|
1
|
Einhorn T: Enhancement of
fracture-healing. J Bone Joint Surg Am. 77:940–956. 1995.PubMed/NCBI
|
|
2
|
O'Neill KR, Stutz CM, Mignemi NA, et al:
Micro-computed tomography assessment of the progression of fracture
healing in mice. Bone. 50:1357–1367. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Mizushima N, Levine B, Cuervo AM and
Klionsky DJ: Autophagy fights disease through cellular
self-digestion. Nature. 451:1069–1075. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Levine B and Kroemer G: Autophagy in the
pathogenesis of disease. Cell. 132:27–42. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Mathew R, Karp CM, Beaudoin B, et al:
Autophagy suppresses tumorigenesis through elimination of p62.
Cell. 137:1062–1075. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Hara T, Nakamura K, Matsui M, et al:
Suppression of basal autophagy in neural cells causes
neurodegenerative disease in mice. Nature. 441:885–889. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Komatsu M, Waguri S, Ueno T, et al:
Impairment of starvation-induced and constitutive autophagy in
Atg7-deficient mice. J Cell Biol. 169:425–434. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Shibata M, Lu T, Furuya T, et al:
Regulation of intracellular accumulation of mutant Huntingtin by
Beclin 1. J Biol Chem. 281:14474–14485. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Su JC, Tseng PH, Hsu CY, et al:
RFX1-dependent activation of SHP-1 induces autophagy by a novel
obatoclax derivative in hepatocellular carcinoma cells. Oncotarget.
5:4909–4919. 2014.PubMed/NCBI
|
|
10
|
Wullschleger S, Loewith R and Hall MN: TOR
signaling in growth and metabolism. Cell. 124:471–484. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Dann SG, Selvaraj A and Thomas G: mTOR
Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and
cancer. Trends Mol Med. 13:252–259. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Shigemitsu K, Tsujishita Y, Hara K,
Nanahoshi M, Avruch J and Yonezawa K: Regulation of translational
effectors by amino acid and mammalian target of rapamycin signaling
pathways. Possible involvement of autophagy in cultured hepatoma
cells. J Biol Chem. 274:1058–1065. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Sabers CJ, Martin MM, Brunn GJ, et al:
Isolation of a protein target of the FKBP12-rapamycin complex in
mammalian cells. J Biol Chem. 270:815–822. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Sarkar S and Rubinsztein DC: Huntington's
disease: Degradation of mutant huntingtin by autophagy. FEBS J.
275:4263–4270. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Harrison DE, Strong R, Sharp ZD, et al:
Rapamycin fed late in life extends lifespan in genetically
heterogeneous mice. Nature. 460:392–395. 2009.PubMed/NCBI
|
|
16
|
Pan T, Rawal P, Wu Y, Xie W, Jankovic J
and Le W: Rapamycin protects against rotenone-induced apoptosis
through autophagy induction. Neuroscience. 164:541–551. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Spilman P, Podlutskaya N, Hart MJ, et al:
Inhibition of mTOR by rapamycin abolishes cognitive deficits and
reduces amyloid-beta levels in a mouse model of Alzheimer's
disease. PLoS One. 5:e99792010. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Inuzuka Y, Okuda J, Kawashima T, et al:
Suppression of phosphoinositide 3-kinase prevents cardiac aging in
mice. Circulation. 120:1695–1703. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Holstein JH, Menger MD, Culemann U, Meier
C and Pohlemann T: Development of a locking femur nail for mice. J
Biomech. 40:215–219. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Müller ME, Nazarian S, Koch P and
Schatzker J: The Comprehensive Classification of Fractures of Long
Bones. 1st edition. Springer; New York, NY: 1994
|
|
21
|
Ekim B, Magnuson B, AcostaJaquez HA,
Keller JA, Feener EP and Fingar DC: mTOR kinase domain
phosphorylation promotes mTORC1 signaling, cell growth and cell
cycle progression. Mol Cell Biol. 31:2787–2801. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Moscat J and Diaz-Meco MT: p62 at the
crossroads of autophagy, apoptosis and cancer. Cell. 137:1001–1004.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Lin NY, Stefanica A and Distler JH:
Autophagy: A key pathway of TNF-induced inflammatory bone loss.
Autophagy. 9:1253–1255. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Zhang L, Guo YF, Liu YZ, et al:
Pathway-based genome-wide association analysis identified the
importance of regulation-of-autophagy pathway for ultradistal
radius BMD. J Bone Miner Res. 25:1572–1580. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Zoncu R, Efeyan A and Sabatini DM: mTOR:
From growth signal integration to cancer, diabetes and ageing. Nat
Rev Mol Cell Biol. 12:21–35. 2011. View
Article : Google Scholar : PubMed/NCBI
|
|
26
|
Guertin DA and Sabatini DM: The
pharmacology of mTOR inhibition. Sci Signal. 2:pe242009.PubMed/NCBI
|
|
27
|
Yu X, Guo Y, Kang Q and Luo C: Effects and
mechanisms of mechanical stress on secondary fracture healing.
Front Biosci (Landmark Ed). 18:1344–1348. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Keramaris NC, Calori GM, Nikolaou VS,
Schemitsch EH and Giannoudis PV: Fracture vascularity and bone
healing: A systematic review of the role of VEGF. Injury. 39 (Suppl
2):S45–S57. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Morrow PW, Tung HY and Hemmings HC Jr:
Rapamycin causes activation of protein phosphatase-2A1 and nuclear
translocation of PCNA in CD4+ T cells. Biochem Biophys
Res Commun. 323:645–651. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Kobayashi S, Kishimoto T, Kamata S, Otsuka
M, Miyazaki M and Ishikura H: Rapamycin, a specific inhibitor of
the mammalian target of rapamycin, suppresses lymphangiogenesis and
lymphatic metastasis. Cancer Sci. 98:726–733. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Kawahara T, Asthana S and Kneteman NM:
m-TOR inhibitors: What role in liver transplantation? J Hepatol.
55:1441–1451. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Cirstea D, Hideshima T, Rodig S, et al:
Dual inhibition of Akt/mammalian target of rapamycin pathway by
nanoparticle albumin-bound-rapamycin and perifosine induces
antitumor activity in multiple myeloma. Mol Cancer Ther. 9:963–975.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Caramés B, Taniguchi N, Otsuki S, Blanco
FJ and Lotz M: Autophagy is a protective mechanism in normal
cartilage and its aging-related loss is linked with cell death and
osteoarthritis. Arthritis Rheum. 62:791–801. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Wong E and Cuervo AM: Autophagy gone awry
in neurodegenerative diseases. Nat Neurosci. 13:805–811. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Chen K, Yang YH, Jiang SD and Jiang LS:
Decreased activity of osteocyte autophagy with aging may contribute
to the bone loss in senile population. Histochem Cell Biol.
142:285–295. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Stanfel MN, Shamieh LS, Kaeberlein M and
Kennedy BK: The TOR pathway comes of age. Biochim Biophys Acta.
1790:1067–1074. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Sciarretta S, Volpe M and Sadoshima J:
Mammalian target of rapamycin signaling in cardiac physiology and
disease. Circ Res. 114:549–564. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Mirzaei H and Longo VD: Acetyl-CoA
synthetase is a conserved regulator of autophagy and life span.
Cell Metab. 19:555–557. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Holstein JH, Klein M, Garcia P, et al:
Rapamycin affects early fracture healing in mice. Br J Pharmacol.
154:1055–1062. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Wagner R, Mollison KW, Liu L, et al:
Rapamycin analogs with reduced systemic exposure. Bioorg Med Chem
Lett. 15:5340–5343. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Holstein JH, Klein M, Garcia P, Histing T,
Culemann U, Pizanis A, Laschke MW, Scheuer C, Meier C, Schorr H, et
al: Rapamycin affects early fracture healing in mice. Br J
Pharmacol. 154:1055–1062. 2008. View Article : Google Scholar : PubMed/NCBI
|
