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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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Case Report Open Access

Nitrogen mustard hydrochloride-induced acute respiratory failure and myelosuppression: A case report

  • Authors:
    • Xiaojuan Zhang
    • Zhidan Zhang
    • Song Chen
    • Dongmei Zhao
    • Fangxiao Zhang
    • Ziwei Hu
    • Feng Xiao
    • Xiaochun Ma
  • View Affiliations / Copyright

    Affiliations: Intensive Care Unit, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1293-1296
    |
    Published online on: July 29, 2015
       https://doi.org/10.3892/etm.2015.2664
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Abstract

Nitrogen mustards are chemical agents that are similar to sulfur mustards, with similar toxicities. The present study describes a case of nitrogen mustard‑induced acute respiratory failure and myelosuppression in a 33‑year‑old man. The patient, who was accidentally exposed to nitrogen mustard hydrochloride in a pharmaceutical factory, exhibited severe inhalation injury and respiratory symptoms. Laboratory tests revealed reduced white blood cell counts and lowered platelet levels during the first 6 days after the skin exposure to nitrogen mustard. Following treatment with mechanical ventilation, immunity‑enhancing agents and nutritional supplements for 1 month, the patient successfully recovered and was released from hospital.
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1 

Ma HJ, Zhao G, Shi F and Wang YX: Eruptive cherry angiomas associated with vitiligo: Provoked by topical nitrogen mustard? J Dermatol. 33:877–879. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Abel EA, Sendagorta E and Hoppe RT: Cutaneous malignancies and metastatic squamous cell carcinoma following topical therapies for mycosis fungoides. J Am Acad Dermatol. 14:1029–1038. 1986. View Article : Google Scholar : PubMed/NCBI

3 

Zhu LL, Zheng S, Wei H, Hong YX, Zhang L, Zhang L, Chen HD and Gao XH: Multiple cutaneous malignancies and cherry hemangiomas in a vitiligo patient treated with topical nitrogen mustard. Dermatol Ther. 27:52–54. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Weinberger B, Laskin JD, Sunil VR, Sinko PJ, Heck DE and Laskin DL: Sulfur mustard-induced pulmonary injury: Therapeutic approaches to mitigating toxicity. Pulm Pharmacol Ther. 24:92–99. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Malaviya R, Sunil VR, Cervelli J, Anderson DR, Holmes WW, Conti ML, Gordon RE, Laskin JD and Laskin DL: Inflammatory effects of inhaled sulfur mustard in rat lung. Toxicol Appl Pharmacol. 248:89–99. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Shakarjian MP, Heck DE, Gray JP, Sinko PJ, Gordon MK, Casillas RP, Heindel ND, Gerecke DR, Laskin DL and Laskin JD: Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure. Toxicol Sci. 114:5–19. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Wang GQ and Xia ZF: Tissue injury by hot fluid containing nitrogen mustard. Burns. 33:923–926. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Sunil VR, Vayas KN, Cervelli JA, Malaviya R, Hall L, Massa CB, Gow AJ, Laskin JD and Laskin DL: Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation. Exp Mol Pathol. 97:89–98. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Macit E, Yaren H, Aydin I, Kunak ZI, Yaman H, Onguru O, Uysal B, Korkmaz A, Turel S and Kenar L: The protective effect of melatonin and S-methylisothiourea treatments in nitrogen mustard induced lung toxicity in rats. Environ Toxicol Pharmacol. 36:1283–1290. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Sunil VR, Patel KJ, Shen J, Reimer D, Gow AJ, Laskin JD and Laskin DL: Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard. Toxicol Appl Pharmacol. 250:10–18. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Malaviya R, Venosa A, Hall L, Gow AJ, Sinko PJ, Laskin JD and Laskin DL: Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor. Toxicol Appl Pharmacol. 265:279–291. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Osterlund C, Lilliehöök B, Ekstrand-Hammarström B, Sandström T and Bucht A: The nitrogen mustard melphalan activates mitogen-activated phosphorylated kinases (MAPK), nuclear factor-kappaB and inflammatory response in lung epithelial cells. J Appl Toxicol. 25:328–337. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Ucar M, Korkmaz A, Reiter RJ, Yaren H, Oter S, Kurt B and Topal T: Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard. Toxicol Lett. 173:124–131. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Ramsay DL, Meller JA and Zackheim HS: Topical treatment of early cutaneous T-cell lymphoma. Hematol Oncol Clin North Am. 9:1031–1056. 1995.PubMed/NCBI

15 

Xie J, Shults K, Flye L, Jiang F, Head DR and Briggs RC: Overexpression of GSTA2 protects against cell cycle arrest and apoptosis induced by the DNA inter-strand crosslinking nitrogen mustard, mechlorethamine. J Cell Biochem. 95:339–351. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Inturi S, TewariSingh N, Agarwal C, White CW and Agarwal R: Activation of DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes. Mutat Res 763–764. 53–63. 2014. View Article : Google Scholar

17 

DeAlencar TA, Leitão AC and Lage C: Nitrogen mustard- and half-mustard-induced damage in Escherichia coli requires different DNA repair pathways. Mutat Res. 582:105–115. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Eldad A, Weinberg A, Breiterman S, Chaouat M, Palanker D and Ben-Bassat H: Early nonsurgical removal of chemically injured tissue enhances wound healing in partial thickness burns. Burns. 24:166–172. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Rappeneau S, BaezaSquiban A, Jeulin C and Marano F: Protection from cytotoxic effects induced by the nitrogen mustard mechlorethamine on human bronchial epithelial cells in vitro. Toxicol Sci. 54:212–221. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Hugel B, Weltin D, Holl V, Marchal J, Dufour P, Freyssinet JM and Bischoff PL: Assessment of apoptosis occurring in spleen cells from nitrogen mustard-treated or gamma-irradiated mice. Anticancer Res. 18:3289–3294. 1998.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Zhang Z, Chen S, Zhao D, Zhang F, Hu Z, Xiao F and Ma X: Nitrogen mustard hydrochloride-induced acute respiratory failure and myelosuppression: A case report. Exp Ther Med 10: 1293-1296, 2015.
APA
Zhang, X., Zhang, Z., Chen, S., Zhao, D., Zhang, F., Hu, Z. ... Ma, X. (2015). Nitrogen mustard hydrochloride-induced acute respiratory failure and myelosuppression: A case report. Experimental and Therapeutic Medicine, 10, 1293-1296. https://doi.org/10.3892/etm.2015.2664
MLA
Zhang, X., Zhang, Z., Chen, S., Zhao, D., Zhang, F., Hu, Z., Xiao, F., Ma, X."Nitrogen mustard hydrochloride-induced acute respiratory failure and myelosuppression: A case report". Experimental and Therapeutic Medicine 10.4 (2015): 1293-1296.
Chicago
Zhang, X., Zhang, Z., Chen, S., Zhao, D., Zhang, F., Hu, Z., Xiao, F., Ma, X."Nitrogen mustard hydrochloride-induced acute respiratory failure and myelosuppression: A case report". Experimental and Therapeutic Medicine 10, no. 4 (2015): 1293-1296. https://doi.org/10.3892/etm.2015.2664
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Zhang Z, Chen S, Zhao D, Zhang F, Hu Z, Xiao F and Ma X: Nitrogen mustard hydrochloride-induced acute respiratory failure and myelosuppression: A case report. Exp Ther Med 10: 1293-1296, 2015.
APA
Zhang, X., Zhang, Z., Chen, S., Zhao, D., Zhang, F., Hu, Z. ... Ma, X. (2015). Nitrogen mustard hydrochloride-induced acute respiratory failure and myelosuppression: A case report. Experimental and Therapeutic Medicine, 10, 1293-1296. https://doi.org/10.3892/etm.2015.2664
MLA
Zhang, X., Zhang, Z., Chen, S., Zhao, D., Zhang, F., Hu, Z., Xiao, F., Ma, X."Nitrogen mustard hydrochloride-induced acute respiratory failure and myelosuppression: A case report". Experimental and Therapeutic Medicine 10.4 (2015): 1293-1296.
Chicago
Zhang, X., Zhang, Z., Chen, S., Zhao, D., Zhang, F., Hu, Z., Xiao, F., Ma, X."Nitrogen mustard hydrochloride-induced acute respiratory failure and myelosuppression: A case report". Experimental and Therapeutic Medicine 10, no. 4 (2015): 1293-1296. https://doi.org/10.3892/etm.2015.2664
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