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Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction

  • Authors:
    • Yan Li
    • Liqun Li
    • Fengyun Dong
    • Ling Guo
    • Yinglong Hou
    • Hesheng Hu
    • Suhua Yan
    • Xiaojun Zhou
    • Lin Liao
    • Thaddeus D. Allen
    • Ju Liu
  • View Affiliations / Copyright

    Affiliations: Children's Health Care Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China, Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China, Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China, Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China, G.W. Hooper Research Foundation, University of California at San Francisco, San Francisco, CA 94143‑0552, USA
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1743-1749
    |
    Published online on: September 1, 2015
       https://doi.org/10.3892/etm.2015.2721
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Abstract

The von Willebrand factor (vWF) is a plasma glycoprotein that plays an essential role in hemostasis by supporting platelet adhesion and thrombus formation in response to vascular injury. Plasma levels of vWF are an independent risk factor for patients with acute myocardial infarction (AMI); however, clinical data have demonstrated a marked variation of vWF levels in patients with AMI, the reason for which has not yet been identified. In the present study, a rat model of ST‑segment elevation AMI was established, and cardiac and peripheral blood was collected for a time‑course examination of the plasma levels of vWF and tumor necrosis factor‑α (TNF‑α). The level of vWF in the blood plasma increased, peaked at 1 h and decreased to normal levels by day 7 following AMI, while the level of TNF‑α peaked at 24 h and remained elevated until day 7. The effects of TNF‑α on vWF secretion and expression were examined in cultured human umbilical vascular endothelial cells (HUVECs). TNF‑α treatment increased vWF secretion from the HUVECs but inhibited the mRNA and protein expression of vWF in the HUVECs. These results indicate that vWF secretion from endothelial cells is transiently elevated following AMI, and then decreases as the expression of vWF is inhibited by TNF‑α. The present study increases the understanding of the pathophysiology of vWF and indicates that the determination of vWF levels may be useful in the clinical evaluation of AMI.
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View References

1 

Ruggeri ZM: Von Willebrand factor, platelets and endothelial cell interactions. J Thromb Haemost. 1:1335–1342. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Lenting PJ, Christophe OD and Denis CV: von Willebrand factor biosynthesis, secretion and clearance: Connecting the far ends. Blood. 125:2019–2028. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Sadler JE: von Willebrand factor assembly and secretion. J Thromb Haemost. 7(Suppl 1): S24–S27. 2009. View Article : Google Scholar

4 

Kanaji S, Fahs SA, Shi Q, Haberichter SL and Montgomery RR: Contribution of platelet vs. endothelial VWF to platelet adhesion and hemostasis. J Thromb Haemost. 10:1646–1652. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Metcalf DJ, Nightingale TD, Zenner HL, Lui-Roberts WW and Cutler DF: Formation and function of Weibel-Palade bodies. J Cell Sci. 121:19–27. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Nightingale T and Cutler D: The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story. J Thromb Haemost. 11(Suppl 1): S192–S201. 2013. View Article : Google Scholar

7 

Yee A and Kretz CA: Von Willebrand factor: Form for function. Semin Thromb Hemost. 40:17–27. 2014.PubMed/NCBI

8 

Lenting PJ, Pegon JN, Groot E and de Groot PG: Regulation of von Willebrand factor-platelet interactions. Thromb Haemost. 104:449–455. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Franchini M, Frattini F, Crestani S, Bonfanti C and Lippi G: von Willebrand factor and cancer: A renewed interest. Thromb Res. 131:290–292. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Lenting PJ, Casari C, Christophe OD and Denis CV: von Willebrand factor: The old, the new and the unknown. J Thromb Haemost. 10:2428–2437. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Randi AM, Laffan MA and Starke RD: Von Willebrand factor, angiodysplasia and angiogenesis. Mediterr J Hematol Infect Dis. 5:e20130602013. View Article : Google Scholar : PubMed/NCBI

12 

Jahroudi N and Lynch DC: Endothelial-cell-specific regulation of von Willebrand factor gene expression. Mol Cell Biol. 14:999–1008. 1994.PubMed/NCBI

13 

Lillicrap D: von Willebrand disease: Advances in pathogenetic understanding, diagnosis and therapy. Blood. 122:3735–3740. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Yamamoto K, de Waard V, Fearns C and Loskutoff DJ: Tissue distribution and regulation of murine von Willebrand factor gene expression in vivo. Blood. 92:2791–2801. 1998.PubMed/NCBI

15 

Aird WC, Jahroudi N, Weiler-Guettler H, Rayburn HB and Rosenberg RD: Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice. Proc Natl Acad Sci USA. 92:4567–4571. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Aird WC, Edelberg JM, Weiler-Guettler H, Simmons WW, Smith TW and Rosenberg RD: Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment. J Cell Biol. 138:1117–1124. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Bertagna A and Jahroudi N: The NFY transcription factor mediates induction of the von Willebrand factor promoter by irradiation. Thromb Haemost. 85:837–844. 2001.PubMed/NCBI

18 

Liu J, Kanki Y, Okada Y, Jin E, Yano K, Shih SC, Minami T and Aird WC: A +220 GATA motif mediates basal but not endotoxin-repressible expression of the von Willebrand factor promoter in Hprt-targeted transgenic mice. J Thromb Haemost. 7:1384–1392. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Mojiri A, Nakhaii-Nejad M, Phan WL, Kulak S, Radziwon-Balicka A, Jurasz P, Michelakis E and Jahroudi N: Hypoxia results in upregulation and de novo activation of von Willebrand factor expression in lung endothelial cells. Arterioscler, Thromb Vasc Biol. 33:1329–1338. 2013. View Article : Google Scholar

20 

Kleinschmidt AM, Nassiri M, Stitt MS, Wasserloos K, Watkins SC, Pitt BR and Jahroudi N: Sequences in intron 51 of the von Willebrand factor gene target promoter activation to a subset of lung endothelial cells in transgenic mice. J Biol Chem. 283:2741–2750. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Nassiri M, Liu J, Kulak S, Uwiera RR, Aird WC, Ballermann BJ and Jahroudi N: Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice. Arterioscler, Thromb Vasc Biol. 30:1423–1429. 2010. View Article : Google Scholar

22 

Paulinska P, Spiel A and Jilma B: Role of von Willebrand factor in vascular disease. Hamostaseologie. 29:32–38. 2009.PubMed/NCBI

23 

Spiel AO, Gilbert JC and Jilma B: von Willebrand factor in cardiovascular disease: Focus on acute coronary syndromes. Circulation. 117:1449–1459. 2008. View Article : Google Scholar : PubMed/NCBI

24 

White HD and Chew DP: Acute myocardial infarction. Lancet. 372:570–584. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Hori M and Nishida K: Oxidative stress and left ventricular remodelling after myocardial infarction. Cardiovasc Res. 81:457–464. 2009. View Article : Google Scholar : PubMed/NCBI

26 

White HD, Thygesen K, Alpert JS and Jaffe AS: Clinical implications of the third universal definition of myocardial infarction. Heart. 100:424–432. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Peyvandi F, Hollestelle MJ, Palla R, Merlini PA, Feys HB, Vanhoorelbeke K, Lenting PJ and Mannucci PM: Active platelet-binding conformation of plasma von Willebrand factor in young women with acute myocardial infarction. J Haemost. 8:1653–1656. 2010. View Article : Google Scholar

28 

Goto S, Sakai H, Ikeda Y and Handa S: Acute myocardial infarction plasma augments platelet thrombus growth in high shear rates. Lancet. 349:543–544. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Jansson JH, Nilsson TK and Johnson O: von Willebrand factor in plasma: A novel risk factor for recurrent myocardial infarction and death. Br Heart J. 66:351–355. 1991. View Article : Google Scholar : PubMed/NCBI

30 

Chion CK, Doggen CJ, Crawley JT, Lane DA and Rosendaal FR: ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men. Blood. 109:1998–2000. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Hu H, Xuan Y, Wang Y, Xue M, Suo F, Li X, Cheng W, Li X, Yin J, Liu J and Yan S: Targeted NGF siRNA delivery attenuates sympathetic nerve sprouting and deteriorates cardiac dysfunction in rats with myocardial infarction. PloS One. 9:e951062014. View Article : Google Scholar : PubMed/NCBI

32 

Wang Y, Liu J, Suo F, Hu HS, Xue M, Cheng WJ, Xuan YL and Yan SH: Metoprolol-mediated amelioration of sympathetic nerve sprouting after myocardial infarction. Cardiology. 126:50–58. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Zhang WB, Du QJ, Li H, Sun AJ, Qiu ZH, Wu CN, Zhao G, Gong H, Hu K, Zou YZ and Ge JB: The therapeutic effect of rosuvastatin on cardiac remodelling from hypertrophy to fibrosis during the end-stage hypertension in rats. J Cell Mol Med. 16:2227–2237. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Liu J, Yuan L, Molema G, Regan E, Janes L, Beeler D, Spokes KC, Okada Y, Minami T, Oettgen P and Aird WC: Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle. Blood. 117:342–351. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Rutten B, Maseri A, Cianflone D, Laricchia A, Cristell NA, Durante A, Spartera M, Ancona F, Limite L, Hu D, et al: Plasma levels of active Von Willebrand factor are increased in patients with first ST-segment elevation myocardial infarction: A multicenter and multiethnic study. Eur Heart J Acute Cardiovasc Care. 4:64–74. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Sakai H, Goto S, Kim JY, Aoki N, Abe S, Ichikawa N, Yoshida M, Nagaoka Y and Handa S: Plasma concentration of von Willebrand factor in acute myocardial infarction. Thromb Haemost. 84:204–209. 2000.PubMed/NCBI

37 

Frangogiannis NG, Smith CW and Entman ML: The inflammatory response in myocardial infarction. Cardiovasc Res. 53:31–47. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Dinarello CA and Pomerantz BJ: Proinflammatory cytokines in heart disease. Blood Purif. 19:314–321. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Hall G, Hasday JD and Rogers TB: Regulating the regulator: NF-kappaB signaling in heart. J Mol Cell Cardiol. 41:580–591. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Kleinbongard P, Schulz R and Heusch G: TNFα in myocardial ischemia/reperfusion, remodeling and heart failure. Heart Fail Rev. 16:49–69. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Mann DL: Tumor necrosis factor-induced signal transduction and left ventricular remodeling. J Card Fail. 8(Suppl 6): S379–S386. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Bradham WS, Bozkurt B, Gunasinghe H, Mann D and Spinale FG: Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: A current perspective. Cardiovasc Res. 53:822–830. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Jacobs M, Staufenberger S, Gergs U, Meuter K, Brandstätter K, Hafner M, Ertl G and Schorb W: Tumor necrosis factor-alpha at acute myocardial infarction in rats and effects on cardiac fibroblasts. J Mol Cell Cardiol. 31:1949–1959. 1999. View Article : Google Scholar : PubMed/NCBI

44 

Blake GJ: Inflammatory biomarkers of the patient with myocardial insufficiency. Curr Opin Crit Care. 9:369–374. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Schulz R, Aker S, Belosjorow S and Heusch G: TNFalpha in ischemia/reperfusion injury and heart failure. Basic Res Cardiol. 99:8–11. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Zhang H, Park Y, Wu J, Chen Xp, Lee S, Yang J, Dellsperger KC and Zhang C: Role of TNF-alpha in vascular dysfunction. Clin Sci (Lond). 116:219–230. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Madge LA and Pober JS: TNF signaling in vascular endothelial cells. Exp Mol Pathol. 70:317–325. 2001. View Article : Google Scholar : PubMed/NCBI

48 

van der Poll T, van Deventer SJ, Pasterkamp G, van Mourik JA, Büller HR and ten Cate JW: Tumor necrosis factor induces von Willebrand factor release in healthy humans. Thromb Haemost. 67:623–626. 1992.PubMed/NCBI

49 

Umetani M, Mataki C, Minegishi N, Yamamoto M, Hamakubo T and Kodama T: Function of GATA transcription factors in induction of endothelial vascular cell adhesion molecule-1 by tumor necrosis factor-alpha. Arterioscler Thromb Vasc Biol. 21:917–922. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Li L, Dong F, Guo L, Hou Y, Hu H, Yan S, Zhou X, Liao L, Allen TD, Allen TD, et al: Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction. Exp Ther Med 10: 1743-1749, 2015.
APA
Li, Y., Li, L., Dong, F., Guo, L., Hou, Y., Hu, H. ... Liu, J. (2015). Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction. Experimental and Therapeutic Medicine, 10, 1743-1749. https://doi.org/10.3892/etm.2015.2721
MLA
Li, Y., Li, L., Dong, F., Guo, L., Hou, Y., Hu, H., Yan, S., Zhou, X., Liao, L., Allen, T. D., Liu, J."Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction". Experimental and Therapeutic Medicine 10.5 (2015): 1743-1749.
Chicago
Li, Y., Li, L., Dong, F., Guo, L., Hou, Y., Hu, H., Yan, S., Zhou, X., Liao, L., Allen, T. D., Liu, J."Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1743-1749. https://doi.org/10.3892/etm.2015.2721
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Li L, Dong F, Guo L, Hou Y, Hu H, Yan S, Zhou X, Liao L, Allen TD, Allen TD, et al: Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction. Exp Ther Med 10: 1743-1749, 2015.
APA
Li, Y., Li, L., Dong, F., Guo, L., Hou, Y., Hu, H. ... Liu, J. (2015). Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction. Experimental and Therapeutic Medicine, 10, 1743-1749. https://doi.org/10.3892/etm.2015.2721
MLA
Li, Y., Li, L., Dong, F., Guo, L., Hou, Y., Hu, H., Yan, S., Zhou, X., Liao, L., Allen, T. D., Liu, J."Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction". Experimental and Therapeutic Medicine 10.5 (2015): 1743-1749.
Chicago
Li, Y., Li, L., Dong, F., Guo, L., Hou, Y., Hu, H., Yan, S., Zhou, X., Liao, L., Allen, T. D., Liu, J."Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1743-1749. https://doi.org/10.3892/etm.2015.2721
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