Nilotinib rapidly reverses breakpoint cluster region-Abelson oncogene fusion gene and M244V mutations in a patient with chronic myelogenous leukemia: A case report

Shen,Xuliang; Zhang,Meixiang; Shen,Yifan; Shi,Wenzhi; Liu,Wei; Wei,Wu

doi:10.3892/etm.2015.2707

October-2015 Volume 10 Issue 4

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October-2015 Volume 10 Issue 4

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Case Report

Nilotinib rapidly reverses breakpoint cluster region-Abelson oncogene fusion gene and M244V mutations in a patient with chronic myelogenous leukemia: A case report

Authors:
- Xuliang Shen
- Meixiang Zhang
- Yifan Shen
- Wenzhi Shi
- Wei Liu
- Wu Wei
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Affiliations: Department of Hematology, Heping Hospital of Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China, Department of Hematology, Beijing Rehabilitation Hospital of Capital Medical University, Beijing 100144, P.R. China, Department of Hematology, Heji Hospital of Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China
Pages: 1479-1482
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Published online on: August 24, 2015

https://doi.org/10.3892/etm.2015.2707
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Abstract

Chronic myelogenous leukemia (CML) is a condition characterized by a balanced genetic translocation, t (9;22) (q34;q11.2), which leads to a fusion of the Abelson oncogene (ABL) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome 22q11.2. This rearrangement is referred to as the Philadelphia chromosome. At a molecular level, this translocation results in the formation of the BCR‑ABL fusion oncogene, which translates into a BCR‑ABL oncoprotein. Imatinib, nilotinib and dasatinib are three tyrosine kinase inhibitors that have been approved by the US Food and Drug Administration for the treatment of patients diagnosed with CML in the chronic phase (CML‑CP). The present study describes the case of a patient with imatinib‑resistant CML who, following two months of treatment with nilotinib, no longer exhibited detectable BCR‑ABL fusion genes or M244V mutations. This suggests that nilotinib may be effective for treating CML cases in which the BCR‑ABL fusion protein has an M244V mutation.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Nilotinib rapidly reverses breakpoint cluster region-Abelson oncogene fusion gene and M244V mutations in a patient with chronic myelogenous leukemia: A case report

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