups. In addition, the heart rate, blood glucose levels, liver, kidney and thyroid function of the patients in the treatment group were monitored prior to and following treatment; the ELISA method was used for the measurement of the patients' serum concentrations of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and matrix metalloproteinase‑9 (MMP‑9) at the same time‑points. A significant difference in curative effect was found between the treatment and observation group. The concentration of free thyroxine and sensitive thyroid‑stimulating hormone and the heart rate of the treatment group exhibited significant changes prior to and following medication, but no statistical significance was found in the changes in blood glucose, liver and kidney function and free triiodothyronine concentration. Furthermore, the serum concentrations of VEGF, bFGF and MMP‑9 in the treatment group 8 weeks after medication were decreased significantly compared with those before treatment. In conclusion, oral propranolol has a good curative effect in the treatment of proliferative hemangioma, with few side effects and a high level of safety. The mechanism underlying the effects of propranolol may be associated with the downregulation of VEGF, bFGF and MMP-9 expression.
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wu S, Wang B, Chen L, Xiong S, Zhuang F, Huang X, Wang M and Huang Z: Clinical efficacy of propranolol in the treatment of hemangioma and changes in serum VEGF, bFGF and MMP-9. Exp Ther Med 10: 1079-1083, 2015
APA
Wu, S., Wang, B., Chen, L., Xiong, S., Zhuang, F., Huang, X. ... Huang, Z. (2015). Clinical efficacy of propranolol in the treatment of hemangioma and changes in serum VEGF, bFGF and MMP-9. Experimental and Therapeutic Medicine, 10, 1079-1083. https://doi.org/10.3892/etm.2015.2650
MLA
Wu, S., Wang, B., Chen, L., Xiong, S., Zhuang, F., Huang, X., Wang, M., Huang, Z."Clinical efficacy of propranolol in the treatment of hemangioma and changes in serum VEGF, bFGF and MMP-9". Experimental and Therapeutic Medicine 10.3 (2015): 1079-1083.
Chicago
Wu, S., Wang, B., Chen, L., Xiong, S., Zhuang, F., Huang, X., Wang, M., Huang, Z."Clinical efficacy of propranolol in the treatment of hemangioma and changes in serum VEGF, bFGF and MMP-9". Experimental and Therapeutic Medicine 10, no. 3 (2015): 1079-1083. https://doi.org/10.3892/etm.2015.2650