Open Access

Efficacy and safety evaluation of citalopram and doxepin on sleep quality in comorbid insomnia and anxiety disorders

  • Authors:
    • Junfeng Wu
    • Fei Chang
    • Hengbing Zu
  • View Affiliations

  • Published online on: August 17, 2015     https://doi.org/10.3892/etm.2015.2686
  • Pages: 1303-1308
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Anxiety disorders are frequently comorbid with insomnia, and sleep disturbance in patients with anxiety disorders is the most common complaint. Antidepressants can affect sleep quality; however, their effect in patients with comorbid insomnia and anxiety disorders is unclear. The aim of the present study was to comprehensively evaluate the dose, treatment duration, treatment efficacy and safety of clinical citalopram and doxepin application in patients with comorbid insomnia and anxiety disorders. It was found that both citalopram (20 mg/day) and low‑dose doxepin (12.5 mg/day) significantly improved sleep latency, duration and disturbances, as well as daytime dysfunction and the global Pittsburgh Sleep Quality Index during the 12‑week treatment period. Notably, low‑dose doxepin significantly improved sleep latency in patients after treatment for 8 and 12 weeks as compared with citalopram. It was further observed that both citalopram and low‑dose doxepin improved anxiety. A significant and positive correlation was found between the improvement in the sleep quality and anxiety in the two treatment groups. Citalopram and low‑dose doxepin both showed good efficacy and a low adverse reaction rate in the treated patients. These data support a potential application of citalopram and low‑dose doxepin in the treatment of patients with comorbid insomnia and anxiety disorders.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wu J, Chang F and Zu H: Efficacy and safety evaluation of citalopram and doxepin on sleep quality in comorbid insomnia and anxiety disorders. Exp Ther Med 10: 1303-1308, 2015
APA
Wu, J., Chang, F., & Zu, H. (2015). Efficacy and safety evaluation of citalopram and doxepin on sleep quality in comorbid insomnia and anxiety disorders. Experimental and Therapeutic Medicine, 10, 1303-1308. https://doi.org/10.3892/etm.2015.2686
MLA
Wu, J., Chang, F., Zu, H."Efficacy and safety evaluation of citalopram and doxepin on sleep quality in comorbid insomnia and anxiety disorders". Experimental and Therapeutic Medicine 10.4 (2015): 1303-1308.
Chicago
Wu, J., Chang, F., Zu, H."Efficacy and safety evaluation of citalopram and doxepin on sleep quality in comorbid insomnia and anxiety disorders". Experimental and Therapeutic Medicine 10, no. 4 (2015): 1303-1308. https://doi.org/10.3892/etm.2015.2686