Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2015 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2015 Volume 10 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Associations among glycemic excursions, glycated hemoglobin and high-sensitivity C-reactive protein in patients with poorly controlled type 2 diabetes mellitus

  • Authors:
    • Chun‑Hong Shi
    • Cong Wang
    • Ran Bai
    • Xue‑Yang Zhang
    • Li‑Li Men
    • Jian‑Ling Du
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
  • Pages: 1937-1942
    |
    Published online on: September 4, 2015
       https://doi.org/10.3892/etm.2015.2730
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to explore the associations among glycemic excursions, glycated hemoglobin (HbA1c) and high-sensitivity C-reactive protein (hs-CRP) in patients with poorly controlled type 2 diabetes mellitus (T2DM) using a continuous glucose monitoring system (CGMS). Sixty‑three patients with T2DM whose HbA1c levels were >7% wore a CGMS device for 72 h. According to their HbA1c levels, patients were divided into three groups as follows: Group A (HbA1c ≤9.32%), group B (9.32%< HbA1c ≤11.76%) and group C (HbA1c >11.76%). Patients were also divided into two groups according to the mean amplitude of glycemic excursions (MAGE) as follows: Low glycemic excursion group (MAGE, <3.9 mmol/l) and high glycemic excursion group (MAGE, ≥3.9 mmol/l). Clinical data and the hs‑CRP levels in different groups were compared. No significant difference was observed in the MAGE among groups A, B and C (P>0.05). The level of hs‑CRP was significantly higher in group C compared with that in groups A and B, and in group B compared with that in group A (P<0.05). Multivariate stepwise regression analysis indicated that HbA1c correlated with hs‑CRP (P<0.05). MAGE and HbA1c were independent indices for the assessment of glycemic control. In addition, HbA1c had a considerable effect on the serum hs-CRP level.
View Figures
View References

1 

Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, Shan Z, Liu J, Tian H and Ji Q: China National Diabetes and Metabolic Disorders Study Group: Prevalence of diabetes among men and women in China. N Engl J Med. 362:1090–1101. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Xu Y, Wang L, He J, Bi Y, Li M, Wang T, Wang L, Jiang Y, Dai M, Lu J, et al: 2010 China Noncommunicable Disease Surveillance Group: Prevalence and control of diabetes in Chinese adults. JAMA. 310:948–959. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Chinese medical association diabetes society: Chinese type 2 diabetes prevention guide (2010). Zhong Guo Tang Niao Bing Za Zhi She. 20:S1–S36. 2012.(In Chinese).

4 

Lachin JM, Orchard TJ and Nathan DM: DCCT/EDIC Research Group: Update on cardiovascular outcomes at 30 years of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study. Diabetes Care. 37:39–43. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Martin CL, Albers JW and Pop-Busui R: DCCT/EDIC Research Group: Neuropathy and related findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study. Diabetes Care. 37:31–38. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Holman RR, Paul SK, Bethel MA, Matthews DR and Neil HA: 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 359:1577–1589. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P and Zinman B: Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group: Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 353:2643–2653. 2005. View Article : Google Scholar : PubMed/NCBI

8 

UK Prospective Diabetes Study (UKPDS) Group: Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 352:837–853. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Cryer PE, Axelrod L, Grossman AB, Heller SR and Montori VM: Seaquist ER and Service FJ; Endocrine Society: Evaluation and management of adult hypoglycemic disorders: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 94:709–728. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Nathan DM, McGee P, Steffes MW and Lachin JM: DCCT/EDIC Research Group: Relationship of glycated albumin to blood glucose and HbA1c values and to retinopathy, nephropathy and cardiovascular outcomes in the DCCT/EDIC study. Diabetes. 63:282–290. 2014. View Article : Google Scholar : PubMed/NCBI

11 

TODAY Study Group: Retinopathy in youth with type 2 diabetes participating in the TODAY clinical trial. Diabetes Care. 36:1772–1774. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Bai R, Li L, Yao JJ, Shi SH, Liu Y, Lu Y, Du JL and Ll CC: Damage to the cultured rat mesangial cells by constant and intermittent high glucose. Zhonghua Nei Fen Mi Dai Xie Za Zhi. 26:1063–1066. 2010.(In Chinese).

13 

Di Flaviani A, Picconi F, Di Stefano P, Giordani I, Malandrucco I, Maggio P, Palazzo P, Sgreccia F, Peraldo C, Farina F, et al: Impact of glycemic and blood pressure variability on surrogate measures of cardiovascular outcomes in type 2 diabetic patients. Diabetes Care. 34:1605–1609. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Su G, Mi S, Tao H, Li Z, Yang H, Zheng H, Zhou Y and Ma C: Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes. Cardiovasc Diabetol. 10:192011. View Article : Google Scholar : PubMed/NCBI

15 

Mo Y, Zhou J, Li M, Wang Y, Bao Y, Ma X, Li D, Lu W, Hu C, Li M and Jia W: Glycemic variability is associated with subclinical atherosclerosis in Chinese type 2 diabetic patients. Cardiovasc Diabetol. 12:152013. View Article : Google Scholar : PubMed/NCBI

16 

Grossmann V, Schmitt VH, Zeller T, Panova-Noeva M, Schulz A, Laubert-Reh D, Juenger C, Schnabel RB, Abt TG, Laskowski R, et al: Profile of the immune and inflammatory response in individuals with prediabetes and type 2 diabetes. Diabetes Care. 38:1356–1364. 2015. View Article : Google Scholar : PubMed/NCBI

17 

de Vries J, Thijssen WA, Snels SE, Menovsky T, Peer NG and Lamers KJ: Intraoperative values of 100 protein, myelin basle protein, laetate and albumin in the CSF and serum of neuroeurgical patients. J Neurol Neurosurg Psychiatry. 71:671–674. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Misra DP, Das S and Sahu PK: Prevalence of inflammatory markers (high-sensitivity C-reactive protein, nuclear factor-κB and adiponectin) in Indian patients with type 2 diabetes mellitus with and without macrovascular complications. Metab Syndr Relat Disord. 10:209–213. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Asegaonkar SB, Marathe A, Tekade ML, Cherekar L, Bavikar J, Bardapurkar J and Ajay R: High-sensitivity C-reactive protein: A novel cardiovascular risk predictor in type 2 diabetics with normal lipid profile. J Diabetes Complications. 25:368–370. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Chinese Diabetes Society: China glucose monitoring clinical application guide (2011 edition). Zhong Guo Tang Niao Bing Za Zhi She. 91:656–664. 2011.(In Chinese).

21 

Meng J, Ge J, Yu C, Xu L and Gu Q: The analysis of dynamic glucose characteristics in type 2 diabetic patients with different concentration of HbA1c. Zhongguo Tang Niao Bing Za Zhi. 19:816–818. 2011.(In Chinese).

22 

Sarinnapakorn V and Wanicagool W: Association between hs-CRP and HbA1c in overweight type 2 diabetic female patients. J Med Assoc Thai. 96(Suppl 3): S54–S58. 2013.PubMed/NCBI

23 

Kilpatrick ES, Rigby AS and Atkin SL: Effect of glucose variability on the long-term risk of microvascular complications in type 1 diabetes. Diabetes Care. 32:1901–1903. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Sakurai M, Saitoh S, Miura K, Nakagawa H, Ohnishi H, Akasaka H, Kadota A, Kita Y, Hayakawa T, Ohkubo T, et al: HbA1c and the risks for all-cause and cardiovascular mortality in the general Japanese population: NIPPON DATA90. Diabetes Care. 36:3759–3765. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Sartore G, Chilelli NC, Burlina S and Lapolla A: Association between glucose variability as assessed by continuous glucose monitoring (CGM) and diabetic retinopathy in type 1 and type 2 diabetes. Acta Diabetol. 50:437–442. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol JP and Colette C: Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 295:1681–1687. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Chang CM, Hsieh CJ, Huang JC and Huang IC: Acute and chronic fluctuations in blood glucose levels can increase oxidative stress in type 2 diabetes mellitus. Acta Diabetol. 49(Suppl 1): S171–S177. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Zhang X, Xu X, Jiao X, Wu J, Zhou S and Lv X: The effects of glucose fluctuation on the severity of coronary artery disease in type 2 diabetes mellitus. J Diabetes Res. 2013:5769162013. View Article : Google Scholar : PubMed/NCBI

29 

Rizzo MR, Barbieri M, Marfella R and Paolisso G: Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: Role of dipeptidyl peptidase-IV inhibition. Diabetes Care. 35:2076–2082. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Schnell O, Amann-Zalan I, Jelsovsky Z, Moritz A, Bermejo JL, Parkin CG, Schweitzer MA, Fisher L and Polonsky WH: Changes in A1C levels are significantly associated with changes in levels of the cardiovascular risk biomarker hs-CRP: Results from the Step study. Diabetes Care. 36:2084–2089. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Yang Y, Du JL, Zhang XJ, Bai R, Ba Y, Xing Q, Sun LP, Sun GH and Li CC: Association between serum amyloid A and intima-media thickness of common carotid artery in patients with type 2 diabetes. Zhonghua Nei Fen Mi Dai Xie Za Zhi. 24:188–189. 2008.(In Chinese).

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shi CH, Wang C, Bai R, Zhang XY, Men LL and Du JL: Associations among glycemic excursions, glycated hemoglobin and high-sensitivity C-reactive protein in patients with poorly controlled type 2 diabetes mellitus. Exp Ther Med 10: 1937-1942, 2015.
APA
Shi, C., Wang, C., Bai, R., Zhang, X., Men, L., & Du, J. (2015). Associations among glycemic excursions, glycated hemoglobin and high-sensitivity C-reactive protein in patients with poorly controlled type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 10, 1937-1942. https://doi.org/10.3892/etm.2015.2730
MLA
Shi, C., Wang, C., Bai, R., Zhang, X., Men, L., Du, J."Associations among glycemic excursions, glycated hemoglobin and high-sensitivity C-reactive protein in patients with poorly controlled type 2 diabetes mellitus". Experimental and Therapeutic Medicine 10.5 (2015): 1937-1942.
Chicago
Shi, C., Wang, C., Bai, R., Zhang, X., Men, L., Du, J."Associations among glycemic excursions, glycated hemoglobin and high-sensitivity C-reactive protein in patients with poorly controlled type 2 diabetes mellitus". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1937-1942. https://doi.org/10.3892/etm.2015.2730
Copy and paste a formatted citation
x
Spandidos Publications style
Shi CH, Wang C, Bai R, Zhang XY, Men LL and Du JL: Associations among glycemic excursions, glycated hemoglobin and high-sensitivity C-reactive protein in patients with poorly controlled type 2 diabetes mellitus. Exp Ther Med 10: 1937-1942, 2015.
APA
Shi, C., Wang, C., Bai, R., Zhang, X., Men, L., & Du, J. (2015). Associations among glycemic excursions, glycated hemoglobin and high-sensitivity C-reactive protein in patients with poorly controlled type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 10, 1937-1942. https://doi.org/10.3892/etm.2015.2730
MLA
Shi, C., Wang, C., Bai, R., Zhang, X., Men, L., Du, J."Associations among glycemic excursions, glycated hemoglobin and high-sensitivity C-reactive protein in patients with poorly controlled type 2 diabetes mellitus". Experimental and Therapeutic Medicine 10.5 (2015): 1937-1942.
Chicago
Shi, C., Wang, C., Bai, R., Zhang, X., Men, L., Du, J."Associations among glycemic excursions, glycated hemoglobin and high-sensitivity C-reactive protein in patients with poorly controlled type 2 diabetes mellitus". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1937-1942. https://doi.org/10.3892/etm.2015.2730
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team